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    Polrmt RNA polymerase mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299604, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Polrmtprovided by RGD
    Official Full Name
    RNA polymerase mitochondrialprovided by RGD
    Primary source
    RGD:1304599
    See related
    EnsemblRapid:ENSRNOG00000024879 AllianceGenome:RGD:1304599
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 3'-5'-RNA exonuclease activity; DNA primase activity; and mitochondrial promoter sequence-specific DNA binding activity. Predicted to be involved in transcription initiation at mitochondrial promoter. Predicted to be located in mitochondrial nucleoid. Predicted to be part of mitochondrial DNA-directed RNA polymerase complex. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 55. Orthologous to human POLRMT (RNA polymerase mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 70.0), Heart (RPKM 69.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Polrmt in Genome Data Viewer
    Location:
    7q11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10610149..10620411)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9959532..9969791)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12840907..12851153)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 126 Neighboring gene fibroblast growth factor 22 Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Neighboring gene uncharacterized LOC134479816 Neighboring gene basigin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression. Wang Z, et al. J Biol Chem, 2007 Apr 27. PMID 17337445, Free PMC Article
    2. TEFM (c17orf42) is necessary for transcription of human mtDNA. Minczuk M, et al. Nucleic Acids Res, 2011 May. PMID 21278163, Free PMC Article
    3. Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy. Celestini V, et al. Cell Death Dis, 2018 Feb 14. PMID 29445193, Free PMC Article
    4. A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Peserico A, et al. Cell Mol Life Sci, 2013 Jun. PMID 23283301, Free PMC Article
    5. The layered structure of human mitochondrial DNA nucleoids. Bogenhagen DF, et al. J Biol Chem, 2008 Feb 8. PMID 18063578

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA primase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mitochondrial promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication, synthesis of primer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at mitochondrial promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial DNA-directed RNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase, mitochondrial
    Names
    polymerase (RNA) mitochondrial (DNA directed)
    NP_001100236.1
    XP_006240921.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106766.1 → NP_001100236.1  DNA-directed RNA polymerase, mitochondrial

      See identical proteins and their annotated locations for NP_001100236.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474029
      UniProtKB/TrEMBL
      A6K8X9, D3ZYB6
      Related
      ENSRNOP00000032448.7, ENSRNOT00000039232.7
      Conserved Domains (4) summary
      TIGR02223
      Location:22 → 164
      ftsN; cell division protein FtsN
      sd00004
      Location:198 → 225
      PPR; PPR repeat [structural motif]
      pfam00940
      Location:800 → 1202
      RNA_pol; DNA-dependent RNA polymerase
      pfam14700
      Location:390 → 672
      RPOL_N; DNA-directed RNA polymerase N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10610149..10620411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240859.5 → XP_006240921.1  DNA-directed RNA polymerase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      D3ZYB6
      Conserved Domains (4) summary
      TIGR02223
      Location:22 → 164
      ftsN; cell division protein FtsN
      sd00004
      Location:198 → 225
      PPR; PPR repeat [structural motif]
      pfam00940
      Location:801 → 1203
      RNA_pol; DNA-dependent RNA polymerase
      pfam14700
      Location:391 → 673
      RPOL_N; DNA-directed RNA polymerase N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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