IPL1 aurora kinase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: IPL1
Official Full Name: aurora kinase
Primary source: SGD:S000006130
Locus tag: YPL209C
See related: AllianceGenome:SGD:S000006130; FungiDB:YPL209C; VEuPathDB:YPL209C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PAC15
Summary: Enables protein kinase activity. Involved in several processes, including mitotic spindle disassembly; nuclear chromosome segregation; and regulation of cell cycle process. Acts upstream of or within meiotic spindle checkpoint signaling. Located in kinetochore; kinetochore microtubule; and spindle midzone. Part of chromosome passenger complex. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; spermatogenic failure 5; and uterine cancer. Orthologous to several human genes including AURKA (aurora kinase A) and AURKC (aurora kinase C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See IPL1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (156490..157593, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Low tension recruits the yeast Aurora B protein Ipl1 to centromeres in metaphase.
Title: Low tension recruits the yeast Aurora B protein Ipl1 to centromeres in metaphase.
Structure of the Ndc80 complex and its interactions at the yeast kinetochore-microtubule interface.
Title: Structure of the Ndc80 complex and its interactions at the yeast kinetochore-microtubule interface.
Killing two birds with one stone: how budding yeast Mps1 controls chromosome segregation and spindle assembly checkpoint through phosphorylation of a single kinetochore protein.
Title: Killing two birds with one stone: how budding yeast Mps1 controls chromosome segregation and spindle assembly checkpoint through phosphorylation of a single kinetochore protein.
These results give important insight into how Aurora B disrupts kinetochore-microtubule interaction in a tension-dependent manner to promote chromosome bi-orientation.
Title: Aurora B-INCENP Localization at Centromeres/Inner Kinetochores Is Required for Chromosome Bi-orientation in Budding Yeast.
While ubiquitylation likely regulates Ipl1 protein stability via the canonical proteasomal degradation pathway, a non-canonical ubiquitin-dependent pathway maintains normal Glc7 localization and activity.
Title: New ubiquitin-dependent mechanisms regulating the Aurora B-protein phosphatase 1 balance in Saccharomyces cerevisiae.
The authors show that the Ndc80 complex can simultaneously bind and bridge across two Dam1 complex rings through a tripartite interaction, each component of which is regulated by Aurora B kinase.
Title: The Ndc80 complex bridges two Dam1 complex rings.
Decatenation and condensation defects lead to spindle stabilization during cytokinesis, allowing bridge detection by Aurora B.
Title: The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress.
Shedding is regulated by the conserved protein kinase Ipl1/Aurora-B and promotes the subsequent assembly of a kinetochore.
Title: Ipl1/Aurora-B is necessary for kinetochore restructuring in meiosis I in Saccharomyces cerevisiae.
increase in Aurora B activity causes premature collapse of the mitotic spindle by promoting instability of the spindle midzone.
Title: Increased Aurora B activity causes continuous disruption of kinetochore-microtubule attachments and spindle instability.
Ipl1-dependent phosphorylation of Sli15 therefore inhibits its association with microtubules both in vivo and in vitro and may negatively regulate the tension checkpoint mechanism.
Title: Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in attachment of spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homologous chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic spindle checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic DNA integrity checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic spindle disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein import into nucleus during spindle assembly checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle spindle assembly checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromosome passenger complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aurora kinase

NP_015115.1

EC 2.7.11.1

Aurora kinase of the chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in MI, and kinetochore release from SPB clusters during meiotic exit; maintains meiotic spindle checkpoint delay in a mek1 null; maintains condensed chromosomes in anaphase; required for SPB cohesion and preventing multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; inhibits Pse1p upon SAC arrest

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

156490..157593 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184023.1 → NP_015115.1 TPA: aurora kinase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015115.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3G1, P38991

UniProtKB/TrEMBL

A6ZW46, B3LKM1, B5VSX1, C7GN36, C8ZIH0, N1NVN3

Conserved Domains (1) summary

cd14007
Location:118 → 356

STKc_Aurora; Catalytic domain of the Serine/Threonine kinase, Aurora kinase