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    ATG38 Atg38p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850908, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ATG38
    Official Full Name
    Atg38p
    Primary source
    SGD:S000004201
    Locus tag
    YLR211C
    See related
    AllianceGenome:SGD:S000004201; FungiDB:YLR211C; VEuPathDB:YLR211C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables structural molecule activity. Involved in macroautophagy. Located in phagophore assembly site and vacuolar membrane. Part of phosphatidylinositol 3-kinase complex, class III, type I. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ATG38 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    2
    Sequence:
    Chromosome: XII; NC_001144.5 (563792..564531, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene purine-nucleoside phosphorylase Neighboring gene B-type cyclin CLB4 Neighboring gene gamma-tubulin Neighboring gene putative glycosylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. Araki Y, et al. J Cell Biol, 2013 Oct 28. PMID 24165940, Free PMC Article
    2. Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex. Ohashi Y, et al. Autophagy, 2016 Nov. PMID 27630019, Free PMC Article
    3. The Atg1 complex, Atg9, and Vac8 recruit PI3K complex I to the pre-autophagosomal structure. Hitomi K, et al. J Cell Biol, 2023 Aug 7. PMID 37436710, Free PMC Article
    4. Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation. Schreiber A, et al. Mol Cell, 2021 Dec 16. PMID 34798055, Free PMC Article
    5. DeepPhagy: a deep learning framework for quantitatively measuring autophagy activity in Saccharomyces cerevisiae. Zhang Y, et al. Autophagy, 2020 Apr. PMID 31204567, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural molecule activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III, type I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Atg38p
    NP_013312.2
    • Homodimeric subunit of autophagy-specific PtdIns-3-kinase complex I; required for the integrity of the active PtdIns-3-kinase complex I by maintaining an association between Vps15p-Vps34p and Atg14p-Vps30p subcomplexes; localizes to the pre-autophagosomal structure (PAS) in an Atg14p-dependent manner; ATG38 is non-essential but is required for macroautophagy

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      563792..564531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182098.1 → NP_013312.2  TPA: Atg38p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013312.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYL2, Q05789
      UniProtKB/TrEMBL
      A7A199, B3RHA0, C7GIU0, C8ZDH5, G2WJ41, N1NYE2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05789.2

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