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    ARC15 Arc15p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854748, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ARC15
    Official Full Name
    Arc15p
    Primary source
    SGD:S000001324
    Locus tag
    YIL062C
    See related
    AllianceGenome:SGD:S000001324; FungiDB:YIL062C; VEuPathDB:YIL062C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity and protein-macromolecule adaptor activity. Involved in actin cortical patch organization and mitochondrion inheritance. Part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including ARPC5L (actin related protein 2/3 complex subunit 5 like). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ARC15 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (243998..244462, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Efm4p Neighboring gene Yrb2p Neighboring gene U1 snRNP complex subunit SNP1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Affinity filtration coupled with capillary-based affinity purification for the isolation of protein complexes. Qureshi MS, et al. Anal Biochem, 2013 Aug 1. PMID 23583819
    2. Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions. Egile C, et al. PLoS Biol, 2005 Nov. PMID 16262445, Free PMC Article
    3. Cofilin, but not profilin, is required for myosin-I-induced actin polymerization and the endocytic uptake in yeast. Idrissi FZ, et al. Mol Biol Cell, 2002 Nov. PMID 12429847, Free PMC Article
    4. Purification of Arp2/3 complex from Saccharomyces cerevisiae. Doolittle LK, et al. Methods Mol Biol, 2013. PMID 23868593, Free PMC Article
    5. A pathway for association of receptors, adaptors, and actin during endocytic internalization. Kaksonen M, et al. Cell, 2003 Nov 14. PMID 14622601

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cortical patch organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Arp2/3 protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Arp2/3 protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Arc15p
    NP_012202.1
    • Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      243998..244462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179412.1 → NP_012202.1  TPA: Arc15p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012202.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVM2, P40518
      UniProtKB/TrEMBL
      A6ZVL1, B3LTR5, B5VKP0, C7GVY6, C8ZAI6, G2WG86, N1P9C9
      Conserved Domains (1) summary
      pfam04699
      Location:4 → 152
      P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40518.1

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