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    RBFOX1 RNA binding fox-1 homolog 1 [ Homo sapiens (human) ]

    Gene ID: 54715, updated on 11-Apr-2024

    Summary

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    Official Symbol
    RBFOX1provided by HGNC
    Official Full Name
    RNA binding fox-1 homolog 1provided by HGNC
    Primary source
    HGNC:HGNC:18222
    See related
    Ensembl:ENSG00000078328 MIM:605104; AllianceGenome:HGNC:18222
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    2BP1; FOX1; A2BP1; FOX-1; HRNBP1
    Summary
    The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
    Expression
    Biased expression in brain (RPKM 11.3) and heart (RPKM 2.5) See more
    Orthologs
    mouse all
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    Try the new Transcript table

    Genomic context

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    Location:
    16p13.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (5239721..7713340)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (5269380..7744948)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (6069025..7763342)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371067 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:5262989-5263709 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:5286836-5288035 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5298918-5299751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:5300840-5301508 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5302176-5302843 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5302844-5303510 Neighboring gene 40S ribosomal protein S24-like Neighboring gene long intergenic non-protein coding RNA 2164 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:5371684-5372883 Neighboring gene VPS51 pseudogene 1 Neighboring gene RPS3A pseudogene 48 Neighboring gene small nuclear ribonucleoprotein polypeptide C pseudogene 20 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:5496759-5497327 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5500131-5500853 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5500854-5501575 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:5609581-5610780 Neighboring gene nucleophosmin 1 pseudogene 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:5692155-5693354 Neighboring gene MPRA-validated peak2482 silencer Neighboring gene MPRA-validated peak2483 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:5755936-5757135 Neighboring gene long intergenic non-protein coding RNA 1570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:5800209-5800710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:5800711-5801210 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:5804472-5805458 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:5845663-5846190 Neighboring gene microRNA 8065 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:5920971-5921940 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5975719-5976364 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:6052649-6053848 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:6072816-6074015 Neighboring gene meiotic recombination hotspot CG Neighboring gene NANOG hESC enhancer GRCh37_chr16:6174118-6174635 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6226269-6227053 Neighboring gene NANOG hESC enhancer GRCh37_chr16:6348193-6348738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6372883-6373383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6372382-6372882 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6391810-6392696 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6392697-6393582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6532635-6533560 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancers GRCh37_chr16:6607366-6608270 and GRCh37_chr16:6608271-6609174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6623253-6623754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6623755-6624254 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6910998-6911814 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6913069-6913652 Neighboring gene RNA, U7 small nuclear 99 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6963086-6963586 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:6975920-6976594 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:6976595-6977269 Neighboring gene RNA, U6 small nuclear 457, pseudogene Neighboring gene MPRA-validated peak2485 silencer Neighboring gene uncharacterized LOC105371068 Neighboring gene RNA, U6 small nuclear 328, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:7231546-7232745 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:7234679-7235878 Neighboring gene Sharpr-MPRA regulatory region 8564 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_44361 Neighboring gene MPRA-validated peak2487 silencer Neighboring gene ribosomal protein S26 pseudogene 51 Neighboring gene uncharacterized LOC124903640 Neighboring gene NANOG hESC enhancer GRCh37_chr16:7481632-7482288 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:7629446-7630645 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:7701751-7702302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:7703336-7703942 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:7758954-7760153 Neighboring gene uncharacterized LOC124900381 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:7814521-7815243 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:7815244-7815965 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:7819497-7820696 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:7917473-7918672 Neighboring gene uncharacterized LOC105371069

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits. O'Leary A, et al. Mol Psychiatry, 2022 Nov. PMID 35948661, Free PMC Article
    2. Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease. Raghavan NS, et al. JAMA Neurol, 2020 Oct 1. PMID 32568366, Free PMC Article
    3. Polymorphisms of rs4787050 and rs8045980 are associated with lung cancer risk in northeast Chinese female nonsmokers. Li X, et al. Biomark Med, 2019 Sep. PMID 31512508
    4. RNA-binding protein (RBFOX1) inherited polymorphism rs8051518 is not associated with splice factor mutations in myelodysplastic syndromes and myeloproliferative neoplasms. Faisal M, et al. Ann Hematol, 2019 May. PMID 30159600
    5. Structural study of the Fox-1 RRM protein hydration reveals a role for key water molecules in RRM-RNA recognition. Krepl M, et al. Nucleic Acids Res, 2017 Jul 27. PMID 28505313, Free PMC Article

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Patient Brain Organoids Identify a Link between the 16p11.2 Copy Number Variant and the RBFOX1 Gene.
      Title: Patient Brain Organoids Identify a Link between the 16p11.2 Copy Number Variant and the RBFOX1 Gene.
    2. Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits.
      Title: Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits.
    3. Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1.
      Title: Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1.
    4. Differential Clinical Features in Colombian Patients With Rolandic Epilepsy and Suggestion of Unlikely Association With GRIN2A, RBFOX1, or RBFOX3 Gene Variants.
      Title: Differential Clinical Features in Colombian Patients With Rolandic Epilepsy and Suggestion of Unlikely Association With GRIN2A, RBFOX1, or RBFOX3 Gene Variants.
    5. RNA-binding proteins in neurological development and disease.
      Title: RNA-binding proteins in neurological development and disease.
    6. Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease.
      Title: Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease.
    7. Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.
      Title: Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.
    8. From Rare Copy Number Variants to Biological Processes in ADHD.
      Title: From Rare Copy Number Variants to Biological Processes in ADHD.
    9. The SNPs rs4787050 and rs8045980 showed a significant association with susceptibility to lung cancer. Moreover, cooking oil fume exposure was found to increase the risk of lung cancer.
      Title: Polymorphisms of rs4787050 and rs8045980 are associated with lung cancer risk in northeast Chinese female nonsmokers.
    10. this study shows that RBFOX1 is a susceptibility gene for an outbreak of hydrolyzed wheat allergy in Japan
      Title: HLA-DQ and RBFOX1 as susceptibility genes for an outbreak of hydrolyzed wheat allergy.
    Submit: New GeneRIF Correction See all GeneRIFs (56)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of sleep habits and insomnia.
    EBI GWAS Catalog
    A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
    EBI GWAS Catalog
    Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
    EBI GWAS Catalog
    Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.
    EBI GWAS Catalog
    Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.
    EBI GWAS Catalog
    Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study and meta-analysis of intraocular pressure.
    EBI GWAS Catalog
    Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
    EBI GWAS Catalog
    Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.
    EBI GWAS Catalog
    Genome-wide association study of chronic periodontitis in a general German population.
    EBI GWAS Catalog
    Genome-Wide Association Study of Primary Dentition Pit-and-Fissure and Smooth Surface Caries.
    EBI GWAS Catalog
    Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
    EBI GWAS Catalog
    Genome-wide meta-analysis for severe diabetic retinopathy.
    EBI GWAS Catalog
    Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 Loci.
    EBI GWAS Catalog
    Genomewide association study of movement-related adverse antipsychotic effects.
    EBI GWAS Catalog
    Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
    EBI GWAS Catalog
    Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA binding protein fox-1 homolog 1
    Names
    RNA binding protein, fox-1 homolog 1
    ataxin 2-binding protein 1
    fox-1 homolog A
    fox-1-like RNA-binding protein 1
    hexaribonucleotide-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011881.2 RefSeqGene

      Range
      784273..2478589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142333.2 → NP_001135805.1  RNA binding protein fox-1 homolog 1 isoform 5

      See identical proteins and their annotated locations for NP_001135805.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus and other internal differences compared to isoform 1.
      Source sequence(s)
      AB208826, AC005774, AC009135, AF448859
      Consensus CDS
      CCDS55984.1
      UniProtKB/TrEMBL
      A0A087X2B1
      Related
      ENSP00000447753.1, ENST00000553186.5
      Conserved Domains (3) summary
      PRK03427
      Location:4 → 122
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:226 → 315
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:117 → 192
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    2. NM_001142334.2 → NP_001135806.1  RNA binding protein fox-1 homolog 1 isoform 4

      See identical proteins and their annotated locations for NP_001135806.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks an in-frame section of the 3' coding region, compared to variant 1. This results in a shorter isoform (4) with an alternate N-terminus compared to isoform 1. Variants 4 and 6 both encode isoform 4.
      Source sequence(s)
      AC005774, AF107203, AK001027
      Consensus CDS
      CCDS55983.1
      UniProtKB/Swiss-Prot
      Q7Z7I7, Q8TAE3, Q8TAF2, Q8WYB2, Q9NS20, Q9NWB1
      UniProtKB/TrEMBL
      I3L1D4
      Related
      ENSP00000447717.1, ENST00000547338.5
      Conserved Domains (3) summary
      PRK03427
      Location:4 → 122
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:253 → 342
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:117 → 192
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    3. NM_001308117.1 → NP_001295046.1  RNA binding protein fox-1 homolog 1 isoform 6

      See identical proteins and their annotated locations for NP_001295046.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the UTRs and has multiple differences in the coding region which results in the use of an alternate start codon and a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (6) has a longer N-terminus and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC005774, AC027683, AK293951
      Consensus CDS
      CCDS76818.1
      UniProtKB/TrEMBL
      B7Z1U7, I3L1D4
      Related
      ENSP00000391269.4, ENST00000422070.8
      Conserved Domains (3) summary
      PRK03427
      Location:33 → 165
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:296 → 385
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:160 → 235
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    4. NM_001364800.2 → NP_001351729.1  RNA binding protein fox-1 homolog 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152
      Consensus CDS
      CCDS92101.1
      UniProtKB/TrEMBL
      A0A6Q8PH77, F8VRS4
      Related
      ENSP00000502616.1, ENST00000675459.1
      Conserved Domains (3) summary
      PRK03427
      Location:4 → 122
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:253 → 339
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:117 → 192
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    5. NM_001411047.1 → NP_001397976.1  RNA binding protein fox-1 homolog 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152
      Consensus CDS
      CCDS92100.1
      UniProtKB/TrEMBL
      F8VZG9
      Related
      ENSP00000446842.1, ENST00000547372.5

    6. NM_001415887.1 → NP_001402816.1  RNA binding protein fox-1 homolog 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC005563, AC005774, AC007012, AC007217, AC012175, AC022206, AC023822, AC027683, AC074051, KF456152

    7. NM_001415888.1 → NP_001402817.1  RNA binding protein fox-1 homolog 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC005563, AC005774, AC007012, AC007217, AC012175, AC022206, AC023822, AC027683, AC074051, KF456152

    8. NM_001415889.1 → NP_001402818.1  RNA binding protein fox-1 homolog 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152
      Related
      ENSP00000438768.2, ENST00000535565.6

    9. NM_001415890.1 → NP_001402819.1  RNA binding protein fox-1 homolog 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152

    10. NM_001415891.1 → NP_001402820.1  RNA binding protein fox-1 homolog 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152

    11. NM_001415892.1 → NP_001402821.1  RNA binding protein fox-1 homolog 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152

    12. NM_001415893.1 → NP_001402822.1  RNA binding protein fox-1 homolog 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      Related
      ENST00000676253.1

    13. NM_001415894.1 → NP_001402823.1  RNA binding protein fox-1 homolog 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152

    14. NM_001415895.1 → NP_001402824.1  RNA binding protein fox-1 homolog 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152

    15. NM_001415896.1 → NP_001402825.1  RNA binding protein fox-1 homolog 1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      UniProtKB/TrEMBL
      X5DNY3
      Related
      ENSP00000484837.1, ENST00000620507.4

    16. NM_001415897.1 → NP_001402826.1  RNA binding protein fox-1 homolog 1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152

    17. NM_001415898.1 → NP_001402827.1  RNA binding protein fox-1 homolog 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152
      Related
      ENSP00000448496.1, ENST00000552089.5

    18. NM_001415899.1 → NP_001402828.1  RNA binding protein fox-1 homolog 1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152

    19. NM_001415900.1 → NP_001402829.1  RNA binding protein fox-1 homolog 1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152

    20. NM_001415901.1 → NP_001402830.1  RNA binding protein fox-1 homolog 1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      Related
      ENSP00000501878.1, ENST00000675562.1

    21. NM_001415902.1 → NP_001402831.1  RNA binding protein fox-1 homolog 1 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC027683, KF456152
      Related
      ENSP00000458748.2, ENST00000570626.2

    22. NM_001415903.1 → NP_001402832.1  RNA binding protein fox-1 homolog 1 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152

    23. NM_001415904.1 → NP_001402833.1  RNA binding protein fox-1 homolog 1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      UniProtKB/TrEMBL
      X5D7T5

    24. NM_001415905.1 → NP_001402834.1  RNA binding protein fox-1 homolog 1 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152

    25. NM_001415906.1 → NP_001402835.1  RNA binding protein fox-1 homolog 1 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152

    26. NM_001415907.1 → NP_001402836.1  RNA binding protein fox-1 homolog 1 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152

    27. NM_001415908.1 → NP_001402837.1  RNA binding protein fox-1 homolog 1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152

    28. NM_001415909.1 → NP_001402838.1  RNA binding protein fox-1 homolog 1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152

    29. NM_001415910.1 → NP_001402839.1  RNA binding protein fox-1 homolog 1 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152

    30. NM_001415911.1 → NP_001402840.1  RNA binding protein fox-1 homolog 1 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC027683, KF456152
      UniProtKB/TrEMBL
      A0A804HJM2
      Related
      ENSP00000507562.1, ENST00000683326.1

    31. NM_001415912.1 → NP_001402841.1  RNA binding protein fox-1 homolog 1 isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152

    32. NM_001415913.1 → NP_001402842.1  RNA binding protein fox-1 homolog 1 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152

    33. NM_001415914.1 → NP_001402843.1  RNA binding protein fox-1 homolog 1 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152

    34. NM_001415915.1 → NP_001402844.1  RNA binding protein fox-1 homolog 1 isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      UniProtKB/TrEMBL
      X5DP44

    35. NM_001415916.1 → NP_001402845.1  RNA binding protein fox-1 homolog 1 isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152

    36. NM_001415917.1 → NP_001402846.1  RNA binding protein fox-1 homolog 1 isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC027683, KF456152
      UniProtKB/TrEMBL
      A0A804HKG7
      Related
      ENSP00000507921.1, ENST00000682918.1

    37. NM_018723.4 → NP_061193.2  RNA binding protein fox-1 homolog 1 isoform 4

      See identical proteins and their annotated locations for NP_061193.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame section of the 3' coding region, compared to variant 1. This results in a shorter isoform (4) with an alternate N-terminus compared to isoform 1. Variants 4 and 6 both encode isoform 4.
      Source sequence(s)
      AB208826, AC005774, AC009135, AF107203
      Consensus CDS
      CCDS55983.1
      UniProtKB/Swiss-Prot
      Q7Z7I7, Q8TAE3, Q8TAF2, Q8WYB2, Q9NS20, Q9NWB1
      UniProtKB/TrEMBL
      I3L1D4
      Related
      ENSP00000450031.1, ENST00000550418.6
      Conserved Domains (3) summary
      PRK03427
      Location:4 → 122
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:253 → 342
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:117 → 192
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    38. NM_145891.3 → NP_665898.1  RNA binding protein fox-1 homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_665898.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as gamma, encodes isoform (1).
      Source sequence(s)
      AC005774, AF229057
      Consensus CDS
      CCDS10531.1
      UniProtKB/TrEMBL
      B7ZLH9
      Related
      ENSP00000309117.5, ENST00000311745.9
      Conserved Domains (3) summary
      TIGR01661
      Location:25 → 208
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      pfam12414
      Location:273 → 363
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:137 → 212
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    39. NM_145892.3 → NP_665899.1  RNA binding protein fox-1 homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_665899.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as alpha, lacks an in-frame segment of the 3' coding region, compared to variant 1. This results in a shorter isoform (2) that lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC005774, AF094849
      Consensus CDS
      CCDS45405.1
      UniProtKB/TrEMBL
      I3L1D4
      Related
      ENSP00000402745.2, ENST00000436368.6
      Conserved Domains (3) summary
      TIGR01661
      Location:25 → 208
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      pfam12414
      Location:273 → 363
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:137 → 212
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    40. NM_145893.3 → NP_665900.1  RNA binding protein fox-1 homolog 1 isoform 3

      See identical proteins and their annotated locations for NP_665900.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as beta, has an alternate exon in the 3' coding region, compared to variant 1. This results in a shorter isoform (3) with an alternate C-terminus, compared to isoform 1.
      Source sequence(s)
      AC005774, AF109106
      Consensus CDS
      CCDS10532.1
      UniProtKB/TrEMBL
      A0A6Q8PFM4
      Related
      ENSP00000347855.4, ENST00000355637.9
      Conserved Domains (3) summary
      TIGR01661
      Location:25 → 208
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      pfam12414
      Location:273 → 360
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:137 → 212
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      5239721..7713340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023318.3 → XP_016878807.1  RNA binding protein fox-1 homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A286YEU2
      Related
      ENSP00000493041.1, ENST00000641259.1

    2. XM_024450303.2 → XP_024306071.1  RNA binding protein fox-1 homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A286YEU2
      Conserved Domains (4) summary
      PHA03169
      Location:18 → 156
      PHA03169; hypothetical protein; Provisional
      cd12407
      Location:303 → 378
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:439 → 528
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl27169
      Location:176 → 308
      ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

    3. XM_017023320.3 → XP_016878809.1  RNA binding protein fox-1 homolog 1 isoform X3

      UniProtKB/TrEMBL
      F8VRS4
      Conserved Domains (4) summary
      PHA03193
      Location:88 → 155
      PHA03193; tegument protein VP11/12; Provisional
      COG0724
      Location:143 → 243
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:160 → 235
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:296 → 383
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    4. XM_017023321.3 → XP_016878810.1  RNA binding protein fox-1 homolog 1 isoform X4

      UniProtKB/TrEMBL
      F8VRS4
      Conserved Domains (3) summary
      PRK03427
      Location:26 → 158
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:153 → 228
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:289 → 378
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    5. XM_024450305.2 → XP_024306073.1  RNA binding protein fox-1 homolog 1 isoform X7

      UniProtKB/TrEMBL
      F8VRS4
      Conserved Domains (3) summary
      cd12407
      Location:153 → 228
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:262 → 350
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl27169
      Location:26 → 158
      ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

    6. XM_005255391.5 → XP_005255448.1  RNA binding protein fox-1 homolog 1 isoform X9

      See identical proteins and their annotated locations for XP_005255448.1

      UniProtKB/TrEMBL
      A0A6Q8PFM4
      Conserved Domains (3) summary
      PRK03427
      Location:4 → 122
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:117 → 192
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:253 → 342
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    7. XM_047434244.1 → XP_047290200.1  RNA binding protein fox-1 homolog 1 isoform X9

    8. XM_005255386.5 → XP_005255443.1  RNA binding protein fox-1 homolog 1 isoform X5

      UniProtKB/TrEMBL
      A0A6Q8PFM4
      Conserved Domains (4) summary
      PHA03193
      Location:70 → 137
      PHA03193; tegument protein VP11/12; Provisional
      COG0724
      Location:125 → 225
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:142 → 217
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:278 → 365
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    9. XM_005255387.5 → XP_005255444.1  RNA binding protein fox-1 homolog 1 isoform X6

      See identical proteins and their annotated locations for XP_005255444.1

      UniProtKB/TrEMBL
      A0A6Q8PFM4
      Conserved Domains (3) summary
      TIGR01661
      Location:25 → 208
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      pfam12414
      Location:273 → 360
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:137 → 212
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    10. XM_024450306.2 → XP_024306074.1  RNA binding protein fox-1 homolog 1 isoform X10

      UniProtKB/TrEMBL
      B7Z608
      Conserved Domains (3) summary
      PRK14971
      Location:19 → 187
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam12414
      Location:242 → 331
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl17169
      Location:137 → 176
      RRM_SF; RNA recognition motif (RRM) superfamily

    11. XM_047434249.1 → XP_047290205.1  RNA binding protein fox-1 homolog 1 isoform X11

    12. XM_047434243.1 → XP_047290199.1  RNA binding protein fox-1 homolog 1 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      5269380..7744948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380514.1 → XP_054236489.1  RNA binding protein fox-1 homolog 1 isoform X1

    2. XM_054380515.1 → XP_054236490.1  RNA binding protein fox-1 homolog 1 isoform X2

    3. XM_054380516.1 → XP_054236491.1  RNA binding protein fox-1 homolog 1 isoform X3

    4. XM_054380520.1 → XP_054236495.1  RNA binding protein fox-1 homolog 1 isoform X7

    5. XM_054380517.1 → XP_054236492.1  RNA binding protein fox-1 homolog 1 isoform X4

    6. XM_054380523.1 → XP_054236498.1  RNA binding protein fox-1 homolog 1 isoform X9

    7. XM_054380521.1 → XP_054236496.1  RNA binding protein fox-1 homolog 1 isoform X12

    8. XM_054380518.1 → XP_054236493.1  RNA binding protein fox-1 homolog 1 isoform X5

    9. XM_054380519.1 → XP_054236494.1  RNA binding protein fox-1 homolog 1 isoform X6

    10. XM_054380524.1 → XP_054236499.1  RNA binding protein fox-1 homolog 1 isoform X10

    11. XM_054380526.1 → XP_054236501.1  RNA binding protein fox-1 homolog 1 isoform X13

    12. XM_054380522.1 → XP_054236497.1  RNA binding protein fox-1 homolog 1 isoform X8

    13. XM_054380525.1 → XP_054236500.1  RNA binding protein fox-1 homolog 1 isoform X11

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NWB1.2 GenPept UniProtKB/Swiss-Prot:Q9NWB1

    Gene LinkOut

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