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    TUBGCP5 tubulin gamma complex component 5 [ Homo sapiens (human) ]

    Gene ID: 114791, updated on 3-Apr-2024

    Summary

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    Official Symbol
    TUBGCP5provided by HGNC
    Official Full Name
    tubulin gamma complex component 5provided by HGNC
    Primary source
    HGNC:HGNC:18600
    See related
    Ensembl:ENSG00000275835 MIM:608147; AllianceGenome:HGNC:18600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCP5
    Summary
    Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome and cytosol. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 5.8), brain (RPKM 3.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    15q11.2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (22983025..23039569, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (20654893..20711463, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (22833499..22890043)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr15:23086519-23086752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6260 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:23080143-23080643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9155 Neighboring gene NIPA magnesium transporter 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:23045427-23046179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9158 Neighboring gene NIPA magnesium transporter 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22999149-22999824 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:22990202-22991401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22981163-22981662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22980661-22981162 Neighboring gene cytoplasmic FMR1 interacting protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22925256-22925940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22905531-22906030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22896003-22896502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22895501-22896002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22893404-22894371 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22892435-22893403 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22859095-22860005 Neighboring gene NANOG hESC enhancer GRCh37_chr15:22803142-22803643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22798435-22798945 Neighboring gene engulfment and cell motility 2 pseudogene 1 Neighboring gene WAS/WASL-interacting protein family member 3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5. Izumi N, et al. J Biol Chem, 2008 May 9. PMID 18316369
    2. Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome. Bittel DC, et al. Pediatrics, 2006 Oct. PMID 16982806, Free PMC Article
    3. GCP5 and GCP6: two new members of the human gamma-tubulin complex. Murphy SM, et al. Mol Biol Cell, 2001 Nov. PMID 11694571, Free PMC Article
    4. Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis. Hsu HL, et al. J Cell Sci, 1996 Feb. PMID 8838651
    5. CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex. Choi YK, et al. J Cell Biol, 2010 Dec 13. PMID 21135143, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GSK-3beta regulates the localization of gamma-tubulin ring complex, including GCP5, to the spindle poles, thereby controlling the formation of proper mitotic spindles
      Title: GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5.
    2. located in the genomic domain between break points 1 and 2 on chromosome 15, of the Prader-Willi/Angelman syndromes
      Title: Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons.
    3. quantitated mRNA levels of NIPA2, NIPA2,l CYFIP1, and GCP5 in Prader-Willi syndrome and correlated levels with psychological and behavior scales
      Title: Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1899

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in equatorial microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin ring complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-tubulin complex component 5
    Names
    gamma-tubulin complex component GCP5
    tubulin gamma complex associated protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102610.2 → NP_001096080.1  gamma-tubulin complex component 5 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site at its 3' terminal exon, compared to variant 1, and encodes isoform b. Isoforms a and b are identical in length but differ in their C-termini.
      Source sequence(s)
      AB067486, AC116166, AK056416
      Consensus CDS
      CCDS73697.1
      UniProtKB/TrEMBL
      A0A0G2JQX1
      Related
      ENSP00000481853.1, ENST00000620435.4
      Conserved Domains (1) summary
      pfam04130
      Location:273 → 942
      Spc97_Spc98; Spc97 / Spc98 family

    2. NM_001354372.2 → NP_001341301.1  gamma-tubulin complex component 5 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC090764, AC116166
      UniProtKB/TrEMBL
      A0A0G2JPW5, A0A0G2JQX1, A8K1E4
      Conserved Domains (1) summary
      pfam04130
      Location:274 → 943
      Spc97_Spc98; Spc97 / Spc98 family

    3. NM_001354373.2 → NP_001341302.1  gamma-tubulin complex component 5 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC090764, AC116166
      UniProtKB/TrEMBL
      A0A0G2JPW5, A0A0G2JQX1, A8K1E4
      Related
      ENSP00000484566.1, ENST00000614508.4
      Conserved Domains (1) summary
      pfam04130
      Location:273 → 942
      Spc97_Spc98; Spc97 / Spc98 family

    4. NM_001354374.2 → NP_001341303.1  gamma-tubulin complex component 5 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC090764, AC116166
      UniProtKB/TrEMBL
      A0A0G2JPW5, A0A0G2JQX1, A8K1E4
      Conserved Domains (1) summary
      pfam04130
      Location:273 → 928
      Spc97_Spc98; Spc97 / Spc98 family

    5. NM_001354375.2 → NP_001341304.1  gamma-tubulin complex component 5 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC090764, AC116166
      UniProtKB/TrEMBL
      A0A087X1Z1
      Conserved Domains (1) summary
      pfam04130
      Location:273 → 942
      Spc97_Spc98; Spc97 / Spc98 family

    6. NM_001354376.2 → NP_001341305.1  gamma-tubulin complex component 5 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC090764, AC116166
      UniProtKB/TrEMBL
      A0A087X1Z1
      Conserved Domains (1) summary
      pfam04130
      Location:273 → 942
      Spc97_Spc98; Spc97 / Spc98 family

    7. NM_001354377.2 → NP_001341306.1  gamma-tubulin complex component 5 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate splice sites compared to variant 1, and encodes isoform h. Isoforms h and i are identical in length but differ in their C-termini.
      Source sequence(s)
      AC116166
      UniProtKB/TrEMBL
      A0A0G2JPW5, A8K1E4
      Conserved Domains (1) summary
      pfam04130
      Location:274 → 943
      Spc97_Spc98; Spc97 / Spc98 family

    8. NM_001354378.2 → NP_001341307.1  gamma-tubulin complex component 5 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) uses an alternate splice sites compared to variant 1, and encodes isoform i. Isoforms h and i are identical in length but differ in their C-termini.
      Source sequence(s)
      AC116166
      UniProtKB/TrEMBL
      A0A0G2JQX1
      Conserved Domains (1) summary
      pfam04130
      Location:274 → 943
      Spc97_Spc98; Spc97 / Spc98 family

    9. NM_052903.6 → NP_443135.3  gamma-tubulin complex component 5 isoform a

      See identical proteins and their annotated locations for NP_443135.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Isoforms a and b are identical in length but differ in their C-termini.
      Source sequence(s)
      AB067486, BC071560
      Consensus CDS
      CCDS73698.1
      UniProtKB/Swiss-Prot
      E9PB12, Q6IQ52, Q96PY8, Q96RT8
      UniProtKB/TrEMBL
      A0A0G2JPW5, A8K1E4
      Related
      ENSP00000480316.1, ENST00000615383.5
      Conserved Domains (2) summary
      pfam04130
      Location:716 → 1017
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:271 → 577
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    RNA

    1. NR_148875.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090764, AC116166

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      22983025..23039569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432130.1 → XP_047288086.1  gamma-tubulin complex component 5 isoform X3

    2. XM_017021895.2 → XP_016877384.1  gamma-tubulin complex component 5 isoform X4

      UniProtKB/TrEMBL
      A8K1E4

    3. XM_017021894.2 → XP_016877383.1  gamma-tubulin complex component 5 isoform X3

      UniProtKB/TrEMBL
      A8K1E4

    4. XM_017021896.2 → XP_016877385.1  gamma-tubulin complex component 5 isoform X6

    5. XM_017021901.2 → XP_016877390.1  gamma-tubulin complex component 5 isoform X7

    6. XM_011543870.3 → XP_011542172.1  gamma-tubulin complex component 5 isoform X2

      UniProtKB/TrEMBL
      A0A087X1Z1
      Conserved Domains (1) summary
      pfam04130
      Location:274 → 943
      Spc97_Spc98; Spc97 / Spc98 family

    7. XM_011543868.3 → XP_011542170.1  gamma-tubulin complex component 5 isoform X1

      UniProtKB/TrEMBL
      A0A087X1Z1
      Conserved Domains (1) summary
      pfam04130
      Location:274 → 943
      Spc97_Spc98; Spc97 / Spc98 family

    8. XM_047432131.1 → XP_047288087.1  gamma-tubulin complex component 5 isoform X5

    RNA

    1. XR_007064420.1 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160017.1 Reference GRCh38.p14 PATCHES

      Range
      3877112..3933660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332577.1 → XP_054188552.1  gamma-tubulin complex component 5 isoform X3

    2. XM_054332579.1 → XP_054188554.1  gamma-tubulin complex component 5 isoform X4

    3. XM_054332578.1 → XP_054188553.1  gamma-tubulin complex component 5 isoform X3

    4. XM_054332581.1 → XP_054188556.1  gamma-tubulin complex component 5 isoform X6

    5. XM_054332582.1 → XP_054188557.1  gamma-tubulin complex component 5 isoform X7

    6. XM_054332576.1 → XP_054188551.1  gamma-tubulin complex component 5 isoform X2

    7. XM_054332575.1 → XP_054188550.1  gamma-tubulin complex component 5 isoform X1

    8. XM_054332580.1 → XP_054188555.1  gamma-tubulin complex component 5 isoform X5

    RNA

    1. XR_008485783.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187603.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      79960..136590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329039.1 → XP_054185014.1  gamma-tubulin complex component 5 isoform X7

    2. XM_054329038.1 → XP_054185013.1  gamma-tubulin complex component 5 isoform X6

    3. XM_054329037.1 → XP_054185012.1  gamma-tubulin complex component 5 isoform X3

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187659.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      1543..4302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      20654893..20711463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377247.1 → XP_054233222.1  gamma-tubulin complex component 5 isoform X3

    2. XM_054377249.1 → XP_054233224.1  gamma-tubulin complex component 5 isoform X4

    3. XM_054377248.1 → XP_054233223.1  gamma-tubulin complex component 5 isoform X3

    4. XM_054377251.1 → XP_054233226.1  gamma-tubulin complex component 5 isoform X6

    5. XM_054377252.1 → XP_054233227.1  gamma-tubulin complex component 5 isoform X7

    6. XM_054377246.1 → XP_054233221.1  gamma-tubulin complex component 5 isoform X2

    7. XM_054377245.1 → XP_054233220.1  gamma-tubulin complex component 5 isoform X1

    8. XM_054377250.1 → XP_054233225.1  gamma-tubulin complex component 5 isoform X5

    RNA

    1. XR_008488915.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96RT8.1 GenPept UniProtKB/Swiss-Prot:Q96RT8

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