CNTN4 contactin 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CNTN4provided by HGNC
Official Full Name: contactin 4provided by HGNC
Primary source: HGNC:HGNC:2174
See related: Ensembl:ENSG00000144619 MIM:607280; AllianceGenome:HGNC:2174
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AXCAM; BIG-2
Summary: This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Expression: Broad expression in endometrium (RPKM 2.7), thyroid (RPKM 2.4) and 21 other tissues See more
Orthologs: all
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Genomic context

Location:: 3p26.3-p26.2

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (2098866..3057959)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (2092772..3052283)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (2140550..3099643)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PPARGC1B and CNTN4 genotypes are associated with elevated thromboxane A2 formation and with an excess of cardiovascular events. Aspirin appears to blunt these associations.
Title: Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A(2) formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).
High CNTN4 expression is associated with Pheochromocytomas and Paragangliomas.
Title: Expression of Contactin 4 Is Associated With Malignant Behavior in Pheochromocytomas and Paragangliomas.
Association between contactin 4 (CNTN4) and antisaccade and P300 in schizophrenia.
Title: Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci.
SNPs within the CNTN4 gene are associated with increased risk of oral cancer.
Title: Single nucleotide polymorphisms in an Indian cohort and association of CNTN4, MMP2 and SNTB1 variants with oral cancer.
SNPs in ITPR1 and CNTN4 are involved in the regulation of serum uric acid concentrations in Mexican Americans
Title: GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans.
By combining methylation and SNP data, CNTN4 was identified as a risk factor for regular alcohol use.
Title: Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use.
data reveal critical and novel roles for CNTN4/amyloid precursor protein in promoting target-specific axon arborization
Title: Contactin-4 mediates axon-target specificity and functional development of the accessory optic system.
We identified CNTN4 as a novel candidate gene for POAG.
Title: Gene-rich large deletions are overrepresented in POAG patients of Indian and Caucasian origins.
these results suggest that rare copy number variations in CNTN4 may also influence autism susceptibility in Asian populations.
Title: Disruption of Contactin 4 in two subjects with autism in Chinese population.
Using array comparative genome hybridization (CGH), we identified a maternally inherited approximately 535 kb deletion at 3p26.3 encompassing the 5' end of the contactin 4 gene (CNTN4) in a patient with autism.
Title: Contactin 4 as an autism susceptibility locus.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2022-06-14) ClinGen Genome Curation Page Haploinsufficency No evidence available (Last evaluated 2022-06-14) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of acenocoumarol maintenance dosage. EBI GWAS Catalog EBI GWAS CatalogPubMed
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. EBI GWAS Catalog EBI GWAS CatalogPubMed
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of intelligence: additive effects of novel brain expressed genes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-Wide Association Study of Primary Dentition Pit-and-Fissure and Smooth Surface Caries. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. EBI GWAS Catalog EBI GWAS CatalogPubMed
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH11898 (e-PCR)
- UniSTS:6144

RH92569 (e-PCR)
- UniSTS:92965

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-144696 (e-PCR)
- UniSTS:172361

D3S3972 (e-PCR)
- UniSTS:7498

RH122760 (e-PCR)
- UniSTS:134989

RH123897 (e-PCR)
- UniSTS:136272

G59744 (e-PCR)
- UniSTS:137040

G19165 (e-PCR)
- UniSTS:1363

D3S3630 (e-PCR), detects polymorphism
- UniSTS:4724

D3S4051 (e-PCR)
- UniSTS:5245

D5S1982 (e-PCR), detects polymorphism
- UniSTS:11651

SHGC-141955 (e-PCR)
- UniSTS:171156

SHGC-146949 (e-PCR)
- UniSTS:175523

D3S3525 (e-PCR), detects polymorphism
- UniSTS:46512

RH121052 (e-PCR)
- UniSTS:132273

SHGC-149135 (e-PCR)
- UniSTS:176820

SHGC-56908 (e-PCR)
- UniSTS:47034

SHGC-142879 (e-PCR)
- UniSTS:171719

RH118539 (e-PCR)
- UniSTS:137936

D3S2358 (e-PCR)
- UniSTS:13281

RH68658 (e-PCR)
- UniSTS:1261

SHGC-79997 (e-PCR)
- UniSTS:101621

SHGC-147539 (e-PCR)
- UniSTS:175865

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	TAS Traceable Author Statement more info	PubMed
involved_in axonal fasciculation	TAS Traceable Author Statement more info	PubMed
involved_in axonogenesis	TAS Traceable Author Statement more info	PubMed
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic plasticity	TAS Traceable Author Statement more info	PubMed
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: contactin-4

Names: axonal-associated cell adhesion molecule; brain-derived immunoglobulin superfamily protein 2; neural cell adhesion protein BIG-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012827.2 RefSeqGene

Range

3304..962397

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001206955.2 → NP_001193884.1 contactin-4 isoform a precursor

See identical proteins and their annotated locations for NP_001193884.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4 and 6 encode the same isoform (a).

Source sequence(s)

AC022002, AC024057, AF549455, R42166

Consensus CDS

CCDS43041.1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35

Related

ENSP00000380602.1, ENST00000397461.5

Conserved Domains (4) summary

cd05853
Location:513 → 597

Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4

cd00063
Location:597 → 690

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd04969
Location:422 → 494

Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin

cl11960
Location:225 → 313

Ig; Immunoglobulin domain
NM_001206956.2 → NP_001193885.1 contactin-4 isoform d

See identical proteins and their annotated locations for NP_001193885.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream in-frame start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AC022002, BC026119, DB457029, R42166

UniProtKB/TrEMBL

B3KQ34

Conserved Domains (2) summary

cd00063
Location:268 → 361

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:185 → 268

Ig; Immunoglobulin domain
NM_001350095.2 → NP_001337024.1 contactin-4 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 4 and 6 encode the same isoform (a).

Source sequence(s)

AC022002, AK125460, AY090737, BM718335, CD697898, CN282428, DN991363, R42166

Consensus CDS

CCDS43041.1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35

Conserved Domains (4) summary

cd05853
Location:513 → 597

Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4

cd00063
Location:597 → 690

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd04969
Location:422 → 494

Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin

cl11960
Location:225 → 313

Ig; Immunoglobulin domain
NM_175607.3 → NP_783200.1 contactin-4 isoform a precursor

See identical proteins and their annotated locations for NP_783200.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 4 and 6 encode the same isoform (a).

Source sequence(s)

AC022002, AF464063, AF549455, AY090737, DA063654, DA796385, R42166

Consensus CDS

CCDS43041.1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35

Related

ENSP00000396010.1, ENST00000418658.6

Conserved Domains (4) summary

cd05853
Location:513 → 597

Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4

cd00063
Location:597 → 690

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd04969
Location:422 → 494

Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin

cl11960
Location:225 → 313

Ig; Immunoglobulin domain
NM_175613.3 → NP_783302.1 contactin-4 isoform c

See identical proteins and their annotated locations for NP_783302.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AC022002, AK314396, DB457029, R42166

Consensus CDS

CCDS2558.1

UniProtKB/TrEMBL

B3KQ34

Related

ENSP00000380600.2, ENST00000397459.6

Conserved Domains (5) summary

cd04969
Location:94 → 166

Ig5_Contactin_like; Fifth Ig domain of contactin

cd05853
Location:185 → 269

Ig6_Contactin-4; Sixth Ig domain of contactin-4

smart00410
Location:87 → 166

IG_like; Immunoglobulin like

cd00063
Location:269 → 362

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:4 → 73

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

2098866..3057959

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017005783.2 → XP_016861272.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35

Conserved Domains (4) summary

cd05853
Location:513 → 597

Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4

cd00063
Location:597 → 690

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd04969
Location:422 → 494

Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin

cl11960
Location:225 → 313

Ig; Immunoglobulin domain
XM_047447536.1 → XP_047303492.1 contactin-4 isoform X2
XM_011533427.3 → XP_011531729.1 contactin-4 isoform X1

See identical proteins and their annotated locations for XP_011531729.1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35

Conserved Domains (4) summary

cd05853
Location:513 → 597

Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4

cd00063
Location:597 → 690

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd04969
Location:422 → 494

Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin

cl11960
Location:225 → 313

Ig; Immunoglobulin domain
XM_017005785.2 → XP_016861274.1 contactin-4 isoform X2

Conserved Domains (5) summary

cd04969
Location:422 → 494

Ig5_Contactin_like; Fifth Ig domain of contactin

smart00410
Location:415 → 494

IG_like; Immunoglobulin like

cd00063
Location:596 → 689

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:26 → 117

I-set; Immunoglobulin I-set domain

cl11960
Location:513 → 596

Ig; Immunoglobulin domain
XM_017005782.2 → XP_016861271.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35

Conserved Domains (4) summary

cd05853
Location:513 → 597

Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4

cd00063
Location:597 → 690

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd04969
Location:422 → 494

Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin

cl11960
Location:225 → 313

Ig; Immunoglobulin domain
XM_011533425.4 → XP_011531727.1 contactin-4 isoform X1

See identical proteins and their annotated locations for XP_011531727.1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35

Conserved Domains (4) summary

cd05853
Location:513 → 597

Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4

cd00063
Location:597 → 690

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd04969
Location:422 → 494

Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin

cl11960
Location:225 → 313

Ig; Immunoglobulin domain
XM_006713004.5 → XP_006713067.1 contactin-4 isoform X2

Conserved Domains (5) summary

cd04969
Location:422 → 494

Ig5_Contactin_like; Fifth Ig domain of contactin

smart00410
Location:415 → 494

IG_like; Immunoglobulin like

cd00063
Location:596 → 689

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:26 → 117

I-set; Immunoglobulin I-set domain

cl11960
Location:513 → 596

Ig; Immunoglobulin domain
XM_017005784.3 → XP_016861273.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35

Conserved Domains (4) summary

cd05853
Location:513 → 597

Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4

cd00063
Location:597 → 690

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd04969
Location:422 → 494

Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin

cl11960
Location:225 → 313

Ig; Immunoglobulin domain
XM_047447535.1 → XP_047303491.1 contactin-4 isoform X2
XM_047447518.1 → XP_047303474.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447523.1 → XP_047303479.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447528.1 → XP_047303484.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447521.1 → XP_047303477.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447520.1 → XP_047303476.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447526.1 → XP_047303482.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447525.1 → XP_047303481.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447529.1 → XP_047303485.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447522.1 → XP_047303478.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447530.1 → XP_047303486.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447532.1 → XP_047303488.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447517.1 → XP_047303473.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447524.1 → XP_047303480.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447531.1 → XP_047303487.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447533.1 → XP_047303489.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447519.1 → XP_047303475.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447527.1 → XP_047303483.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447516.1 → XP_047303472.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_047447534.1 → XP_047303490.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_011533430.3 → XP_011531732.1 contactin-4 isoform X1

See identical proteins and their annotated locations for XP_011531732.1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35

Conserved Domains (4) summary

cd05853
Location:513 → 597

Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4

cd00063
Location:597 → 690

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd04969
Location:422 → 494

Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin

cl11960
Location:225 → 313

Ig; Immunoglobulin domain
XM_017005787.2 → XP_016861276.1 contactin-4 isoform X2

Conserved Domains (5) summary

cd04969
Location:422 → 494

Ig5_Contactin_like; Fifth Ig domain of contactin

smart00410
Location:415 → 494

IG_like; Immunoglobulin like

cd00063
Location:596 → 689

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:26 → 117

I-set; Immunoglobulin I-set domain

cl11960
Location:513 → 596

Ig; Immunoglobulin domain
XM_011533428.3 → XP_011531730.1 contactin-4 isoform X1

See identical proteins and their annotated locations for XP_011531730.1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35

Related

ENSP00000413642.1, ENST00000427331.5

Conserved Domains (4) summary

cd05853
Location:513 → 597

Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4

cd00063
Location:597 → 690

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd04969
Location:422 → 494

Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin

cl11960
Location:225 → 313

Ig; Immunoglobulin domain
XM_017005786.2 → XP_016861275.1 contactin-4 isoform X2

Conserved Domains (5) summary

cd04969
Location:422 → 494

Ig5_Contactin_like; Fifth Ig domain of contactin

smart00410
Location:415 → 494

IG_like; Immunoglobulin like

cd00063
Location:596 → 689

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:26 → 117

I-set; Immunoglobulin I-set domain

cl11960
Location:513 → 596

Ig; Immunoglobulin domain
XM_011533429.3 → XP_011531731.1 contactin-4 isoform X1

See identical proteins and their annotated locations for XP_011531731.1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35

Conserved Domains (4) summary

cd05853
Location:513 → 597

Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4

cd00063
Location:597 → 690

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd04969
Location:422 → 494

Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin

cl11960
Location:225 → 313

Ig; Immunoglobulin domain
XM_011533431.3 → XP_011531733.1 contactin-4 isoform X3

Conserved Domains (6) summary

cd04969
Location:411 → 483

Ig5_Contactin_like; Fifth Ig domain of contactin

cd05853
Location:502 → 586

Ig6_Contactin-4; Sixth Ig domain of contactin-4

smart00410
Location:404 → 483

IG_like; Immunoglobulin like

cd00063
Location:586 → 679

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:15 → 106

I-set; Immunoglobulin I-set domain

cl11960
Location:214 → 302

Ig; Immunoglobulin domain
XM_047447537.1 → XP_047303493.1 contactin-4 isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

2092772..3052283

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054345401.1 → XP_054201376.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345417.1 → XP_054201392.1 contactin-4 isoform X2
XM_054345402.1 → XP_054201377.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345416.1 → XP_054201391.1 contactin-4 isoform X2
XM_054345400.1 → XP_054201375.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345399.1 → XP_054201374.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345420.1 → XP_054201395.1 contactin-4 isoform X2
XM_054345406.1 → XP_054201381.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345410.1 → XP_054201385.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345412.1 → XP_054201387.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345413.1 → XP_054201388.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345407.1 → XP_054201382.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345409.1 → XP_054201384.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345408.1 → XP_054201383.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345411.1 → XP_054201386.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345405.1 → XP_054201380.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345414.1 → XP_054201389.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345423.1 → XP_054201398.1 contactin-4 isoform X5
XM_054345404.1 → XP_054201379.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345419.1 → XP_054201394.1 contactin-4 isoform X2
XM_054345403.1 → XP_054201378.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345418.1 → XP_054201393.1 contactin-4 isoform X2
XM_054345415.1 → XP_054201390.1 contactin-4 isoform X1

UniProtKB/Swiss-Prot

B2RAX3, Q8IWV2, Q8IX14, Q8TC35
XM_054345421.1 → XP_054201396.1 contactin-4 isoform X3
XM_054345422.1 → XP_054201397.1 contactin-4 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_175612.1: Suppressed sequence

Description

NM_175612.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.