PVT1 Pvt1 oncogene [Homo sapiens (human)] - Gene

Summary

Official Symbol: PVT1provided by HGNC
Official Full Name: Pvt1 oncogeneprovided by HGNC
Primary source: HGNC:HGNC:9709
See related: Ensembl:ENSG00000249859 MIM:165140; AllianceGenome:HGNC:9709
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TP53LC09; LINC00079; MIR1204HG; NCRNA00079; onco-lncRNA-100
Summary: This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015]
Expression: Broad expression in ovary (RPKM 3.9), bone marrow (RPKM 3.4) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q24.21

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (127794524..128101256)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (128922013..129229130)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (128806779..129113499)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long non-coding RNA (lncRNA) PVT1 in drug resistance of cancers: Focus on pathological mechanisms.
Title: Long non-coding RNA (lncRNA) PVT1 in drug resistance of cancers: Focus on pathological mechanisms.
Long noncoding RNA plasmacytoma variant translocation 1 is overexpressed in cutaneous squamous cell carcinoma and exon 2 is critical for its oncogenicity.
Title: Long noncoding RNA plasmacytoma variant translocation 1 is overexpressed in cutaneous squamous cell carcinoma and exon 2 is critical for its oncogenicity.
PVT1 interacts with polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma.
Title: PVT1 interacts with polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma.
LncRNA-PVT1 was identified as a key regulator for TMZ resistance and STAT-related pathway in glioma.
Title: LncRNA-PVT1 was identified as a key regulator for TMZ resistance and STAT-related pathway in glioma.
PVT1 lncRNA in lung cancer: A key player in tumorigenesis and therapeutic opportunities.
Title: PVT1 lncRNA in lung cancer: A key player in tumorigenesis and therapeutic opportunities.
Long noncoding RNA PVT1 predicts poor prognosis and promotes the progression of colorectal cancer through the miR-24-3p/NRP1 axis in zebrafish xenografts.
Title: Long noncoding RNA PVT1 predicts poor prognosis and promotes the progression of colorectal cancer through the miR-24-3p/NRP1 axis in zebrafish xenografts.
Dysregulation of PVT1 and NEAT1 lncRNAs in pituitary adenomas.
Title: Dysregulation of PVT1 and NEAT1 lncRNAs in pituitary adenomas.
LncRNA PVT1 promotes bladder cancer progression by forming a positive feedback loop with STAT5B.
Title: LncRNA PVT1 promotes bladder cancer progression by forming a positive feedback loop with STAT5B.
Identification of LncPVT1 and CircPVT1 as prognostic biomarkers in human colorectal polyps.
Title: Identification of LncPVT1 and CircPVT1 as prognostic biomarkers in human colorectal polyps.
LncRNA PVT1 Confers Cisplatin Resistance of Esophageal Cancer Cells through Modulating the miR-181a-5p-Glutaminase (GLS) Axis.
Title: LncRNA PVT1 Confers Cisplatin Resistance of Esophageal Cancer Cells through Modulating the miR-181a-5p-Glutaminase (GLS) Axis.

Submit: New GeneRIF Correction See all GeneRIFs (278)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A common variant at 8q24.21 is associated with renal cell cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). EBI GWAS Catalog EBI GWAS CatalogPubMed
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetics of rheumatoid arthritis contributes to biology and drug discovery. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of atypical psychosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S1087 (e-PCR)
- UniSTS:52483

SHGC-152351 (e-PCR)
- UniSTS:183057

D11S2977 (e-PCR)
- UniSTS:152096

AFMB299YE9 (e-PCR)
- UniSTS:45859

L17705 (e-PCR)
- UniSTS:66091

STS-T95511 (e-PCR)
- UniSTS:11578

SHGC-144185 (e-PCR)
- UniSTS:174158

G31084 (e-PCR)
- UniSTS:21331

SHGC-82342 (e-PCR)
- UniSTS:104307

SGC34443 (e-PCR)
- UniSTS:1412

G17834 (e-PCR)
- UniSTS:14735

D8S1720 (e-PCR), detects polymorphism
- UniSTS:58041

SHGC-151203 (e-PCR)
- UniSTS:173533

RH68431 (e-PCR)
- UniSTS:82936

Other Names

CXCR4/PVT1 fusion
HIST1H2BD/PVT1 fusion
MIR1204, MIR1205, MIR1206 and MIR1207 host
Oncogene PVT-1 (MYC activator)
PVT1/CASC8 fusion
PVT1/CCDC26 fusion
PVT1/IFRD1 fusion
PVT1/IRF2BP2 fusion
PVT1/LINC00824 fusion
PVT1/MYC fusion
PVT1/NFIL3 fusion
PVT1/NSMCE2 fusion
PVT1/SPRY2 fusion
PVT1/UBB fusion
Pvt1 oncogene (non-protein coding)
RP11-89K10/PVT1 fusion
long intergenic non-protein coding RNA 79
plasmacytoma variant translocation 1
pvt-1 (murine) oncogene homolog, MYC activator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.