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    ZNF461 zinc finger protein 461 [ Homo sapiens (human) ]

    Gene ID: 92283, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF461provided by HGNC
    Official Full Name
    zinc finger protein 461provided by HGNC
    Primary source
    HGNC:HGNC:21629
    See related
    Ensembl:ENSG00000197808 MIM:608640; AllianceGenome:HGNC:21629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GIOT1; HZF28; GIOT-1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 1.8), thyroid (RPKM 1.6) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19q13.12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36636618..36666837, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39311920..39342122, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37127520..37157739, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14527 Neighboring gene ZNF529 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14529 Neighboring gene zinc finger protein 382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14530 Neighboring gene zinc finger protein 567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37178931-37179570 Neighboring gene ZNF567 divergent transcript Neighboring gene zinc finger protein 850 Neighboring gene Sharpr-MPRA regulatory region 9870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14532

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-->q13.4. Dai J, et al. Cytogenet Genome Res, 2003. PMID 15004467
    2. Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family. Mizutani T, et al. Mol Endocrinol, 2001 Oct. PMID 11579202
    3. Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells. Kajitani T, et al. Endocrinology, 2004 May. PMID 14764631
    4. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. Abrink M, et al. DNA Cell Biol, 1995 Feb. PMID 7865130
    5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular cloning and tissue distribution of ZNF461.
      Title: Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-->q13.4.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC33911

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 461
    Names
    gonadotropin-inducible ovary transcription repressor 1
    zinc finger protein 28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297623.3 → NP_001284552.1  zinc finger protein 461 isoform 2

      See identical proteins and their annotated locations for NP_001284552.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AB021641, AC074138, AK299370
      Consensus CDS
      CCDS74348.1
      UniProtKB/TrEMBL
      B4DRP8
      Related
      ENSP00000353515.4, ENST00000360357.8
      Conserved Domains (4) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:289 → 492
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:420 → 440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:264 → 289
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001322821.2 → NP_001309750.1  zinc finger protein 461 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC074138
      Conserved Domains (5) summary
      smart00349
      Location:2 → 60
      KRAB; krueppel associated box
      COG5048
      Location:306 → 509
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:437 → 457
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2 → 39
      KRAB; KRAB box
      pfam13465
      Location:449 → 472
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001322823.2 → NP_001309752.1  zinc finger protein 461 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC074138, BX649031, DC339675
      Conserved Domains (4) summary
      COG5048
      Location:281 → 484
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:412 → 432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:256 → 281
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:15 → 35
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    4. NM_001322825.2 → NP_001309754.1  zinc finger protein 461 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC074138
      Conserved Domains (4) summary
      COG5048
      Location:281 → 484
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:412 → 432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:256 → 281
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:15 → 35
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    5. NM_001322826.2 → NP_001309755.1  zinc finger protein 461 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC074138
      Conserved Domains (4) summary
      COG5048
      Location:258 → 461
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:389 → 409
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:233 → 258
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:15 → 35
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    6. NM_001322827.2 → NP_001309756.1  zinc finger protein 461 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC074138
      Conserved Domains (4) summary
      COG5048
      Location:258 → 461
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:389 → 409
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:233 → 258
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:15 → 35
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    7. NM_001322828.2 → NP_001309757.1  zinc finger protein 461 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC074138, DC308305, DC339675
      Conserved Domains (3) summary
      COG5048
      Location:224 → 427
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:355 → 375
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:199 → 224
      zf-H2C2_2; Zinc-finger double domain

    8. NM_153257.5 → NP_694989.2  zinc finger protein 461 isoform 1

      See identical proteins and their annotated locations for NP_694989.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB021641, AC074138, AK299370, AY329493
      Consensus CDS
      CCDS54257.1
      UniProtKB/Swiss-Prot
      A8K9W9, Q6VSF7, Q8TAF7, Q9ULZ8
      Related
      ENSP00000467931.1, ENST00000588268.6
      Conserved Domains (4) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:312 → 515
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:287 → 312
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      36636618..36666837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527486.3 → XP_011525788.1  zinc finger protein 461 isoform X1

      See identical proteins and their annotated locations for XP_011525788.1

      UniProtKB/Swiss-Prot
      Q8TAF7
      Conserved Domains (2) summary
      COG5048
      Location:200 → 388
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_047439680.1 → XP_047295636.1  zinc finger protein 461 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      39311920..39342122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322609.1 → XP_054178584.1  zinc finger protein 461 isoform X1

    2. XM_054322610.1 → XP_054178585.1  zinc finger protein 461 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TAF7.2 GenPept UniProtKB/Swiss-Prot:Q8TAF7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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