GPC5 glypican 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPC5provided by HGNC
Official Full Name: glypican 5provided by HGNC
Primary source: HGNC:HGNC:4453
See related: Ensembl:ENSG00000179399 MIM:602446; AllianceGenome:HGNC:4453
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 1.8), testis (RPKM 1.4) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q31.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (91398621..92867237)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (90601154..92070908)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (92050875..93519490)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion.
Title: GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion.
Glypican-1, -3, -5 (GPC1, GPC3, GPC5) and Hedgehog Pathway Expression in Oral Squamous Cell Carcinoma.
Title: Glypican-1, -3, -5 (GPC1, GPC3, GPC5) and Hedgehog Pathway Expression in Oral Squamous Cell Carcinoma.
Subcellular localization of glypican-5 is associated with dynamic motility of the human mesenchymal stem cell line U3DT.
Title: Subcellular localization of glypican-5 is associated with dynamic motility of the human mesenchymal stem cell line U3DT.
miR-301b represses the proliferation and invasion of glioma cells by up-regulating GPC5 expression
Title: MicroRNA-301b promotes the proliferation and invasion of glioma cells through enhancing activation of Wnt/β-catenin signaling via targeting Glypican-5.
Hotair promoted Gastric Cancer development by promoting GCP5 expression via sponging miR-217.
Title: Long non-coding RNA Hotair promotes gastric cancer progression via miR-217-GPC5 axis.
Our results showed that GPC5 was lowly expressed in PCa cell lines.
Title: Overexpression of Glypican 5 (GPC5) Inhibits Prostate Cancer Cell Proliferation and Invasion via Suppressing Sp1-Mediated EMT and Activation of Wnt/β-Catenin Signaling.
Taken together, our results suggest GPC5 as a tumor suppressor in PDAC and its expression is possibly regulated by miR-4295. Our study indicates that the miR-4295/GPC5 axis may play an important role in the pathogenesis of PADC and has potential applications for the development of PDAC therapy.
Title: High expression of microRNA-4295 contributes to cell proliferation and invasion of pancreatic ductal adenocarcinoma by the down-regulation of Glypican-5.
Suggest that GPC5 is able to suppress the lung adenocarcinoma metastasis by competitively binding to Wnt3a and inactivating the Wnt/beta-catenin signaling pathway.
Title: Glypican-5 suppresses Epithelial-Mesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a.
GPC5 is a novel epigenetically silenced tumor suppressor, which inhibits tumor growth by suppressing Wnt/beta-catenin signaling in lung adenocarcinoma.
Title: GPC5, a novel epigenetically silenced tumor suppressor, inhibits tumor growth by suppressing Wnt/β-catenin signaling in lung adenocarcinoma.
GPC5 protein expression showed a close correlation with the tumorigenesis and tumor progression of prostate cancer, and that might be applied as a novel biomarker for the prediction of diagnosis and prognosis of prostate cancer.
Title: Prognostic significance of GPC5 expression in patients with prostate cancer.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2012-03-08) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2012-03-08) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variation in GPC5 is associated with acquired nephrotic syndrome. EBI GWAS Catalog EBI GWAS CatalogPubMed
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host determinants of HIV-1 control in African Americans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13S907 (e-PCR)
- UniSTS:63235

D10S2412 (e-PCR)
- UniSTS:52998

G09432 (e-PCR)
- UniSTS:30215

WI-15916 (e-PCR)
- UniSTS:76298

D13S1690 (e-PCR)
- UniSTS:78354

RH119939 (e-PCR)
- UniSTS:133141

SGC34864 (e-PCR)
- UniSTS:1827

SHGC-51851 (e-PCR)
- UniSTS:13098

GDB:314231 (e-PCR)
- UniSTS:156468

RH65549 (e-PCR)
- UniSTS:33332

G29145 (e-PCR)
- UniSTS:22840

G29128 (e-PCR)
- UniSTS:82490

SHGC-152222 (e-PCR)
- UniSTS:183354

STS-T81306 (e-PCR)
- UniSTS:7485

D13S140 (e-PCR)
- UniSTS:15933

PMC140024P17 (e-PCR)
- UniSTS:270913

PMC140024P18 (e-PCR)
- UniSTS:270914

PMC140024P19 (e-PCR)
- UniSTS:270915

PMC140024P20 (e-PCR)
- UniSTS:270917

PMC140024P21 (e-PCR)
- UniSTS:270918

PMC140024P23 (e-PCR)
- UniSTS:270920

D13S1490 (e-PCR)
- UniSTS:21322

SHGC-12990 (e-PCR)
- UniSTS:48202

SHGC-143319 (e-PCR)
- UniSTS:171852

RH104318 (e-PCR)
- UniSTS:98643

G54646 (e-PCR)
- UniSTS:117847

SHGC-53712 (e-PCR)
- UniSTS:77664

SHGC-151150 (e-PCR)
- UniSTS:173408

SHGC-80699 (e-PCR)
- UniSTS:102243

RH121340 (e-PCR)
- UniSTS:138604

D13S899 (e-PCR)
- UniSTS:18031

A009W27 (e-PCR)
- UniSTS:57457

NoName (e-PCR)
- UniSTS:61556

SHGC-86335 (e-PCR)
- UniSTS:104059

SHGC-86221 (e-PCR)
- UniSTS:104844

SHGC-4700 (e-PCR)
- UniSTS:29069

SHGC-112363 (e-PCR)
- UniSTS:182676

RH77946 (e-PCR)
- UniSTS:80022

D13S1300 (e-PCR), detects polymorphism
- UniSTS:71328

SHGC-145290 (e-PCR)
- UniSTS:174496

STS-T98842 (e-PCR)
- UniSTS:64939

RH93789 (e-PCR)
- UniSTS:90801

D13S795 (e-PCR), detects polymorphism
- UniSTS:25785

RH122663 (e-PCR)
- UniSTS:135113

SHGC-83508 (e-PCR)
- UniSTS:103374

D13S1811 (e-PCR), detects polymorphism
- UniSTS:62926

SHGC-32622 (e-PCR)
- UniSTS:38355

SHGC-52670 (e-PCR)
- UniSTS:15829

SHGC-81144 (e-PCR)
- UniSTS:102357

SHGC-84151 (e-PCR)
- UniSTS:104671

SHGC-37261 (e-PCR)
- UniSTS:40927

D13S1669 (e-PCR)
- UniSTS:50655

SHGC-81110 (e-PCR)
- UniSTS:182754

G32919 (e-PCR)
- UniSTS:117497

L17986 (e-PCR)
- UniSTS:79610

SHGC-84210 (e-PCR)
- UniSTS:104699

RH120664 (e-PCR)
- UniSTS:132605

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization to membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in lysosomal lumen	TAS Traceable Author Statement more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glypican-5

Names: bA93M14.1; glypican proteoglycan 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.