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    FNTA farnesyltransferase, CAAX box, subunit alpha [ Homo sapiens (human) ]

    Gene ID: 2339, updated on 2-Nov-2024

    Summary

    Official Symbol
    FNTAprovided by HGNC
    Official Full Name
    farnesyltransferase, CAAX box, subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:3782
    See related
    Ensembl:ENSG00000168522 MIM:134635; AllianceGenome:HGNC:3782
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FPTA; PTAR2; PGGT1A
    Summary
    Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in fat (RPKM 32.7), placenta (RPKM 27.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See FNTA in Genome Data Viewer
    Location:
    8p11.21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (43056323..43085785)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (43325268..43354718)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (42911466..42940928)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 170 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:42750865-42751426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19161 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:42774215-42774934 Neighboring gene microRNA 4469 Neighboring gene hook microtubule tethering protein 3 Neighboring gene MPRA-validated peak7007 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:42888473-42889024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19162 Neighboring gene RNA, U1 small nuclear 124, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27321 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:42947622-42948528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:42948529-42949434 Neighboring gene NANOG hESC enhancer GRCh37_chr8:42971985-42972543 Neighboring gene protein O-mannose kinase Neighboring gene Sharpr-MPRA regulatory region 5985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19166 Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene RNY5 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of farnesyltransferase, CAAX box, alpha (FNTA) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Geranylgeranyltransferase-1 modulates both p24CA release and intracellular Gag in TNF-alpha-stimulated U1 cells PubMed
    capsid gag Geranylgeranyltransferase-1 modulates both p24CA release and intracellular Gag in TNF-alpha-stimulated U1 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC99680

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of CAAX-protein geranylgeranyltransferase complex  
    part_of CAAX-protein geranylgeranyltransferase complex PubMed 
    part_of CAAX-protein geranylgeranyltransferase complex PubMed 
    is_active_in cytoplasm  
    located_in cytosol  
    part_of microtubule associated complex PubMed 
    located_in plasma membrane  
    part_of protein farnesyltransferase complex  
    part_of protein farnesyltransferase complex PubMed 

    General protein information

    Preferred Names
    protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
    Names
    FTase-alpha
    GGTase-I-alpha
    farnesyl-protein transferase alpha-subunit
    farnesyltransferase, CAAX box, alpha
    protein prenyltransferase alpha subunit repeat containing 2
    ras proteins prenyltransferase subunit alpha
    type I protein geranyl-geranyltransferase alpha subunit
    NP_002018.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002027.3NP_002018.1  protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

      See identical proteins and their annotated locations for NP_002018.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      BC084566, BI913631
      Consensus CDS
      CCDS6140.1
      UniProtKB/Swiss-Prot
      A6NJW0, P49354, Q53XJ9, Q9UDC1
      Related
      ENSP00000303423.3, ENST00000302279.8
      Conserved Domains (1) summary
      PLN02789
      Location:64365
      PLN02789; farnesyltranstransferase

    RNA

    1. NR_033698.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate internal exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC084566, BI913631, BM686906

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      43056323..43085785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      43325268..43354718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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