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    RNF10 ring finger protein 10 [ Homo sapiens (human) ]

    Gene ID: 9921, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RNF10provided by HGNC
    Official Full Name
    ring finger protein 10provided by HGNC
    Primary source
    HGNC:HGNC:10055
    See related
    Ensembl:ENSG00000022840 MIM:615998; AllianceGenome:HGNC:10055
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RIE2
    Summary
    The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 52.4), bone marrow (RPKM 51.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RNF10 in Genome Data Viewer
    Location:
    12q24.31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120534356..120577588)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120523536..120566717)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120972159..121015391)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene dynein light chain LC8-type 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120933574-120934240 Neighboring gene negative regulator of antiviral response Neighboring gene coenzyme Q5, methyltransferase Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120965951-120966721 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120966722-120967491 Neighboring gene ribosomal protein L29 pseudogene 24 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120972057-120972210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4954 Neighboring gene uncharacterized LOC128071547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4956 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121028475-121029374 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121029375-121030273 Neighboring gene POP5 homolog, ribonuclease P/MRP subunit Neighboring gene ribosomal protein L11 pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation. Cao X, et al. FEBS Open Bio, 2021 Feb. PMID 33249776, Free PMC Article
    2. iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation. Garshott DM, et al. Cell Rep, 2021 Aug 31. PMID 34469731, Free PMC Article
    3. The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation. Garzia A, et al. Cell Rep, 2021 Aug 3. PMID 34348161
    4. Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes. Huang K, et al. Obesity (Silver Spring), 2014 Apr. PMID 24151200, Free PMC Article
    5. cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein. Seki N, et al. J Hum Genet, 2000. PMID 10697961

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircRNA RNF10 inhibits tumorigenicity by targeting miR-942-5p/GOLIM4 axis in breast cancer.
      Title: CircRNA RNF10 inhibits tumorigenicity by targeting miR-942-5p/GOLIM4 axis in breast cancer.
    2. The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation.
      Title: The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation.
    3. Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.
      Title: Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.
    4. CYB5A, which has a role in stearyl-CoA-desaturase activity, and RNF10, with an unknown role in weight regulating pathways, associated with adiposity and nominally increased the risk for T2D in American Indians.
      Title: Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes.
    5. RNF10 is a trans-acting protein regulating MAG expression and is required for myelin formation.
      Title: A novel function of RING finger protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells.
    6. MEOX2 and Meox2 binding to RNF10 protein was characterized.
      Title: Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    New susceptibility loci associated with kidney disease in type 1 diabetes.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of ring finger protein 10 (RNF10) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0262, MGC126758, MGC126764

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of Schwann cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of myelination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in postsynapse to nucleus signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extrinsic component of postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF10
    Names
    epididymis secretory sperm binding protein
    NP_001317403.1
    NP_055683.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330474.2 → NP_001317403.1  E3 ubiquitin-protein ligase RNF10 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is longer, but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AB027196, BQ015862, BU184035, DA956437, HY376488
      Consensus CDS
      CCDS81746.1
      UniProtKB/TrEMBL
      B3KSN5, B3KUR9
      Related
      ENSP00000415682.2, ENST00000413266.6
      Conserved Domains (1) summary
      pfam13923
      Location:225 → 266
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    2. NM_014868.5 → NP_055683.3  E3 ubiquitin-protein ligase RNF10 isoform 1

      See identical proteins and their annotated locations for NP_055683.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      BC016622, BQ015862, DA103961, DB526099
      Consensus CDS
      CCDS9201.1
      UniProtKB/Swiss-Prot
      Q8N5U6, Q92550, Q9NPP8, Q9ULW4
      UniProtKB/TrEMBL
      A0A024RBP0, B3KSN5, B3KUR9
      Related
      ENSP00000322242.4, ENST00000325954.9
      Conserved Domains (1) summary
      cd16536
      Location:225 → 267
      RING-HC_RNF10; RING finger, HC subclass, found in RING finger protein 10 (RNF10) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      120534356..120577588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      120523536..120566717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N5U6.2 GenPept UniProtKB/Swiss-Prot:Q8N5U6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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