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    KLF8 KLF transcription factor 8 [ Homo sapiens (human) ]

    Gene ID: 11279, updated on 5-Mar-2024

    Summary

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    Official Symbol
    KLF8provided by HGNC
    Official Full Name
    KLF transcription factor 8provided by HGNC
    Primary source
    HGNC:HGNC:6351
    See related
    Ensembl:ENSG00000102349 MIM:300286; AllianceGenome:HGNC:6351
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BKLF3; ZNF741
    Summary
    This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
    Expression
    Broad expression in skin (RPKM 8.2), fat (RPKM 3.4) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    Xp11.21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (55908123..56291531)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (55201315..55584861)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55934556..56317964)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chrX:55700255-55700456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29682 Neighboring gene XAGE-4 protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20868 Neighboring gene Ras related GTP binding B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29684 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:55945424-55946623 Neighboring gene uncharacterized LOC124905192 Neighboring gene uncharacterized LOC124905193 Neighboring gene GOT2 pseudogene 6 Neighboring gene uncharacterized LOC124900486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:56140677-56141176 Neighboring gene ribosomal protein L23a pseudogene 83 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:56589763-56590390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29688 Neighboring gene uncharacterized LOC124905194 Neighboring gene ubiquilin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. KLF8 is activated by TGF-β1 via Smad2 and contributes to ovarian cancer progression. Cherukunnath A, et al. J Cell Biochem, 2022 May. PMID 35293014
    2. CircRNA PVT1 promotes proliferation and chemoresistance of osteosarcoma cells via the miR-24-3p/KLF8 axis. Wang B, et al. Int J Clin Oncol, 2022 Apr. PMID 35171359
    3. Krüppel-like factor 8 regulates VEGFA expression and angiogenesis in hepatocellular carcinoma. Cheng S, et al. Sci Rep, 2018 Nov 27. PMID 30479372, Free PMC Article
    4. Krüppel-Like Factor 8 Overexpression Correlates with Poor Prognosis in Non-Small Cell Lung Cancer. Li J, et al. Pathol Oncol Res, 2019 Jan. PMID 28986741
    5. KLF8 knockdown triggered growth inhibition and induced cell phase arrest in human pancreatic cancer cells. Yi X, et al. Gene, 2016 Jul 1. PMID 26995652

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KLF8 Promotes the Survival of Lung Adenocarcinoma During Nutrient Deprivation by Regulating the Pentose Phosphate Pathway through SIRT2.
      Title: KLF8 Promotes the Survival of Lung Adenocarcinoma During Nutrient Deprivation by Regulating the Pentose Phosphate Pathway through SIRT2.
    2. CircRNA PVT1 promotes proliferation and chemoresistance of osteosarcoma cells via the miR-24-3p/KLF8 axis.
      Title: CircRNA PVT1 promotes proliferation and chemoresistance of osteosarcoma cells via the miR-24-3p/KLF8 axis.
    3. KLF8 is activated by TGF-beta1 via Smad2 and contributes to ovarian cancer progression.
      Title: KLF8 is activated by TGF-β1 via Smad2 and contributes to ovarian cancer progression.
    4. Oncogenic E3 ubiquitin ligase NEDD4 binds to KLF8 and regulates the microRNA-132/NRF2 axis in bladder cancer.
      Title: Oncogenic E3 ubiquitin ligase NEDD4 binds to KLF8 and regulates the microRNA-132/NRF2 axis in bladder cancer.
    5. miR-24-3p/KLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT.
      Title: miR-24-3p/KLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT.
    6. Circ_0067934 promotes non-small cell lung cancer development by regulating miR-1182/KLF8 axis and activating Wnt/beta-catenin pathway.
      Title: Circ_0067934 promotes non-small cell lung cancer development by regulating miR-1182/KLF8 axis and activating Wnt/β-catenin pathway.
    7. Upregulated miRNA-1236-3p in osteosarcoma inhibits cell proliferation and induces apoptosis via targeting KLF8.
      Title: Upregulated miRNA-1236-3p in osteosarcoma inhibits cell proliferation and induces apoptosis via targeting KLF8.
    8. KLF8 promotes cancer stem cell-like phenotypes in osteosarcoma through miR-429-SOX2 signaling.
      Title: KLF8 promotes cancer stem cell-like phenotypes in osteosarcoma through miR-429-SOX2 signaling.
    9. KLF8 is associated with poor prognosis and regulates glycolysis by targeting GLUT4 in gastric cancer.
      Title: KLF8 is associated with poor prognosis and regulates glycolysis by targeting GLUT4 in gastric cancer.
    10. KLF8-overexpressing hepatocellular carcinoma cells had a higher potential for inducing angiogenesis. The up-regulation of KLF8 increased VEGFA protein levels and induced VEGFA promoter activity by binding to the CACCC region of the VEGFA promoter.
      Title: Krüppel-like factor 8 regulates VEGFA expression and angiogenesis in hepatocellular carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (47)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-10-12)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-10-12)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC138314, DKFZp686O08126

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in aggresome IDA
    Inferred from Direct Assay
    more info
    		  
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    Krueppel-like factor 8
    Names
    Kruppel like factor 8
    basic krueppel-like factor 3
    basic kruppel-like factor 3
    zinc finger protein 741

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011949.2 RefSeqGene

      Range
      329234..388409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001159296.2 → NP_001152768.1  Krueppel-like factor 8 isoform 2

      See identical proteins and their annotated locations for NP_001152768.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 3' coding region that causes a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK296156, AL050309, BX322609, DA874419
      Consensus CDS
      CCDS55428.1
      UniProtKB/Swiss-Prot
      O95600
      Related
      ENSP00000364063.3, ENST00000374928.7
      Conserved Domains (1) summary
      cl40450
      Location:48 → 216
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    2. NM_001324099.1 → NP_001311028.1  Krueppel-like factor 8 isoform 3

      Status: REVIEWED

      Source sequence(s)
      BC105130, BX322609, HF546208
      Consensus CDS
      CCDS87749.1
      UniProtKB/Swiss-Prot
      O95600
      Related
      ENSP00000492126.1, ENST00000640927.1
      Conserved Domains (1) summary
      cl40450
      Location:43 → 211
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    3. NM_001324100.1 → NP_001311029.1  Krueppel-like factor 8 isoform 4

      Status: REVIEWED

      Source sequence(s)
      BC105130, BX322609, HF546209
      UniProtKB/Swiss-Prot
      O95600
      Conserved Domains (4) summary
      COG5048
      Location:218 → 271
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:222 → 244
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:220 → 244
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:236 → 261
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001324102.1 → NP_001311031.1  Krueppel-like factor 8 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL050309, BX322609
      Consensus CDS
      CCDS14373.1
      UniProtKB/Swiss-Prot
      B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4
      Conserved Domains (4) summary
      COG5048
      Location:220 → 346
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:276 → 298
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:320 → 345
      zf-H2C2_2; Zinc-finger double domain
      cd21440
      Location:48 → 216
      KLF8_N; N-terminal domain of Kruppel-like factor 8

    5. NM_001324104.1 → NP_001311033.1  Krueppel-like factor 8 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) initiates at an upstream promoter compared to variant 1.
      Source sequence(s)
      AL050309, AL353698, AL445472, BX322609

    6. NM_001324105.1 → NP_001311034.1  Krueppel-like factor 8 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) initiates at an upstream promoter compared to variant 1.
      Source sequence(s)
      AL050309, AL445472, BX322609
      Conserved Domains (4) summary
      COG5048
      Location:269 → 339
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:273 → 295
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:317 → 342
      zf-H2C2_2; Zinc-finger double domain
      cd21440
      Location:45 → 213
      KLF8_N; N-terminal domain of Kruppel-like factor 8

    7. NM_007250.5 → NP_009181.2  Krueppel-like factor 8 isoform 1

      See identical proteins and their annotated locations for NP_009181.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AL050309, BC105130, BX322609
      Consensus CDS
      CCDS14373.1
      UniProtKB/Swiss-Prot
      B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4
      Related
      ENSP00000417303.1, ENST00000468660.6
      Conserved Domains (4) summary
      COG5048
      Location:220 → 346
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:276 → 298
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:320 → 345
      zf-H2C2_2; Zinc-finger double domain
      cd21440
      Location:48 → 216
      KLF8_N; N-terminal domain of Kruppel-like factor 8

    RNA

    1. NR_136704.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BC031355, BC105130, BX322609

    2. NR_136705.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AB209004, AL050309, BX322609

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      55908123..56291531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441797.1 → XP_047297753.1  Krueppel-like factor 8 isoform X1

      UniProtKB/Swiss-Prot
      B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

    2. XM_047441798.1 → XP_047297754.1  Krueppel-like factor 8 isoform X1

      UniProtKB/Swiss-Prot
      B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

    3. XM_006724575.3 → XP_006724638.1  Krueppel-like factor 8 isoform X3

      See identical proteins and their annotated locations for XP_006724638.1

      UniProtKB/Swiss-Prot
      O95600
      Conserved Domains (1) summary
      cl40450
      Location:48 → 216
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    4. XM_017029250.3 → XP_016884739.1  Krueppel-like factor 8 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:267 → 337
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 293
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:269 → 293
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:315 → 340
      zf-H2C2_2; Zinc-finger double domain

    5. XM_047441795.1 → XP_047297751.1  Krueppel-like factor 8 isoform X1

      UniProtKB/Swiss-Prot
      B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

    6. XM_047441799.1 → XP_047297755.1  Krueppel-like factor 8 isoform X1

      UniProtKB/Swiss-Prot
      B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

    7. XM_047441796.1 → XP_047297752.1  Krueppel-like factor 8 isoform X1

      UniProtKB/Swiss-Prot
      B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

    8. XM_047441800.1 → XP_047297756.1  Krueppel-like factor 8 isoform X2

    9. XM_024452332.2 → XP_024308100.1  Krueppel-like factor 8 isoform X4

      UniProtKB/TrEMBL
      Q05BZ3
      Related
      ENSP00000431911.1, ENST00000358094.7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      55201315..55584861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326416.1 → XP_054182391.1  Krueppel-like factor 8 isoform X2

    2. XM_054326412.1 → XP_054182387.1  Krueppel-like factor 8 isoform X1

      UniProtKB/Swiss-Prot
      B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

    3. XM_054326413.1 → XP_054182388.1  Krueppel-like factor 8 isoform X1

      UniProtKB/Swiss-Prot
      B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

    4. XM_054326417.1 → XP_054182392.1  Krueppel-like factor 8 isoform X2

    5. XM_054326418.1 → XP_054182393.1  Krueppel-like factor 8 isoform X2

    6. XM_054326410.1 → XP_054182385.1  Krueppel-like factor 8 isoform X1

      UniProtKB/Swiss-Prot
      B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

    7. XM_054326414.1 → XP_054182389.1  Krueppel-like factor 8 isoform X1

      UniProtKB/Swiss-Prot
      B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

    8. XM_054326411.1 → XP_054182386.1  Krueppel-like factor 8 isoform X1

      UniProtKB/Swiss-Prot
      B4DJN3, E7EQQ8, L0R3U8, L0R4U2, O95600, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4

    9. XM_054326419.1 → XP_054182394.1  Krueppel-like factor 8 isoform X3

    10. XM_054326415.1 → XP_054182390.1  Krueppel-like factor 8 isoform X2

    11. XM_054326420.1 → XP_054182395.1  Krueppel-like factor 8 isoform X4

      UniProtKB/TrEMBL
      Q05BZ3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95600.2 GenPept UniProtKB/Swiss-Prot:O95600

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