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    C16orf87 chromosome 16 open reading frame 87 [ Homo sapiens (human) ]

    Gene ID: 388272, updated on 19-Sep-2024

    Summary

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    Official Symbol
    C16orf87provided by HGNC
    Official Full Name
    chromosome 16 open reading frame 87provided by HGNC
    Primary source
    HGNC:HGNC:33754
    See related
    Ensembl:ENSG00000155330 AllianceGenome:HGNC:33754
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in testis (RPKM 20.7), bone marrow (RPKM 11.7) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See C16orf87 in Genome Data Viewer
    Location:
    16q11.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (46796603..46831180, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (52593496..52628075, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (46830515..46865092, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene myosin light chain kinase 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:46760810-46761360 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:46769513-46770212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10773 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:46781193-46782042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:46790891-46791426 Neighboring gene NANOG hESC enhancer GRCh37_chr16:46802782-46803317 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:46811535-46812050 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:46812051-46812566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10774 Neighboring gene NFE2 like bZIP transcription factor 3 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10777 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7435 Neighboring gene MPRA-validated peak2574 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:46877721-46878246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:46878247-46878770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10778 Neighboring gene Sharpr-MPRA regulatory region 14543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10779 Neighboring gene creatine kinase B pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:46903238-46903844 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:46903845-46904450 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:46917671-46918263 Neighboring gene small nucleolar RNA, C/D box 148 Neighboring gene glutamic--pyruvic transaminase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells. Miotto B, et al. Nucleic Acids Res, 2018 May 18. PMID 29490077, Free PMC Article
    2. Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner. Vélot L, et al. Mol Cell Proteomics, 2021. PMID 33640491, Free PMC Article
    3. The functional interactome landscape of the human histone deacetylase family. Joshi P, et al. Mol Syst Biol, 2013. PMID 23752268, Free PMC Article
    4. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. Nakamura K, et al. Nat Cell Biol, 2019 Mar. PMID 30804502, Free PMC Article
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC62018

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UPF0547 protein C16orf87

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001436.4 → NP_001001436.1  UPF0547 protein C16orf87 isoform 1

      See identical proteins and their annotated locations for NP_001001436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC007225, BC056676, BX647945
      Consensus CDS
      CCDS10724.1
      UniProtKB/Swiss-Prot
      Q63HN9, Q6PH81
      Related
      ENSP00000285697.4, ENST00000285697.9
      Conserved Domains (1) summary
      pfam10571
      Location:14 → 38
      UPF0547; Uncharacterized protein family UPF0547

    2. NM_001348660.2 → NP_001335589.1  UPF0547 protein C16orf87 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC007225
      Consensus CDS
      CCDS86522.1
      UniProtKB/Swiss-Prot
      Q6PH81
      Related
      ENSP00000378285.2, ENST00000394806.6
      Conserved Domains (1) summary
      pfam10571
      Location:14 → 38
      UPF0547; Uncharacterized protein family UPF0547

    3. NM_001348661.2 → NP_001335590.1  UPF0547 protein C16orf87 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon and contains another alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC007225
      Conserved Domains (1) summary
      pfam10571
      Location:14 → 38
      UPF0547; Uncharacterized protein family UPF0547

    RNA

    1. NR_145834.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007225, BX647945, HY180978

    2. NR_145835.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007225

    3. NR_145836.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007225, BX647945, DB460878

    4. NR_145837.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007225

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      46796603..46831180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      52593496..52628075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PH81.1 GenPept UniProtKB/Swiss-Prot:Q6PH81

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