PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PIK3R1provided by HGNC
Official Full Name: phosphoinositide-3-kinase regulatory subunit 1provided by HGNC
Primary source: HGNC:HGNC:8979
See related: Ensembl:ENSG00000145675 MIM:171833; AllianceGenome:HGNC:8979
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p85; AGM7; GRB1; IMD36; p85alpha; p85-ALPHA
Summary: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Expression: Ubiquitous expression in fat (RPKM 16.6), brain (RPKM 16.6) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q13.1

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (68215756..68301821)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (69037928..69124117)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (67511584..67597649)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PHLPP2 gene L1016S (rs61733127) and PIK3R1 gene Met326Ile (rs3730089) polymorphisms are associated with the risk of colon and breast cancers.
Title: PHLPP2 gene L1016S (rs61733127) and PIK3R1 gene Met326Ile (rs3730089) polymorphisms are associated with the risk of colon and breast cancers.
Lnc-PIK3R1, transcriptionally suppressed by YY1, inhibits hepatocellular carcinoma progression via the Lnc-PIK3R1/miR-1286/GSK3beta axis.
Title: Lnc-PIK3R1, transcriptionally suppressed by YY1, inhibits hepatocellular carcinoma progression via the Lnc-PIK3R1/miR-1286/GSK3β axis.
A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism.
Title: A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism.
Comparative genomic analysis of PIK3R1-mutated and wild-type breast cancers.
Title: Comparative genomic analysis of PIK3R1-mutated and wild-type breast cancers.
Clinicopathological analysis of rosette-forming glioneuronal tumors.
Title: Clinicopathological analysis of rosette-forming glioneuronal tumors.
Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway inactivation.
Title: Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway inactivation.
SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.
Title: SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.
FBXO21 mediated degradation of p85alpha regulates proliferation and survival of acute myeloid leukemia.
Title: FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia.
Role of PI3K/Akt/mTOR pathway-mediated macrophage autophagy in affecting the phenotype transformation of lung fibroblasts induced by silica dust exposure.
Title: Role of PI3K/Akt/mTOR pathway-mediated macrophage autophagy in affecting the phenotype transformation of lung fibroblasts induced by silica dust exposure.
The Role of PIK3R1 in Metabolic Function and Insulin Sensitivity.
Title: The Role of PIK3R1 in Metabolic Function and Insulin Sensitivity.

Submit: New GeneRIF Correction See all GeneRIFs (224)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Agammaglobulinemia 7, autosomal recessive MedGen: C3554689 OMIM: 615214 GeneReviews: Not available	not available
Immunodeficiency 36 MedGen: C4014934 OMIM: 616005 GeneReviews: Not available	not available
SHORT syndrome MedGen: C0878684 OMIM: 269880 GeneReviews: SHORT Syndrome	not available

EBI GWAS Catalog

Description
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of age at menarche in African-American women. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes	PubMed
	env	CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn	PubMed
	env	Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production	PubMed
	env	Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling	PubMed
	env	CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway	PubMed
	env	Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways	PubMed
	env	HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors	PubMed
	env	HIV-1 gp120-induced TNF-alpha production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways	PubMed
	env	HIV-1 gp120 induces an increase in tyrosine phosphorylation of two proteins, p56lck and phosphatidylinositol 3-kinase (PI 3-kinase) p85 alpha, that are physically complexed to the CD4 molecule	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity	PubMed
	env	PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells	PubMed
Nef	nef	HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells	PubMed
	nef	Diaminoquinoxaline benzenesulfonamide (DQBS) treatment reduces the amount of both HCK and the p85 regulatory subunit of PI3K associated with HIV-1 Nef and completely blocks Nef-dependent activation of ZAP-70	PubMed
	nef	In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase	PubMed
	nef	The presence of HIV-1 Nef in Jurkat cells stimulated with a combination of PMA and anti-CD28 upregulates the levels of PI3K production	PubMed
	nef	Downregulation of cell surface major histocompatibility complex class I (MHC-I) protein expression by HIV-1 Nef depends on a phosphoinositide 3-kinase (PI3K)-regulated signaling pathway, suggesting an interaction between Nef and PI3K	PubMed
	nef	The association of phosphatidylinositol (PI) 3-kinase with platelet-derived growth factor (PDGF) activated receptor was downregulated by HIV-1 nef expression	PubMed
	nef	HIV-1 Nef binds to the regulatory subunit (p85) of phosphatidylinositol-3-kinase (PI3K) in a manner that depends on the C-terminus of p85 and Nef	PubMed
Tat	tat	HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells	PubMed
	tat	HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells	PubMed
	tat	Arctigenin regulates the upstream PI3K enzyme from converting PIP2 to PIP3 in Tat-expressing CHME5 cells	PubMed
	tat	HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells	PubMed
	tat	Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation	PubMed
	tat	HIV-1 Tat-mediated cytopathic changes in human brain micro vascular endothelial cells involves its interaction with phosphatidylinositol 3-kinase (PI3K)	PubMed
	tat	Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway	PubMed
	tat	HIV-1 Tat activates phosphatidylinositol 3-kinase (PI3K), leading to the activation of Akt/PKB, decreased levels of cAMP and CREB phosphorylation, and the protection of cells from apoptosis	PubMed
	tat	Phosphatidylinositol 3-kinase inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter by affecting the formation of the Tat-associated kinase transactivating complex	PubMed
	tat	HIV-1 Tat induced release of MCP-1 from human lung microvascular endothelial cells involves an interaction between Tat and PI3 kinase	PubMed
	tat	Activation of protein kinase C-epsilon by HIV-1 Tat involves an interaction with PI 3-kinase	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH44517 (e-PCR)
- UniSTS:23069

WI-16112 (e-PCR)
- UniSTS:32034

RH17716 (e-PCR)
- UniSTS:69667

RH36897 (e-PCR)
- UniSTS:88871

PMC291832P1 (e-PCR)
- UniSTS:272438

PMC291832P2 (e-PCR)
- UniSTS:272439

RH123681 (e-PCR)
- UniSTS:135235

SGC31850 (e-PCR)
- UniSTS:83532

A003N10 (e-PCR)
- UniSTS:23654

SHGC-36976 (e-PCR)
- UniSTS:5993

RH94245 (e-PCR)
- UniSTS:88169

PIK3R1_8543 (e-PCR)
- UniSTS:467832

RH45585 (e-PCR)
- UniSTS:3991

RH75365 (e-PCR)
- UniSTS:84394

SHGC-107225 (e-PCR)
- UniSTS:183999

WI-12591 (e-PCR)
- UniSTS:68558

SHGC-36907 (e-PCR)
- UniSTS:23772

GDB:631841 (e-PCR)
- UniSTS:158435

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ErbB-3 class receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables insulin binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin receptor substrate binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activator activity	IEA Inferred from Electronic Annotation more info
enables neurotrophin TRKA receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol 3-kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol 3-kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol 3-kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol 3-kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol 3-kinase regulatory subunit binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphotyrosine residue binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane receptor protein tyrosine kinase adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in T follicular helper cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to UV	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytokine-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in growth hormone receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin-like growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in interleukin-18-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info
involved_in myeloid leukocyte migration	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol phosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of D-glucose import	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endoplasmic reticulum unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of focal adhesion disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cis-Golgi network	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of phosphatidylinositol 3-kinase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of phosphatidylinositol 3-kinase complex, class IA	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IA	IPI Inferred from Physical Interaction more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IA	ISS Inferred from Sequence or Structural Similarity more info
part_of phosphatidylinositol 3-kinase complex, class IA	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: phosphatidylinositol 3-kinase regulatory subunit alpha

Names: PI3 kinase-associated p85; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; growth factor receptor bound 1; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase-associated p-85 alpha; phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); ptdIns-3-kinase regulatory subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012849.2 RefSeqGene

Range

5001..91066

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_453

mRNA and Protein(s)

NM_001242466.2 → NP_001229395.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC016564, AF279367, AK094785, CA427864

Consensus CDS

CCDS56374.1

UniProtKB/TrEMBL

A0A8V8TLF7

Related

ENSP00000430098.1, ENST00000523872.1

Conserved Domains (4) summary

cd09930
Location:254 → 357

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd12924
Location:77 → 237

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

pfam16454
Location:76 → 235

PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

cl15255
Location:1 → 72

SH2; Src homology 2 (SH2) domain
NM_181504.4 → NP_852556.2 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2

See identical proteins and their annotated locations for NP_852556.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC016564, AK223613, CA427864, DA487709

Consensus CDS

CCDS3995.1

UniProtKB/TrEMBL

A0A8V8TME9

Related

ENSP00000338554.5, ENST00000336483.10

Conserved Domains (4) summary

cd09930
Location:347 → 450

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:55 → 165

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd12924
Location:170 → 330

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

pfam16454
Location:169 → 328

PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
NM_181523.3 → NP_852664.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1

See identical proteins and their annotated locations for NP_852664.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1) of this protein.

Source sequence(s)

AC016564, BC094795, CA427864, CT003423

Consensus CDS

CCDS3993.1

UniProtKB/Swiss-Prot

B3KT19, D3DWA0, E7EX19, P27986, Q15747, Q4VBZ7, Q53EM6, Q8IXA2, Q8N1C5

UniProtKB/TrEMBL

A0A2X0SFG1, A0A8V8TL10

Related

ENSP00000428056.1, ENST00000521381.6

Conserved Domains (5) summary

cd09930
Location:617 → 720

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:325 → 435

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd11910
Location:5 → 79

SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases

cd12924
Location:440 → 600

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

cd04388
Location:114 → 302

RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...
NM_181524.2 → NP_852665.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 3

See identical proteins and their annotated locations for NP_852665.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC016564, AF279367, CA427864

Consensus CDS

CCDS3994.1

UniProtKB/TrEMBL

B3KWZ7

Related

ENSP00000323512.8, ENST00000320694.13

Conserved Domains (3) summary

cd09930
Location:317 → 420

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:25 → 135

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd12924
Location:140 → 300

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

68215756..68301821

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005248542.4 → XP_005248599.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

See identical proteins and their annotated locations for XP_005248599.1

UniProtKB/Swiss-Prot

B3KT19, D3DWA0, E7EX19, P27986, Q15747, Q4VBZ7, Q53EM6, Q8IXA2, Q8N1C5

UniProtKB/TrEMBL

A0A2X0SFG1, A0A8V8TL10

Related

ENSP00000429277.1, ENST00000521657.6

Conserved Domains (5) summary

cd09930
Location:617 → 720

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:325 → 435

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd11910
Location:5 → 79

SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases

cd12924
Location:440 → 600

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

cd04388
Location:114 → 302

RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...
XM_017009585.3 → XP_016865074.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

UniProtKB/Swiss-Prot

B3KT19, D3DWA0, E7EX19, P27986, Q15747, Q4VBZ7, Q53EM6, Q8IXA2, Q8N1C5

UniProtKB/TrEMBL

A0A2X0SFG1, A0A8V8TL10

Related

ENSP00000513316.1, ENST00000697458.1

Conserved Domains (5) summary

cd09930
Location:617 → 720

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:325 → 435

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd11910
Location:5 → 79

SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases

cd12924
Location:440 → 600

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

cd04388
Location:114 → 302

RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...
XM_047417315.1 → XP_047273271.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

UniProtKB/Swiss-Prot

B3KT19, D3DWA0, E7EX19, P27986, Q15747, Q4VBZ7, Q53EM6, Q8IXA2, Q8N1C5

UniProtKB/TrEMBL

A0A2X0SFG1

Related

ENSP00000513333.1, ENST00000517643.2
XM_047417316.1 → XP_047273272.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2
XM_047417317.1 → XP_047273273.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

Related

ENSP00000513318.1, ENST00000697460.1

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

69037928..69124117

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054352826.1 → XP_054208801.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

UniProtKB/Swiss-Prot

B3KT19, D3DWA0, E7EX19, P27986, Q15747, Q4VBZ7, Q53EM6, Q8IXA2, Q8N1C5

UniProtKB/TrEMBL

A0A2X0SFG1
XM_054352828.1 → XP_054208803.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

UniProtKB/Swiss-Prot

B3KT19, D3DWA0, E7EX19, P27986, Q15747, Q4VBZ7, Q53EM6, Q8IXA2, Q8N1C5

UniProtKB/TrEMBL

A0A2X0SFG1
XM_054352827.1 → XP_054208802.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

UniProtKB/Swiss-Prot

B3KT19, D3DWA0, E7EX19, P27986, Q15747, Q4VBZ7, Q53EM6, Q8IXA2, Q8N1C5

UniProtKB/TrEMBL

A0A2X0SFG1
XM_054352829.1 → XP_054208804.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2