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    SIRPB2 signal regulatory protein beta 2 [ Homo sapiens (human) ]

    Gene ID: 284759, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SIRPB2provided by HGNC
    Official Full Name
    signal regulatory protein beta 2provided by HGNC
    Primary source
    HGNC:HGNC:16247
    See related
    Ensembl:ENSG00000196209 AllianceGenome:HGNC:16247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTPN1L; PTPNS1L3; dJ776F14.2
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in appendix (RPKM 5.0), placenta (RPKM 2.4) and 14 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SIRPB2 in Genome Data Viewer
    Location:
    20p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (1470685..1491420, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (1519882..1540613, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1455223..1472066, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372497 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:1396577-1397776 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:1408109-1408868 Neighboring gene NSFL1 cofactor Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:1446723-1447224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12593 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:1458844-1460043 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:1481226-1481777 Neighboring gene uncharacterized LOC105372499 Neighboring gene uncharacterized LOC105372498 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:1501740-1502939 Neighboring gene RNA, U6 small nuclear 917, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SIRPB1 promotes prostate cancer cell proliferation via Akt activation. Song Q, et al. Prostate, 2020 Mar. PMID 31905248, Free PMC Article
    2. Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation. Nyati MK, et al. Cancer Res, 2006 Dec 15. PMID 17178844
    3. The SIRP family of receptors and immune regulation. Barclay AN, et al. Nat Rev Immunol, 2006 Jun. PMID 16691243
    4. Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags. Chen J, et al. Proc Natl Acad Sci U S A, 2002 Sep 17. PMID 12213963, Free PMC Article
    5. A nomenclature for signal regulatory protein family members. van den Berg TK, et al. J Immunol, 2005 Dec 15. PMID 16339511

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    signal-regulatory protein beta-2
    Names
    SIRP-beta-2
    protein tyrosine phosphatase non-receptor type substrate protein
    protein tyrosine phosphatase, non-receptor type substrate 1-like 3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122962.2 → NP_001116434.1  signal-regulatory protein beta-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001116434.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK095499, AL109658, AY424277, BG539998, BM285394, DC313096, DC358609
      Consensus CDS
      CCDS42849.1
      UniProtKB/Swiss-Prot
      B4DLM9, E9PCW6, Q5JXA9, Q6TCH9
      UniProtKB/TrEMBL
      B3KTG0
      Related
      ENSP00000352849.3, ENST00000359801.8
      Conserved Domains (2) summary
      smart00410
      Location:46 → 149
      IG_like; Immunoglobulin like
      pfam07686
      Location:163 → 263
      V-set; Immunoglobulin V-set domain

    2. NM_001134836.2 → NP_001128308.1  signal-regulatory protein beta-2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to version 1, that results in a shorter protein (isoform 2) that lacks one of two immunoglobulin domains, when compared to isoform 1.
      Source sequence(s)
      AK095499, AK297072, AL109658
      Consensus CDS
      CCDS46570.1
      UniProtKB/Swiss-Prot
      Q5JXA9
      UniProtKB/TrEMBL
      B3KTG0
      Related
      ENSP00000402438.1, ENST00000444444.2
      Conserved Domains (2) summary
      smart00410
      Location:70 → 145
      IG_like; Immunoglobulin like
      pfam07686
      Location:65 → 165
      V-set; Immunoglobulin V-set domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      1470685..1491420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440129.1 → XP_047296085.1  signal-regulatory protein beta-2 isoform X4

      UniProtKB/TrEMBL
      F2Z2Y9
      Related
      ENSP00000435045.1, ENST00000486775.5

    2. XM_005260709.4 → XP_005260766.1  signal-regulatory protein beta-2 isoform X6

      UniProtKB/TrEMBL
      B7Z281
      Conserved Domains (2) summary
      smart00410
      Location:70 → 145
      IG_like; Immunoglobulin like
      pfam07686
      Location:65 → 165
      V-set; Immunoglobulin V-set domain

    3. XM_005260708.5 → XP_005260765.1  signal-regulatory protein beta-2 isoform X2

      UniProtKB/TrEMBL
      B3KTG0
      Conserved Domains (2) summary
      smart00410
      Location:46 → 149
      IG_like; Immunoglobulin like
      pfam07686
      Location:163 → 263
      V-set; Immunoglobulin V-set domain

    4. XM_047440130.1 → XP_047296086.1  signal-regulatory protein beta-2 isoform X5

    5. XM_047440127.1 → XP_047296083.1  signal-regulatory protein beta-2 isoform X1

    6. XM_047440128.1 → XP_047296084.1  signal-regulatory protein beta-2 isoform X3

    RNA

    1. XR_007067453.1 RNA Sequence

    2. XR_007067452.1 RNA Sequence

    3. XR_007067451.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      1519882..1540613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323392.1 → XP_054179367.1  signal-regulatory protein beta-2 isoform X4

    2. XM_054323394.1 → XP_054179369.1  signal-regulatory protein beta-2 isoform X6

    3. XM_054323390.1 → XP_054179365.1  signal-regulatory protein beta-2 isoform X2

    4. XM_054323393.1 → XP_054179368.1  signal-regulatory protein beta-2 isoform X5

    5. XM_054323389.1 → XP_054179364.1  signal-regulatory protein beta-2 isoform X1

    6. XM_054323391.1 → XP_054179366.1  signal-regulatory protein beta-2 isoform X3

    RNA

    1. XR_008485256.1 RNA Sequence

    2. XR_008485255.1 RNA Sequence

    3. XR_008485254.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_021484.1: Suppressed sequence

      Description
      NR_021484.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JXA9.1 GenPept UniProtKB/Swiss-Prot:Q5JXA9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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