KALRN kalirin RhoGEF kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: KALRNprovided by HGNC
Official Full Name: kalirin RhoGEF kinaseprovided by HGNC
Primary source: HGNC:HGNC:4814
See related: Ensembl:ENSG00000160145 MIM:604605; AllianceGenome:HGNC:4814
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DUO; CHD5; DUET; TRAD; CHDS5; HAPIP; KALNC2; ARHGEF24
Summary: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]
Expression: Broad expression in brain (RPKM 3.5), small intestine (RPKM 1.5) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q21.1-q21.2

Exon count:: 67

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (124033369..124726325)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (126759499..127452146)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (123752216..124445172)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma.
Title: Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma.
KALRN mutations promote antitumor immunity and immunotherapy response in cancer.
Title: KALRN mutations promote antitumor immunity and immunotherapy response in cancer.
Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.
Title: Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.
The interaction of kalirin with the C-terminal region of Htt influences the function of kalirin and modulates the cytotoxicity induced by C-terminal Htt.
Title: The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.
The data of this study reveal a novel mechanism for disease-associated single nucleotide variants of KALARN and provide a platform for modeling morphological changes in mental disorders.
Title: A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability.
SNPs of the KALRN gene are associated with intracranial atherosclerotic stenosis in the northern Chinese population.
Title: Genetic Variation of the Kalirin Gene is Associated with ICAS in the Chinese Population.
Combination of polymorphisms in the NOD2, IL17RA, EPHA2 and KALRN genes could play a significant role in the development of sarcoidosis by maintaining a chronic pro-inflammatory status in macrophages
Title: G908R NOD2 variant in a family with sarcoidosis.
The GG genotype and G allele of SNP rs7620580 were associated with a risk for ischemic stroke with an adjusted OR of 3.195 and an OR of 1.446, respectively. Haplotype analysis revealed that A-T-G,G-T-A, and A-T-A haplotypes were associated with ischemic stroke. Our results provide evidence that kalirin gene variations were associated with ischemic stroke in the Chinese Han population.
Title: Genetic Variant of Kalirin Gene Is Associated with Ischemic Stroke in a Chinese Han Population.
DNA sequencing provided evidence linking KALRN to monogenic intellectual disability in two patients.
Title: Exome sequencing discloses KALRN homozygous variant as likely cause of intellectual disability and short stature in a consanguineous pedigree.
Data suggest protein levels of kalirin and CHD7 in circulating extracellular vesicles (EVs) as endothelial dysfunction markers to monitor vascular condition in hypertensive patients with albuminuria.
Title: Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
New gene functions in megakaryopoiesis and platelet formation. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of kalirin, RhoGEF kinase (KALRN) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-147506 (e-PCR)
- UniSTS:172819

D3S4197 (e-PCR)
- UniSTS:55838

STS-R40615 (e-PCR)
- UniSTS:24369

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-79325 (e-PCR)
- UniSTS:103233

SHGC-151006 (e-PCR)
- UniSTS:173642

SHGC-77292 (e-PCR)
- UniSTS:20308

SHGC-143337 (e-PCR)
- UniSTS:171866

G16605 (e-PCR)
- UniSTS:71016

SHGC-77293 (e-PCR)
- UniSTS:77685

WIAF-2074 (e-PCR)
- UniSTS:32373

G63293 (e-PCR)
- UniSTS:140406

SHGC-146054 (e-PCR)
- UniSTS:174966

G31014 (e-PCR)
- UniSTS:9853

SHGC-67307 (e-PCR)
- UniSTS:89991

D3S1765 (e-PCR)
- UniSTS:63369

SHGC-106416 (e-PCR)
- UniSTS:169869

D3S1269 (e-PCR), detects polymorphism
- UniSTS:31657

SHGC-82179 (e-PCR)
- UniSTS:103085

D3S1269 (e-PCR), detects polymorphism
- UniSTS:33972

RH123675 (e-PCR)
- UniSTS:138685

D3S2460 (e-PCR)
- UniSTS:21182

G59872 (e-PCR)
- UniSTS:137155

SHGC-105715 (e-PCR)
- UniSTS:169414

D3S2322 (e-PCR), detects polymorphism
- UniSTS:42191

D3S3646 (e-PCR), detects polymorphism
- UniSTS:19415

D3S3384 (e-PCR)
- UniSTS:68824

RH104215 (e-PCR)
- UniSTS:98540

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	EXP Inferred from Experiment more info	PubMed
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	TAS Traceable Author Statement more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	TAS Traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in extrinsic component of membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kalirin

Names: huntingtin-associated protein interacting protein (duo); serine/threonine-protein kinase with Dbl- and pleckstrin homology domain

NP_001019831.2

EC 2.7.11.1

NP_001309917.1

EC 2.7.11.1

NP_001309918.1

EC 2.7.11.1

NP_001309919.1

EC 2.7.11.1

NP_001309920.1

EC 2.7.11.1

NP_001309921.1

EC 2.7.11.1

NP_001309922.1

EC 2.7.11.1

NP_001309923.1

EC 2.7.11.1

NP_001309924.1

EC 2.7.11.1

NP_001309925.1

EC 2.7.11.1

NP_001309926.1

EC 2.7.11.1

NP_001309927.1

EC 2.7.11.1

NP_001309928.1

EC 2.7.11.1

NP_001309929.1

EC 2.7.11.1

NP_001309930.1

EC 2.7.11.1

NP_001375341.1

EC 2.7.11.1

NP_001375342.1

EC 2.7.11.1

NP_001375343.1

EC 2.7.11.1

NP_001375344.1

EC 2.7.11.1

NP_001375345.1

EC 2.7.11.1

NP_001375346.1

EC 2.7.11.1

NP_001375347.1

EC 2.7.11.1

NP_001375348.1

EC 2.7.11.1

NP_003938.1

EC 2.7.11.1

NP_008995.2

EC 2.7.11.1

XP_006713873.1

EC 2.7.11.1

XP_006713874.1

EC 2.7.11.1

XP_006713875.1

EC 2.7.11.1

XP_006713876.1

EC 2.7.11.1

XP_006713877.1

EC 2.7.11.1

XP_011511581.1

EC 2.7.11.1

XP_011511582.1

EC 2.7.11.1

XP_011511583.1

EC 2.7.11.1

XP_011511585.1

EC 2.7.11.1

XP_016862918.1

EC 2.7.11.1

XP_016862919.1

EC 2.7.11.1

XP_016862923.1

EC 2.7.11.1

XP_016862924.1

EC 2.7.11.1

XP_024309579.1

EC 2.7.11.1

XP_047305113.1

EC 2.7.11.1

XP_047305114.1

EC 2.7.11.1

XP_047305115.1

EC 2.7.11.1

XP_047305116.1

EC 2.7.11.1

XP_047305117.1

EC 2.7.11.1

XP_047305118.1

EC 2.7.11.1

XP_047305119.1

EC 2.7.11.1

XP_047305120.1

EC 2.7.11.1

XP_047305121.1

EC 2.7.11.1

XP_054204269.1

EC 2.7.11.1

XP_054204270.1

EC 2.7.11.1

XP_054204271.1

EC 2.7.11.1

XP_054204272.1

EC 2.7.11.1

XP_054204273.1

EC 2.7.11.1

XP_054204274.1

EC 2.7.11.1

XP_054204275.1

EC 2.7.11.1

XP_054204276.1

EC 2.7.11.1

XP_054204277.1

EC 2.7.11.1

XP_054204278.1

EC 2.7.11.1

XP_054204279.1

EC 2.7.11.1

XP_054204280.1

EC 2.7.11.1

XP_054204281.1

EC 2.7.11.1

XP_054204282.1

EC 2.7.11.1

XP_054204283.1

EC 2.7.11.1

XP_054204284.1

EC 2.7.11.1

XP_054204285.1

EC 2.7.11.1

XP_054204286.1

EC 2.7.11.1

XP_054204287.1

EC 2.7.11.1

XP_054204288.1

EC 2.7.11.1

XP_054204289.1

EC 2.7.11.1

XP_054204290.1

EC 2.7.11.1

XP_054204291.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012742.3 RefSeqGene

Range

5002..697958

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001024660.5 → NP_001019831.2 kalirin isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). There are no publicly available transcripts representing the full-length splicing pattern of this variant; it is inferred from data in PMID:11891045 and from the rat homolog, NM_032062.1.

Source sequence(s)

AB011422, AC022336, AK125979, AK131379, AK314126, BM930007, BQ345377, DA756158, H11479, R45191, U94190

UniProtKB/Swiss-Prot

A8MSI4, C9JQ37, J3QSW6, O60229, Q6ZN45, Q8TBQ5, Q9NSZ4, Q9Y2A5

UniProtKB/TrEMBL

H7BXZ5

Related

ENSP00000353109.3, ENST00000360013.7

Conserved Domains (13) summary

smart00150
Location:1135 → 1235

SPEC; Spectrin repeats

cd11852
Location:1649 → 1708

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2325 → 2383

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:39 → 177

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2569 → 2660

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1284 → 1454

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:891 → 1129

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1461 → 1583

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2107 → 2241

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2690 → 2937

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1933 → 2102

RhoGEF; RhoGEF domain

pfam07679
Location:2471 → 2565

I-set; Immunoglobulin I-set domain

pfam16609
Location:1706 → 1923

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
NM_001322988.2 → NP_001309917.1 kalirin isoform 4

Status: REVIEWED

Source sequence(s)

AC069233, AC080008, AC112129, AC117401, AL137629

UniProtKB/TrEMBL

A0A1S5UZ29
NM_001322989.2 → NP_001309918.1 kalirin isoform 5

Status: REVIEWED

Source sequence(s)

AC069233, AC112129, AI024603, AK314126, U94190

Consensus CDS

CCDS82829.1

UniProtKB/TrEMBL

C9IZQ6

Related

ENSP00000418611.1, ENST00000460856.5

Conserved Domains (6) summary

smart00150
Location:1126 → 1226

SPEC; Spectrin repeats

smart00516
Location:39 → 177

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1275 → 1445

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:891 → 1120

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1452 → 1574

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

pfam00169
Location:1485 → 1570

PH; PH domain
NM_001322990.2 → NP_001309919.1 kalirin isoform 6

Status: REVIEWED

Source sequence(s)

AC069233, AC080008, AC112129, AC117401, AI024603
NM_001322991.2 → NP_001309920.1 kalirin isoform 7

Status: REVIEWED

Source sequence(s)

AC069233, AC080008, AC112129, AC117401, AI024603
NM_001322992.2 → NP_001309921.1 kalirin isoform 8

Status: REVIEWED

Source sequence(s)

AC069233, AC080008, AC112129, AC117401, AI024603

Consensus CDS

CCDS93360.1

UniProtKB/TrEMBL

A0A804HKT9

Related

ENSP00000508068.1, ENST00000684276.1
NM_001322993.2 → NP_001309922.1 kalirin isoform 9

Status: REVIEWED

Source sequence(s)

AC022336, AC080008, H11479
NM_001322994.2 → NP_001309923.1 kalirin isoform 10

Status: REVIEWED

Source sequence(s)

AC080008, AL137629

Consensus CDS

CCDS93363.1

UniProtKB/TrEMBL

A0A804HKJ7

Related

ENSP00000507954.1, ENST00000682363.1
NM_001322995.2 → NP_001309924.1 kalirin isoform 11

Status: REVIEWED

Source sequence(s)

AC080008, AL137629

UniProtKB/Swiss-Prot

O60229
NM_001322996.2 → NP_001309925.1 kalirin isoform 12

Status: REVIEWED

Source sequence(s)

AC080008, AL137629

UniProtKB/Swiss-Prot

O60229

Conserved Domains (5) summary

cd11853
Location:627 → 685

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

cd13241
Location:410 → 544

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00169
Location:443 → 529

PH; PH domain

pfam00621
Location:236 → 406

RhoGEF; RhoGEF domain

pfam16609
Location:25 → 235

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
NM_001322997.2 → NP_001309926.1 kalirin isoform 13

Status: REVIEWED

Source sequence(s)

AC080008, AL137629

UniProtKB/Swiss-Prot

O60229
NM_001322998.2 → NP_001309927.1 kalirin isoform 14

Status: REVIEWED

Source sequence(s)

AC080008, AL137629

UniProtKB/Swiss-Prot

O60229
NM_001322999.2 → NP_001309928.1 kalirin isoform 15

Status: REVIEWED

Description

Transcript Variant: Variants 16 and 17 encode isoforms that are the same length, but have distinct protein sequences.

Source sequence(s)

AC080008, AL137629

UniProtKB/Swiss-Prot

O60229
NM_001323000.2 → NP_001309929.1 kalirin isoform 16

Status: REVIEWED

Description

Transcript Variant: Variants 16 and 17 encode isoforms that are the same length, but have distinct protein sequences.

Source sequence(s)

AC080008, AL137629

UniProtKB/Swiss-Prot

O60229
NM_001323001.2 → NP_001309930.1 kalirin isoform 17

Status: REVIEWED

Source sequence(s)

AC080008, AL137629

UniProtKB/Swiss-Prot

O60229
NM_001388412.1 → NP_001375341.1 kalirin isoform 18

Status: REVIEWED

Source sequence(s)

AC069233, AC080008

Conserved Domains (10) summary

smart00150
Location:494 → 594

SPEC; Spectrin repeats

cd11852
Location:1008 → 1067

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:1683 → 1741

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

cd00160
Location:643 → 813

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:250 → 488

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:820 → 942

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:1466 → 1600

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:1292 → 1461

RhoGEF; RhoGEF domain

pfam16609
Location:1065 → 1291

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl02488
Location:5 → 249

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001388413.1 → NP_001375342.1 kalirin isoform 19

Status: REVIEWED

Source sequence(s)

AC069233, AC080008

Consensus CDS

CCDS93362.1

UniProtKB/TrEMBL

A0A804HI91, A0A804HJC5

Related

ENSP00000506956.1, ENST00000682695.1

Conserved Domains (5) summary

smart00150
Location:494 → 594

SPEC; Spectrin repeats

cd00160
Location:643 → 813

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:250 → 488

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:820 → 942

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cl02488
Location:5 → 249

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001388414.1 → NP_001375343.1 kalirin isoform 20

Status: REVIEWED

Source sequence(s)

AC069233, AC080008

UniProtKB/TrEMBL

A0A804HJC5

Related

ENSP00000507281.1, ENST00000683356.1
NM_001388415.1 → NP_001375344.1 kalirin isoform 21

Status: REVIEWED

Source sequence(s)

AC069233, AC080008

UniProtKB/TrEMBL

A0A804HJC5

Related

ENSP00000507171.1, ENST00000683146.1

Conserved Domains (5) summary

smart00150
Location:481 → 581

SPEC; Spectrin repeats

cd00160
Location:630 → 800

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:237 → 475

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:807 → 929

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cl02488
Location:5 → 236

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001388416.1 → NP_001375345.1 kalirin isoform 22

Status: REVIEWED

Source sequence(s)

AC069233, AC080008

Consensus CDS

CCDS93361.1

UniProtKB/TrEMBL

A0A804HIN3, A0A804HJC5

Related

ENSP00000507150.1, ENST00000684382.1

Conserved Domains (4) summary

smart00150
Location:472 → 572

SPEC; Spectrin repeats

cd00160
Location:621 → 791

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:237 → 466

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:798 → 920

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
NM_001388417.1 → NP_001375346.1 kalirin isoform 23

Status: REVIEWED

Source sequence(s)

AC069233, AC080008, AC112129, AC117381, AC117401

Conserved Domains (6) summary

smart00150
Location:1137 → 1237

SPEC; Spectrin repeats

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1286 → 1456

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:539 → 720

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1463 → 1585

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

TIGR02168
Location:745 → 1029

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
NM_001388418.1 → NP_001375347.1 kalirin isoform 24

Status: REVIEWED

Source sequence(s)

AC069233, AC080008, AC112129, AC117381, AC117401

Conserved Domains (5) summary

smart00150
Location:1128 → 1228

SPEC; Spectrin repeats

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1277 → 1447

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:893 → 1122

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1454 → 1576

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
NM_001388419.1 → NP_001375348.1 kalirin isoform 25

Status: REVIEWED

Source sequence(s)

AC022336, AC069233, AC080008, AC112129, AC117381, AC117401

Consensus CDS

CCDS93359.1

UniProtKB/TrEMBL

A0A804HLI0, H7BXZ5

Related

ENSP00000508359.1, ENST00000682506.1

Conserved Domains (14) summary

smart00150
Location:1137 → 1237

SPEC; Spectrin repeats

cd11852
Location:1651 → 1710

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2325 → 2383

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2569 → 2660

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1286 → 1456

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:893 → 1131

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1463 → 1585

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2108 → 2242

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2690 → 2937

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1934 → 2103

RhoGEF; RhoGEF domain

pfam07679
Location:2471 → 2565

I-set; Immunoglobulin I-set domain

pfam16609
Location:1708 → 1933

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2463 → 2466

Ig; Ig strand A [structural motif]
NM_003947.6 → NP_003938.1 kalirin isoform 2

See identical proteins and their annotated locations for NP_003938.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and lacks many exons in the 3' coding region, compared to variant 1. The encoded protein (isoform 2), also known as Trad and Duet, is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AI024603, AK131379, AK314126, BQ345377, U94190

Consensus CDS

CCDS3027.1

UniProtKB/Swiss-Prot

O60229

Related

ENSP00000240874.3, ENST00000240874.7

Conserved Domains (6) summary

smart00150
Location:1135 → 1235

SPEC; Spectrin repeats

smart00516
Location:39 → 177

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1284 → 1454

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:537 → 718

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1461 → 1583

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

TIGR02168
Location:743 → 1027

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
NM_007064.5 → NP_008995.2 kalirin isoform 3

See identical proteins and their annotated locations for NP_008995.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks many exons in the 5' coding region, compared to variant 1. The encoded protein (isoform 3), also known as Duo, is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AB011422, AC022336, AC080008, AK125979, BM930007, DA756158, DB450617, H11479, R45191

Consensus CDS

CCDS3028.1

UniProtKB/Swiss-Prot

O60229

Related

ENSP00000291478.4, ENST00000291478.9

Conserved Domains (9) summary

cd00096
Location:791 → 865

Ig; Immunoglobulin domain

cd11853
Location:628 → 686

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00220
Location:987 → 1241

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00063
Location:872 → 963

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:774 → 868

I-set; Immunoglobulin I-set domain

cd13241
Location:410 → 544

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:993 → 1240

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:236 → 406

RhoGEF; RhoGEF domain

pfam16609
Location:25 → 235

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

RNA

NR_028136.3 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) includes the same 5' exon but differs in the remaining exons, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK128223, AK311154, AK314126, BC037924

Related

ENST00000682890.1
NR_170952.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069233, AC080008
NR_170953.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069233, AC080008

Related

ENST00000682277.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

124033369..124726325

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006713810.4 → XP_006713873.1 kalirin isoform X1

UniProtKB/TrEMBL

H7BXZ5

Conserved Domains (16) summary

cd00096
Location:2490 → 2564

Ig; Immunoglobulin domain

cd11852
Location:1651 → 1710

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2327 → 2385

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00220
Location:2686 → 2940

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2571 → 2662

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1286 → 1456

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:893 → 1131

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2473 → 2567

I-set; Immunoglobulin I-set domain

cd13240
Location:1463 → 1585

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2109 → 2243

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2692 → 2939

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00169
Location:1496 → 1581

PH; PH domain

pfam00621
Location:1935 → 2105

RhoGEF; RhoGEF domain

pfam16609
Location:1708 → 1934

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl02488
Location:1101 → 1240

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_017007429.2 → XP_016862918.1 kalirin isoform X7

UniProtKB/TrEMBL

H7BXZ5
XM_011513279.3 → XP_011511581.1 kalirin isoform X2

UniProtKB/TrEMBL

H7BXZ5

Conserved Domains (16) summary

cd00096
Location:2489 → 2563

Ig; Immunoglobulin domain

cd11852
Location:1651 → 1710

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2326 → 2384

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00220
Location:2685 → 2939

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2570 → 2661

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1286 → 1456

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:893 → 1131

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2472 → 2566

I-set; Immunoglobulin I-set domain

cd13240
Location:1463 → 1585

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2109 → 2243

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2691 → 2938

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00169
Location:1496 → 1581

PH; PH domain

pfam00621
Location:1935 → 2105

RhoGEF; RhoGEF domain

pfam16609
Location:1708 → 1934

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl02488
Location:1101 → 1240

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_047449157.1 → XP_047305113.1 kalirin isoform X8
XM_006713814.4 → XP_006713877.1 kalirin isoform X10

UniProtKB/TrEMBL

H7BXZ5

Conserved Domains (16) summary

cd00096
Location:2458 → 2532

Ig; Immunoglobulin domain

cd11852
Location:1651 → 1710

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2295 → 2353

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00220
Location:2654 → 2908

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2539 → 2630

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1286 → 1456

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:893 → 1131

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2441 → 2535

I-set; Immunoglobulin I-set domain

cd13240
Location:1463 → 1585

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2077 → 2211

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2660 → 2907

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00169
Location:1496 → 1581

PH; PH domain

pfam00621
Location:1903 → 2073

RhoGEF; RhoGEF domain

pfam16609
Location:1708 → 1865

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl02488
Location:1101 → 1240

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_047449158.1 → XP_047305114.1 kalirin isoform X11
XM_011513280.3 → XP_011511582.1 kalirin isoform X3

UniProtKB/TrEMBL

H7BXZ5

Conserved Domains (16) summary

cd00096
Location:2489 → 2563

Ig; Immunoglobulin domain

cd11852
Location:1651 → 1710

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2326 → 2384

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00220
Location:2685 → 2939

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2570 → 2661

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1286 → 1456

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:893 → 1131

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2472 → 2566

I-set; Immunoglobulin I-set domain

cd13240
Location:1463 → 1585

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2108 → 2242

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2691 → 2938

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00169
Location:1496 → 1581

PH; PH domain

pfam00621
Location:1934 → 2104

RhoGEF; RhoGEF domain

pfam16609
Location:1708 → 1933

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl02488
Location:1101 → 1240

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_017007430.2 → XP_016862919.1 kalirin isoform X12

UniProtKB/TrEMBL

H7BXZ5
XM_006713811.4 → XP_006713874.1 kalirin isoform X4

UniProtKB/TrEMBL

H7BXZ5

Conserved Domains (16) summary

cd00096
Location:2481 → 2555

Ig; Immunoglobulin domain

cd11852
Location:1642 → 1701

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2318 → 2376

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00220
Location:2677 → 2931

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2562 → 2653

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1277 → 1447

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:893 → 1122

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2464 → 2558

I-set; Immunoglobulin I-set domain

cd13240
Location:1454 → 1576

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2100 → 2234

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2683 → 2930

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00169
Location:1487 → 1572

PH; PH domain

pfam00621
Location:1926 → 2096

RhoGEF; RhoGEF domain

pfam16609
Location:1699 → 1925

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl02488
Location:1124 → 1293

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006713812.4 → XP_006713875.1 kalirin isoform X6

UniProtKB/TrEMBL

H7BXZ5

Conserved Domains (16) summary

cd00096
Location:2477 → 2551

Ig; Immunoglobulin domain

cd11852
Location:1638 → 1697

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2314 → 2372

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00220
Location:2673 → 2927

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2558 → 2649

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1273 → 1443

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:539 → 755

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2460 → 2554

I-set; Immunoglobulin I-set domain

cd13240
Location:1450 → 1572

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2096 → 2230

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2679 → 2926

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00169
Location:1483 → 1568

PH; PH domain

pfam00621
Location:1922 → 2092

RhoGEF; RhoGEF domain

pfam16609
Location:1695 → 1921

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl02488
Location:1088 → 1227

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_047449159.1 → XP_047305115.1 kalirin isoform X13
XM_006713813.4 → XP_006713876.1 kalirin isoform X9

UniProtKB/TrEMBL

H7BXZ5

Conserved Domains (16) summary

cd00096
Location:2468 → 2542

Ig; Immunoglobulin domain

cd11852
Location:1629 → 1688

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2305 → 2363

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00220
Location:2664 → 2918

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2549 → 2640

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1264 → 1434

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:880 → 1109

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2451 → 2545

I-set; Immunoglobulin I-set domain

cd13240
Location:1441 → 1563

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2087 → 2221

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2670 → 2917

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00169
Location:1474 → 1559

PH; PH domain

pfam00621
Location:1913 → 2083

RhoGEF; RhoGEF domain

pfam16609
Location:1686 → 1912

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl02488
Location:1111 → 1280

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_011513283.3 → XP_011511585.1 kalirin isoform X16

UniProtKB/TrEMBL

A0A1S5UZ29

Conserved Domains (11) summary

cd11852
Location:1651 → 1710

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2327 → 2385

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1286 → 1456

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:539 → 720

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1463 → 1585

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2109 → 2243

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00169
Location:1496 → 1581

PH; PH domain

pfam00621
Location:1935 → 2105

RhoGEF; RhoGEF domain

pfam16609
Location:1708 → 1934

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl02488
Location:1101 → 1240

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_047449161.1 → XP_047305117.1 kalirin isoform X15
XM_047449160.1 → XP_047305116.1 kalirin isoform X14
XM_047449162.1 → XP_047305118.1 kalirin isoform X17
XM_024453811.2 → XP_024309579.1 kalirin isoform X18

UniProtKB/TrEMBL

A0A1S5UZ29

Related

ENST00000683592.1

Conserved Domains (10) summary

smart00150
Location:1128 → 1228

SPEC; Spectrin repeats

cd11852
Location:1642 → 1701

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2284 → 2342

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1277 → 1447

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:893 → 1122

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1454 → 1576

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2067 → 2201

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:1893 → 2062

RhoGEF; RhoGEF domain

pfam16609
Location:1699 → 1855

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_047449163.1 → XP_047305119.1 kalirin isoform X19
XM_017007434.3 → XP_016862923.1 kalirin isoform X21
XM_017007435.3 → XP_016862924.1 kalirin isoform X22
XM_047449165.1 → XP_047305121.1 kalirin isoform X23
XM_011513281.4 → XP_011511583.1 kalirin isoform X5

UniProtKB/TrEMBL

H7BXZ5

Related

ENSP00000346122.4, ENST00000354186.8

Conserved Domains (16) summary

cd00096
Location:2479 → 2553

Ig; Immunoglobulin domain

cd11852
Location:1640 → 1699

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2316 → 2374

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00220
Location:2675 → 2929

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00516
Location:39 → 177

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2560 → 2651

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1275 → 1445

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:891 → 1120

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2462 → 2556

I-set; Immunoglobulin I-set domain

cd13240
Location:1452 → 1574

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2098 → 2232

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2681 → 2928

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00169
Location:1485 → 1570

PH; PH domain

pfam00621
Location:1924 → 2094

RhoGEF; RhoGEF domain

pfam16609
Location:1697 → 1923

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl02488
Location:1122 → 1291

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_047449164.1 → XP_047305120.1 kalirin isoform X20