CYP2J2 cytochrome P450 family 2 subfamily J member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CYP2J2provided by HGNC
Official Full Name: cytochrome P450 family 2 subfamily J member 2provided by HGNC
Primary source: HGNC:HGNC:2634
See related: Ensembl:ENSG00000134716 MIM:601258; AllianceGenome:HGNC:2634
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CPJ2; CYPIIJ2
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
Expression: Biased expression in small intestine (RPKM 44.5), heart (RPKM 35.2) and 10 other tissues See more
Orthologs: all
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Genomic context

Location:: 1p32.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (59893308..59969212, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (59771763..59847665, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (60358980..60392445, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage.
Title: CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage.
Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.
Title: Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.
CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro.
Title: CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro.
CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma.
Title: CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma.
6,8-Diprenylorobol Induces Apoptosis in Human Hepatocellular Carcinoma Cells via Activation of FOXO3 and Inhibition of CYP2J2.
Title: 6,8-Diprenylorobol Induces Apoptosis in Human Hepatocellular Carcinoma Cells via Activation of FOXO3 and Inhibition of CYP2J2.
Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population.
Title: Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population.
Molecular determinant of substrate binding and specificity of cytochrome P450 2J2.
Title: Molecular determinant of substrate binding and specificity of cytochrome P450 2J2.
CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes.
Title: CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes.
In conclusion, the rs2280275 and rs11572325 SNPs of CYP2J2 may be considered novel genetic markers of hypertension, at least in Russian women
Title: A comprehensive study revealed SNP-SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk.
CYP2J2 50G>T (rs890293) polymorphism was associated with an increased risk for psoriasis in the Turkish population
Title: Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study.

Submit: New GeneRIF Correction See all GeneRIFs (106)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables arachidonic acid 11,12-epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonic acid 14,15-epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonic acid 5,6-epoxygenase activity	IEA Inferred from Electronic Annotation more info
enables arachidonic acid epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonic acid epoxygenase activity	TAS Traceable Author Statement more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydroperoxy icosatetraenoate isomerase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables linoleic acid epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	TAS Traceable Author Statement more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in epoxygenase P450 pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in epoxygenase P450 pathway	TAS Traceable Author Statement more info
involved_in fatty acid metabolic process	TAS Traceable Author Statement more info
involved_in icosanoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in linoleic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of heart contraction	TAS Traceable Author Statement more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 2J2

Names: albendazole monooxygenase (hydroxylating); albendazole monooxygenase (sulfoxide-forming); arachidonic acid epoxygenase; cytochrome P450, family 2, subfamily J, polypeptide 2; cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2; flavoprotein-linked monooxygenase; hydroperoxy icosatetraenoate isomerase; microsomal monooxygenase

NP_000766.2

EC 1.14.14.73

EC 1.14.14.74

EC 5.4.4.7

XP_047303454.1

EC 1.14.14.73

EC 1.14.14.74

EC 5.4.4.7

XP_047303455.1

EC 1.14.14.73

EC 1.14.14.74

EC 5.4.4.7

XP_054190678.1

EC 1.14.14.73

EC 1.14.14.74

EC 5.4.4.7

XP_054190679.1

EC 1.14.14.73

EC 1.14.14.74

EC 5.4.4.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007931.2 RefSeqGene

Range

47439..80904

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000775.4 → NP_000766.2 cytochrome P450 2J2

See identical proteins and their annotated locations for NP_000766.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the protein-coding transcript.

Source sequence(s)

BC032594

Consensus CDS

CCDS613.1

UniProtKB/Swiss-Prot

B2RD33, P51589, Q8TF13

Related

ENSP00000360247.3, ENST00000371204.4

Conserved Domains (1) summary

pfam00067
Location:44 → 497

p450; Cytochrome P450

RNA

NR_134981.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC032594, CD013972

Related

ENST00000466095.5
NR_134982.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC113175, BC032594, CD013973

Related

ENST00000468257.2