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    ACBD7 acyl-CoA binding domain containing 7 [ Homo sapiens (human) ]

    Gene ID: 414149, updated on 2-Nov-2024

    Summary

    Official Symbol
    ACBD7provided by HGNC
    Official Full Name
    acyl-CoA binding domain containing 7provided by HGNC
    Primary source
    HGNC:HGNC:17715
    See related
    Ensembl:ENSG00000176244 AllianceGenome:HGNC:17715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    bA455B2.2
    Summary
    Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 9.1), testis (RPKM 1.4) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See ACBD7 in Genome Data Viewer
    Location:
    10p13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (15075475..15088776, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (15089450..15102751, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (15117474..15130775, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ACBD7-DCLRE1CP1 readthrough Neighboring gene olfactory receptor family 7 subfamily E member 115 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3088 Neighboring gene DNA cross-link repair 1C pseudogene 1 Neighboring gene oleoyl-ACP hydrolase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3089 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:15089045-15089853 Neighboring gene MPRA-validated peak869 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:15125454-15125977 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:15125978-15126500 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2167 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:15138899-15139470 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 45 Neighboring gene RPP38 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ38219, FLJ52263, MGC33893

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    acyl-CoA-binding domain-containing protein 7
    Names
    acyl-Coenzyme A binding domain containing 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039844.3NP_001034933.1  acyl-CoA-binding domain-containing protein 7

      See identical proteins and their annotated locations for NP_001034933.1

      Status: VALIDATED

      Source sequence(s)
      AK095538, AL590365, BX114172
      Consensus CDS
      CCDS31153.1
      UniProtKB/Swiss-Prot
      A6NCI2, B3KTG8, Q8N6N7
      Related
      ENSP00000367453.4, ENST00000356189.6
      Conserved Domains (1) summary
      cl00221
      Location:387
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      15075475..15088776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      15089450..15102751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)