HRH2 histamine receptor H2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HRH2provided by HGNC
Official Full Name: histamine receptor H2provided by HGNC
Primary source: HGNC:HGNC:5183
See related: Ensembl:ENSG00000113749 MIM:142703; AllianceGenome:HGNC:5183
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: H2R; HH2R
Summary: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Expression: Broad expression in bone marrow (RPKM 7.6), heart (RPKM 5.0) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q35.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (175658071..175710756)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (176201850..176254534)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (175085074..175137759)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cryo-EM structure of cell-free synthesized human histamine 2 receptor/Gs complex in nanodisc environment.
Title: Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G(s) complex in nanodisc environment.
The mRNA expression and secretion of granzyme B are up-regulated via the histamine H2 receptor in human CD4[+] T cells.
Title: The mRNA expression and secretion of granzyme B are up-regulated via the histamine H2 receptor in human CD4(+) T cells.
Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells.
Title: Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells.
Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts.
Title: Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts.
Histamine H2 receptor stimulation upregulates TH2 chemokine CCL17 production in human M2a macrophages.
Title: Histamine H2 receptor stimulation upregulates T(H)2 chemokine CCL17 production in human M2a macrophages.
The presence of a minor allele at rs2241562 was associated with increased HF incidence in Chinese participants. Differences in myocardial HRH2 transcript abundance were seen in participants with dilated cardiomyopathy who responded to beta blockade compared to those who did not.
Title: Histamine H(2) Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial).
Pharmacological or genetic modulations of H2 and H4 HRs (H2R and H4R) not only suppressed gefitinib-induced cytostasis and differentiation of AML cells but also blocked EGFR and ERK1/2 inhibition in MDA-MB-231 cells
Title: Epidermal growth factor receptor inhibitor cancer drug gefitinib modulates cell growth and differentiation of acute myeloid leukemia cells via histamine receptors.
The T allele of rs3787429 exhibited protective effect against CHF under the dominant and additive models , while, for SNPs in HRH2, DAO, and HNMT, no significant associations were observed in the present study
Title: Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure.
High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the beta2-adrenergic receptor
Title: High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor.
Lack of Association between rs2067474 Polymorphism in Histamine Receptor H2 Gene and Breast Cancer in Chinese Han Population
Title: Lack of Association between rs2067474 Polymorphism in Histamine Receptor H2 Gene and Breast Cancer in Chinese Han Population.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

HRH2_1005 (e-PCR)
- UniSTS:277328

HRH2_V260 (e-PCR)
- UniSTS:277328

RH71388 (e-PCR)
- UniSTS:22639

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histamine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables histamine receptor activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in gastric acid secretion	IEA Inferred from Electronic Annotation more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histamine H2 receptor

Names: gastric receptor 1; gastric receptor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001131055.2 → NP_001124527.1 histamine H2 receptor isoform 1

See identical proteins and their annotated locations for NP_001124527.1

Status: REVIEWED

Source sequence(s)

BC054510, CF147823

Consensus CDS

CCDS47344.1

UniProtKB/TrEMBL

A0A1B0GVZ0

Related

ENSP00000366506.2, ENST00000377291.2

Conserved Domains (1) summary

cd15051
Location:19 → 299

7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001367711.1 → NP_001354640.1 histamine H2 receptor isoform 2

Status: REVIEWED

Source sequence(s)

AC010219

Consensus CDS

CCDS93828.1

UniProtKB/TrEMBL

A0A1B0GTK7, A0A1B0GVZ0

Related

ENSP00000489742.1, ENST00000636584.2

Conserved Domains (1) summary

cd15051
Location:19 → 299

7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001393460.1 → NP_001380389.1 histamine H2 receptor isoform 2

Status: REVIEWED

Source sequence(s)

AC010219

Consensus CDS

CCDS93828.1

UniProtKB/TrEMBL

A0A1B0GTK7, A0A1B0GVZ0

Conserved Domains (1) summary

cd15051
Location:19 → 299

7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001393461.1 → NP_001380390.1 histamine H2 receptor isoform 2

Status: REVIEWED

Source sequence(s)

AC010219

Consensus CDS

CCDS93828.1

UniProtKB/TrEMBL

A0A1B0GTK7, A0A1B0GVZ0

Conserved Domains (1) summary

cd15051
Location:19 → 299

7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

NR_160284.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC010219

Related

ENST00000624694.2
NR_171689.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC010219

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

175658071..175710756

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011534549.4 → XP_011532851.1 histamine H2 receptor isoform X1

See identical proteins and their annotated locations for XP_011532851.1

UniProtKB/TrEMBL

A0A1B0GTK7, A0A1B0GVZ0

Conserved Domains (1) summary

cd15051
Location:19 → 299

7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006714865.4 → XP_006714928.1 histamine H2 receptor isoform X2

UniProtKB/TrEMBL

A0A1B0GVZ0

Conserved Domains (1) summary

pfam00001
Location:35 → 288

7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

176201850..176254534

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054352491.1 → XP_054208466.1 histamine H2 receptor isoform X1

UniProtKB/TrEMBL

A0A1B0GTK7
XM_054352492.1 → XP_054208467.1 histamine H2 receptor isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_022304.2: Suppressed sequence

Description

NM_022304.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.