Usp46 ubiquitin specific peptidase 46 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Usp46provided by RGD
Official Full Name: ubiquitin specific peptidase 46provided by RGD
Primary source: RGD:1564808
See related: EnsemblRapid:ENSRNOG00000002106 AllianceGenome:RGD:1564808
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564808
Summary: Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Involved in regulation of postsynaptic neurotransmitter receptor internalization. Is active in glutamatergic synapse. Orthologous to human USP46 (ubiquitin specific peptidase 46). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 200.5), Lung (RPKM 118.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (34504074..34573318)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (34150055..34219227)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (36687134..36755360)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP46-mediated regulation of Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor ubiquitination and turnover may play an important role in synaptic plasticity and brain function.
Title: The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking.
results suggest that the Lys 92 deletion of USP46 could influence enzyme activity and thereby provide a molecular clue how the enzyme regulating the pathogenesis of mental illnesses.
Title: Lysine 92 amino acid residue of USP46, a gene associated with 'behavioral despair' in mice, influences the deubiquitinating enzyme activity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI009635 (e-PCR)
- UniSTS:249916

RH143580 (e-PCR)
- UniSTS:232826

RH130614 (e-PCR)
- UniSTS:213898

BE102309 (e-PCR)
- UniSTS:244132

RH139292 (e-PCR)
- UniSTS:221378

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adult feeding behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in behavioral fear response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to ethanol	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavioral response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in righting reflex	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within righting reflex	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 46

Names: deubiquitinating enzyme 46; ubiquitin specific protease 46; ubiquitin thioesterase 46; ubiquitin-specific-processing protease 46

NP_001178525.1

EC 3.4.19.12

XP_006250951.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191596.1 → NP_001178525.1 ubiquitin carboxyl-terminal hydrolase 46

See identical proteins and their annotated locations for NP_001178525.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

F1M625, G8ACC6

UniProtKB/TrEMBL

A6JD26

Related

ENSRNOP00000002879.7, ENSRNOT00000002879.9

Conserved Domains (1) summary

cd02663
Location:36 → 363

Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

34504074..34573318

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250889.5 → XP_006250951.1 ubiquitin carboxyl-terminal hydrolase 46 isoform X1

UniProtKB/TrEMBL

A0A0G2K2V1, A0A8I5ZTT8

Related

ENSRNOP00000080787.1, ENSRNOT00000097061.2

Conserved Domains (2) summary

cd02663
Location:29 → 356

Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:27 → 355

UCH; Ubiquitin carboxyl-terminal hydrolase