ZW10 zw10 kinetochore protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZW10provided by HGNC
Official Full Name: zw10 kinetochore proteinprovided by HGNC
Primary source: HGNC:HGNC:13194
See related: Ensembl:ENSG00000086827 MIM:603954; AllianceGenome:HGNC:13194
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HZW10; KNTC1AP
Summary: This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
Expression: Ubiquitous expression in testis (RPKM 9.8), skin (RPKM 6.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q23.2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (113733187..113773692, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (113743514..113784012, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (113603909..113644414, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The RZZ complex was purified to homogeneity and subjected to systemic crystallization.
Title: Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complex.
hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain
Title: hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain.
Results together suggest that NAG links between p31 and ZW10-RINT-1 and is involved in Golgi-to-ER transport.
Title: Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport.
The interaction between ZW10 and dynamitin showed that the N-terminal region of ZW10 is the major binding site for dynamitin and, like full-length ZW10, could move along microtubules to the centrosomal area in a dynein-dynactin-dependent manner.
Title: N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function.
Accumulation of ZW10 at tensionless kinetochores stems from a 4-fold reduction of kinetochore turnover rate and requires aurora B kinase activity.
Title: Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores.
Stable hZW10 kinetochore residency at prometaphase kinetochores is dependent on its interaction with hZwint-1, and is essential for mitotic checkpoint arrest.
Title: Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.
RNAi-mediated depletion of ZW10 markedly-reduced congression efficiency.
Title: Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment.
Rab6 regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT-1 and COG.
Title: Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.
show that ZW10 interacting protein-1(Zwint-1) is required and is sufficient for kinetochore localization of Zeste White 10 (ZW10) in HeLa cells
Title: Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling.
targeting of ZW10 to the perinuclear Golgi region was found to depend on the perinuclear accumulation of dynactin
Title: Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH12322 (e-PCR)
- UniSTS:17986

WI-14184 (e-PCR)
- UniSTS:80090

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables centromeric DNA binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in mitotic metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of attachment of spindle microtubules to kinetochore	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of exit from mitosis	IDA Inferred from Direct Assay more info	PubMed
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of Dsl1/NZR complex	IDA Inferred from Direct Assay more info	PubMed
part_of Dsl1/NZR complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RZZ complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RZZ complex	IDA Inferred from Direct Assay more info	PubMed
part_of RZZ complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore microtubule	NAS Non-traceable Author Statement more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: centromere/kinetochore protein zw10 homolog

Names: ZW10 homolog, centromere/kinetochore protein; ZW10, kinetochore associated, homolog; zeste white 10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004724.4 → NP_004715.1 centromere/kinetochore protein zw10 homolog

See identical proteins and their annotated locations for NP_004715.1

Status: REVIEWED

Source sequence(s)

BC128264, BM833775, BQ773926, DB506745, U54996

Consensus CDS

CCDS8363.1

UniProtKB/Swiss-Prot

A1A528, O43264

UniProtKB/TrEMBL

B2R7C2

Related

ENSP00000200135.3, ENST00000200135.8

Conserved Domains (2) summary

pfam06248
Location:9 → 621

Zw10; Centromere/kinetochore Zw10

cl21453
Location:598 → 768

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

113733187..113773692 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017018558.3 → XP_016874047.1 centromere/kinetochore protein zw10 homolog isoform X1

UniProtKB/TrEMBL

B2R7C2

Conserved Domains (2) summary

pfam06248
Location:9 → 557

Zw10; Centromere/kinetochore Zw10

cl21453
Location:534 → 704

PKc_like; Protein Kinases, catalytic domain