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    COX6B2 cytochrome c oxidase subunit 6B2 [ Homo sapiens (human) ]

    Gene ID: 125965, updated on 23-Mar-2024

    Summary

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    Official Symbol
    COX6B2provided by HGNC
    Official Full Name
    cytochrome c oxidase subunit 6B2provided by HGNC
    Primary source
    HGNC:HGNC:24380
    See related
    Ensembl:ENSG00000160471 MIM:618127; AllianceGenome:HGNC:24380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT59; COXVIB2
    Summary
    Predicted to be involved in oxidative phosphorylation. Located in mitochondrial crista. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 26.9) See more
    Orthologs
    mouse all
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    Genomic context

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    See COX6B2 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55349704..55354719, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58445210..58450225, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55861072..55866087, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene BR serine/threonine kinase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55824387-55824912 Neighboring gene transmembrane protein 150B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55849388-55850162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55850163-55850936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55855204-55856008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55856009-55856814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55858005-55858699 Neighboring gene lysine methyltransferase 5C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11024 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55871113-55871613 Neighboring gene golgi associated RAB2 interactor family member 5B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55874435-55875039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55880086-55880927 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55881771-55882611 Neighboring gene interleukin 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma. Cheng CC, et al. Elife, 2020 Sep 29. PMID 32990599, Free PMC Article
    2. Isolation of cDNAs encoding subunit VIb of cytochrome c oxidase and steady-state levels of coxVIb mRNA in different tissues. Taanman JW, et al. Gene, 1990 Sep 14. PMID 2172092
    3. Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb--the counterpart to testes-specific cytochrome c? Hüttemann M, et al. Mol Reprod Dev, 2003 Sep. PMID 12874793
    4. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. König R, et al. Cell, 2008 Oct 3. PMID 18854154, Free PMC Article
    5. Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors. Feng X, et al. Sci Adv, 2022 May 13. PMID 35559673, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [High expression of COX6B2 in gastric cancer is associated with poor long-term prognosis and promotes cell proliferation and cell cycle progression by inhibiting p53 signaling].
      Title: [High expression of COX6B2 in gastric cancer is associated with poor long-term prognosis and promotes cell proliferation and cell cycle progression by inhibiting p53 signaling].
    2. Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma.
      Title: Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of cytochrome c oxidase subunit VIb polypeptide 2 (COX6B2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ46422, MGC119094

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oxidative phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial crista IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial crista IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 6B2
    Names
    COX VIb-2
    cancer/testis antigen 59
    cytochrome c oxidase subunit VIb polypeptide 2 (testis)
    cytochrome c oxidase subunit VIb, testes-specific

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369798.1 → NP_001356727.1  cytochrome c oxidase subunit 6B2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AC020922, AK057427
      Consensus CDS
      CCDS42630.1
      UniProtKB/Swiss-Prot
      Q6YFQ2, Q7L1R4, Q96DL5
      Related
      ENSP00000467266.1, ENST00000593184.5
      Conserved Domains (1) summary
      cd00926
      Location:10 → 87
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    2. NM_001369799.1 → NP_001356728.1  cytochrome c oxidase subunit 6B2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC020922
      Consensus CDS
      CCDS42630.1
      UniProtKB/Swiss-Prot
      Q6YFQ2, Q7L1R4, Q96DL5
      Conserved Domains (1) summary
      cd00926
      Location:10 → 87
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    3. NM_001369800.1 → NP_001356729.1  cytochrome c oxidase subunit 6B2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC020922
      Consensus CDS
      CCDS42630.1
      UniProtKB/Swiss-Prot
      Q6YFQ2, Q7L1R4, Q96DL5
      Conserved Domains (1) summary
      cd00926
      Location:10 → 87
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    4. NM_144613.5 → NP_653214.2  cytochrome c oxidase subunit 6B2

      See identical proteins and their annotated locations for NP_653214.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      BC026123, BG717038
      Consensus CDS
      CCDS42630.1
      UniProtKB/Swiss-Prot
      Q6YFQ2, Q7L1R4, Q96DL5
      Related
      ENSP00000320672.3, ENST00000326529.9
      Conserved Domains (1) summary
      cd00926
      Location:10 → 87
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      55349704..55354719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      58445210..58450225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6YFQ2.1 GenPept UniProtKB/Swiss-Prot:Q6YFQ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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