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    LCMT1 leucine carboxyl methyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 51451, updated on 2-Nov-2024

    Summary

    Official Symbol
    LCMT1provided by HGNC
    Official Full Name
    leucine carboxyl methyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:17557
    See related
    Ensembl:ENSG00000205629 MIM:610286; AllianceGenome:HGNC:17557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LCMT; PPMT1; CGI-68
    Summary
    LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in testis (RPKM 19.0), brain (RPKM 15.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LCMT1 in Genome Data Viewer
    Location:
    16p12.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (25111742..25178228)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (25391240..25457759)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (25123063..25189549)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 11 pseudogene Neighboring gene LCMT1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:25117841-25118342 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:25118343-25118842 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:25122486-25123013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10605 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:25137470-25137712 Neighboring gene LCMT1 antisense RNA 2 Neighboring gene RNA, 7SL, cytoplasmic 557, pseudogene Neighboring gene aquaporin 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    leucine carboxyl methyltransferase 1
    Names
    [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
    protein phosphatase methyltransferase 1
    protein-leucine O-methyltransferase
    NP_001027563.1
    NP_057393.2
    XP_005255411.1
    XP_011544164.1
    XP_011544166.1
    XP_047290153.1
    XP_054236414.1
    XP_054236415.1
    XP_054236416.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032391.2NP_001027563.1  leucine carboxyl methyltransferase 1 isoform b

      See identical proteins and their annotated locations for NP_001027563.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate internal exons that encode an in-frame segment, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
      Source sequence(s)
      AL560574, BC001214, BI459868
      Consensus CDS
      CCDS45446.1
      UniProtKB/Swiss-Prot
      Q9UIC8
      Related
      ENSP00000370353.4, ENST00000380966.8
      Conserved Domains (1) summary
      pfam04072
      Location:26162
      LCM; Leucine carboxyl methyltransferase
    2. NM_016309.3NP_057393.2  leucine carboxyl methyltransferase 1 isoform a

      See identical proteins and their annotated locations for NP_057393.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC001214, BI459868
      Consensus CDS
      CCDS45445.1
      UniProtKB/Swiss-Prot
      A6NL89, A8K770, Q53FC5, Q96CI5, Q9H6I9, Q9NTG4, Q9UIC8, Q9Y378
      Related
      ENSP00000382021.3, ENST00000399069.8
      Conserved Domains (1) summary
      pfam04072
      Location:26217
      LCM; Leucine carboxyl methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      25111742..25178228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545864.2XP_011544166.1  leucine carboxyl methyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_011544166.1

      UniProtKB/Swiss-Prot
      Q9UIC8
      Conserved Domains (1) summary
      pfam04072
      Location:67240
      LCM; Leucine carboxyl methyltransferase
    2. XM_011545862.3XP_011544164.1  leucine carboxyl methyltransferase 1 isoform X3

      Conserved Domains (1) summary
      pfam04072
      Location:67185
      LCM; Leucine carboxyl methyltransferase
    3. XM_047434197.1XP_047290153.1  leucine carboxyl methyltransferase 1 isoform X2

    4. XM_005255354.5XP_005255411.1  leucine carboxyl methyltransferase 1 isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:1117
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      25391240..25457759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380441.1XP_054236416.1  leucine carboxyl methyltransferase 1 isoform X4

    2. XM_054380439.1XP_054236414.1  leucine carboxyl methyltransferase 1 isoform X1

    3. XM_054380440.1XP_054236415.1  leucine carboxyl methyltransferase 1 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016015.3: Suppressed sequence

      Description
      NM_016015.3: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.