ARPC3 actin related protein 2/3 complex subunit 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARPC3provided by HGNC
Official Full Name: actin related protein 2/3 complex subunit 3provided by HGNC
Primary source: HGNC:HGNC:706
See related: Ensembl:ENSG00000111229 MIM:604225; AllianceGenome:HGNC:706
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARC21; p21-Arc
Summary: This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Expression: Ubiquitous expression in lymph node (RPKM 232.8), bone marrow (RPKM 231.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (110434823..110450337, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (110412518..110428033, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (110872628..110888142, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cancer cell motility mediated by the actin-related protein 2/3 complex (Arp2/3) is required for vessel co-option in liver metastases in vivo.
Title: Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases.
genetic association study in population in Canada: Data suggest that an SNP in the promoter region of ARPC3 (CpG-SNP rs3759384 C>T) is associated with metabolic syndrome complicated by severe abdominal obesity and hypertriglyceridemia in the population studied.
Title: A CpG-SNP Located within the ARPC3 Gene Promoter Is Associated with Hypertriglyceridemia in Severely Obese Patients.
Endogenous Nogo-B, which may exert its effects through ARPC 2/3 and MYL-9, is necessary for the migration and contraction of airway smooth muscle cells.
Title: Nogo-B regulates migration and contraction of airway smooth muscle cells by decreasing ARPC 2/3 and increasing MYL-9 expression.
The actin-related protein 3 structures were more visible with anti-p34Arc monoclonal antibody.
Title: Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH98959 (e-PCR)
- UniSTS:90704

RH48745 (e-PCR)
- UniSTS:59058

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in actin polymerization-dependent cell motility	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	IDA Inferred from Direct Assay more info	PubMed
located_in actin cytoskeleton	TAS Traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
part_of filamentous actin	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	HDA more info	PubMed
located_in growth cone leading edge	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: actin-related protein 2/3 complex subunit 3

Names: ARP2/3 protein complex subunit p21; actin related protein 2/3 complex, subunit 3, 21kDa; arp2/3 complex 21 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278556.2 → NP_001265485.1 actin-related protein 2/3 complex subunit 3 isoform 1

See identical proteins and their annotated locations for NP_001265485.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1)

Source sequence(s)

AC144548, AI144468, BC067747, BF434378

Consensus CDS

CCDS9146.1

UniProtKB/Swiss-Prot

O00554, O15145

UniProtKB/TrEMBL

B2R4D5, Q2LE71

Related

ENSP00000228825.7, ENST00000228825.12

Conserved Domains (1) summary

pfam04062
Location:1 → 173

P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit
NM_001287222.2 → NP_001274151.1 actin-related protein 2/3 complex subunit 3 isoform 2

See identical proteins and their annotated locations for NP_001274151.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the 3' coding region compared to variant 1. The resulting shorter isoform (2) lacks 1 aa compared to isoform 1.

Source sequence(s)

AC144548, AI144468, BC078162, BF434378, BG620669

UniProtKB/TrEMBL

B2R4D5, Q2LE71

Conserved Domains (1) summary

pfam04062
Location:1 → 172

P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit