ARRB1 arrestin beta 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARRB1provided by HGNC
Official Full Name: arrestin beta 1provided by HGNC
Primary source: HGNC:HGNC:711
See related: Ensembl:ENSG00000137486 MIM:107940; AllianceGenome:HGNC:711
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARB1; ARR1
Summary: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
Expression: Broad expression in brain (RPKM 24.0), lung (RPKM 19.9) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.4

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (75260122..75351661, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (75189729..75281255, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (74971166..75062705, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles of the gate loop in beta-arrestin-1 conformational dynamics and phosphorylated receptor interaction.
Title: Roles of the gate loop in β-arrestin-1 conformational dynamics and phosphorylated receptor interaction.
The beta-arrestin1/endothelin axis bolsters ovarian fibroblast-dependent invadosome activity and cancer cell metastatic potential.
Title: The β-arrestin1/endothelin axis bolsters ovarian fibroblast-dependent invadosome activity and cancer cell metastatic potential.
The NPXXY Motif Regulates beta-Arrestin Recruitment by the CB1 Cannabinoid Receptor.
Title: The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid Receptor.
Testosterone and Prolactin Perturbations Possibly Associated with Reduced Levels of beta-Arrestin1 in Mononuclear Leukocytes of Women with Premenstrual Dysphoric Disorder.
Title: Testosterone and Prolactin Perturbations Possibly Associated with Reduced Levels of β-Arrestin1 in Mononuclear Leukocytes of Women with Premenstrual Dysphoric Disorder.
The interaction of beta-arrestin1 with talin1 driven by endothelin A receptor as a feature of alpha5beta1 integrin activation in high-grade serous ovarian cancer.
Title: The interaction of β-arrestin1 with talin1 driven by endothelin A receptor as a feature of α5β1 integrin activation in high-grade serous ovarian cancer.
Cannabinoid 1 (CB1) receptor arrestin subtype-selectivity and phosphorylation dependence.
Title: Cannabinoid 1 (CB(1) ) receptor arrestin subtype-selectivity and phosphorylation dependence.
Tobacco use is associated with low peripheral beta-arrestin 1 levels in major depression: A preliminary report.
Title: Tobacco use is associated with low peripheral beta-arrestin 1 levels in major depression: A preliminary report.
Dual roles of beta-arrestin 1 in mediating cell metabolism and proliferation in gastric cancer.
Title: Dual roles of β-arrestin 1 in mediating cell metabolism and proliferation in gastric cancer.
betaArrestin1 regulates glucocorticoid receptor mitogenic signaling in castration-resistant prostate cancer.
Title: βArrestin1 regulates glucocorticoid receptor mitogenic signaling in castration-resistant prostate cancer.
beta-Arrestin 1 and 2 similarly influence mu-opioid receptor mobility and distinctly modulate adenylyl cyclase activity.
Title: β-Arrestin 1 and 2 similarly influence μ-opioid receptor mobility and distinctly modulate adenylyl cyclase activity.

Submit: New GeneRIF Correction See all GeneRIFs (187)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Overexpression of HIV-1 Tat results in a nonspecific activation of the expression of beta-arrestin	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S1007 (e-PCR)
- UniSTS:92417

STS-M78804 (e-PCR)
- UniSTS:11013

WI-21016 (e-PCR)
- UniSTS:68132

D8S2279 (e-PCR)
- UniSTS:473907

WI-20596 (e-PCR)
- UniSTS:13414

WI-15243 (e-PCR)
- UniSTS:19841

L17877 (e-PCR)
- UniSTS:61334

D11S4555 (e-PCR)
- UniSTS:28841

WI-16137 (e-PCR)
- UniSTS:49577

G31124 (e-PCR)
- UniSTS:13259

D17S1790 (e-PCR)
- UniSTS:73954

G32376 (e-PCR)
- UniSTS:116965

A009B14 (e-PCR)
- UniSTS:13309

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables angiotensin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables arrestin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme inhibitor activity	TAS Traceable Author Statement more info	PubMed
NOT enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables insulin-like growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-8 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual perception	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	TAS Traceable Author Statement more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in lysosomal membrane	TAS Traceable Author Statement more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in pseudopodium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-arrestin-1

Names: arrestin 2; non-visual arrestin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028118.1 RefSeqGene

Range

5171..96710

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004041.5 → NP_004032.2 beta-arrestin-1 isoform A

See identical proteins and their annotated locations for NP_004032.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript variant and encodes the longer isoform (A).

Source sequence(s)

AK293758, AL157484, AP001972, BC003636, BM681392, DA358665

Consensus CDS

CCDS44684.1

UniProtKB/Swiss-Prot

B6V9G8, O75625, O75630, P49407, Q2PP20, Q9BTK8

UniProtKB/TrEMBL

A8K103

Related

ENSP00000409581.2, ENST00000420843.7

Conserved Domains (2) summary

smart01017
Location:193 → 356

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:18 → 174

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
NM_020251.4 → NP_064647.1 beta-arrestin-1 isoform B

See identical proteins and their annotated locations for NP_064647.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform B) compared to isoform A.

Source sequence(s)

AF084940, AK293758, AL157484, AP001972, BC003636, BM681392, DA358665

Consensus CDS

CCDS31640.1

UniProtKB/TrEMBL

A8K103

Related

ENSP00000353124.3, ENST00000360025.7

Conserved Domains (2) summary

smart01017
Location:193 → 348

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:18 → 174

Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

75260122..75351661 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017017754.3 → XP_016873243.1 beta-arrestin-1 isoform X7

UniProtKB/TrEMBL

A8K103
XM_017017752.3 → XP_016873241.1 beta-arrestin-1 isoform X4

UniProtKB/TrEMBL

A8K103
XM_011545035.2 → XP_011543337.1 beta-arrestin-1 isoform X5

UniProtKB/TrEMBL

A8K103

Conserved Domains (2) summary

smart01017
Location:224 → 379

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:49 → 205

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_017017751.1 → XP_016873240.1 beta-arrestin-1 isoform X2

UniProtKB/TrEMBL

A8K103
XM_011545034.2 → XP_011543336.1 beta-arrestin-1 isoform X3

UniProtKB/TrEMBL

A8K103

Conserved Domains (2) summary

smart01017
Location:224 → 387

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:49 → 205

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_017017750.1 → XP_016873239.1 beta-arrestin-1 isoform X1

UniProtKB/TrEMBL

A8K103
XM_017017753.1 → XP_016873242.1 beta-arrestin-1 isoform X6

UniProtKB/TrEMBL

A8K103