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    SERBP1 SERPINE1 mRNA binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 26135, updated on 28-Oct-2024

    Summary

    Official Symbol
    SERBP1provided by HGNC
    Official Full Name
    SERPINE1 mRNA binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:17860
    See related
    Ensembl:ENSG00000142864 MIM:607378; AllianceGenome:HGNC:17860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-55; CHD3IP; HABP4L; Hero45; PAIRBP1; PAI-RBP1
    Summary
    Enables several functions, including SUMO binding activity; mRNA 3'-UTR binding activity; and ribosome binding activity. Involved in PML body organization and ribosome hibernation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in esophagus (RPKM 40.3), thyroid (RPKM 34.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SERBP1 in Genome Data Viewer
    Location:
    1p31.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (67407810..67430402, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (67285390..67307973, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (67873493..67896085, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DNAJB6 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 979 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 980 Neighboring gene NANOG hESC enhancer GRCh37_chr1:67784539-67785040 Neighboring gene interleukin 12 receptor subunit beta 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1175 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1177 Neighboring gene RNA, U6 small nuclear 387, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:67894622-67895258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1180 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:67895894-67896529 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:67924294-67925217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:67926895-67927395 Neighboring gene MPRA-validated peak278 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr1:67943422-67943604 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:67945137-67945276 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:67965969-67966472 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:67980737-67981378 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:67981379-67982018 Neighboring gene long intergenic non-protein coding RNA 1702 Neighboring gene Sharpr-MPRA regulatory region 10397 Neighboring gene Sharpr-MPRA regulatory region 12925 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:68005018-68005200 Neighboring gene RNA, U6 small nuclear 1031, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90489, DKFZp564M2423

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding EXP
    Inferred from Experiment
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables SUMO binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation elongation factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation repressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in PML body organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mRNA stability NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in ribosome hibernation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    SERPINE1 mRNA-binding protein 1
    Names
    PAI-1 mRNA binding protein
    PAI1 RNA-binding protein 1
    chromodomain helicase DNA binding protein 3 interacting protein
    plasminogen activator inhibitor 1 RNA-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018067.2NP_001018077.1  SERPINE1 mRNA-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001018077.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK074970, AL358512, AL590559, BC008045
      Consensus CDS
      CCDS30746.1
      UniProtKB/Swiss-Prot
      Q5VU19, Q5VU20, Q5VU22, Q8NC51, Q8WUH0, Q96SE2, Q9BTY3, Q9BUM4, Q9Y367, Q9Y4S3
      UniProtKB/TrEMBL
      Q63HR1
      Related
      ENSP00000360034.2, ENST00000370995.6
      Conserved Domains (2) summary
      pfam04774
      Location:189313
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5152
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
    2. NM_001018068.2NP_001018078.1  SERPINE1 mRNA-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001018078.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AL358512, AL590559, BC020555
      Consensus CDS
      CCDS30748.1
      UniProtKB/TrEMBL
      Q63HR1
      Related
      ENSP00000360029.5, ENST00000370990.5
      Conserved Domains (2) summary
      pfam04774
      Location:189307
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5152
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
    3. NM_001018069.2NP_001018079.1  SERPINE1 mRNA-binding protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001018079.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate, in-frame splice site in the coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AF151813, AL358512, AL590559
      Consensus CDS
      CCDS30747.1
      UniProtKB/TrEMBL
      Q63HR1
      Related
      ENSP00000354591.6, ENST00000361219.11
      Conserved Domains (2) summary
      pfam04774
      Location:189298
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5152
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
    4. NM_015640.4NP_056455.3  SERPINE1 mRNA-binding protein 1 isoform 4

      See identical proteins and their annotated locations for NP_056455.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses alternate, in-frame splice sites in the coding region, compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.
      Source sequence(s)
      AK074970, AL358512, BI464676, BX647139
      Consensus CDS
      CCDS639.1
      UniProtKB/TrEMBL
      Q5VU21, Q63HR1
      Related
      ENSP00000360033.4, ENST00000370994.8
      Conserved Domains (2) summary
      pfam04774
      Location:189292
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5152
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      67407810..67430402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      67285390..67307973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)