U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CAPN7 calpain 7 [ Homo sapiens (human) ]

    Gene ID: 23473, updated on 28-Oct-2024

    Summary

    Official Symbol
    CAPN7provided by HGNC
    Official Full Name
    calpain 7provided by HGNC
    Primary source
    HGNC:HGNC:1484
    See related
    Ensembl:ENSG00000131375 MIM:606400; AllianceGenome:HGNC:1484
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PALBH; CALPAIN7
    Summary
    Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 16.5), ovary (RPKM 11.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CAPN7 in Genome Data Viewer
    Location:
    3p25.1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (15206246..15252916)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (15208655..15255322)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (15247753..15294423)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RPS3A pseudogene 53 Neighboring gene MPRA-validated peak4546 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:15198577-15199776 Neighboring gene collagen type VI alpha 4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14101 Neighboring gene SH3BP5 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:15309450-15309989 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:15309990-15310528 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:15310708-15311907 Neighboring gene SH3 domain binding protein 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:15329844-15330019 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ36423

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MIT domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of epithelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in self proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    calpain-7
    Names
    calpain like protease
    homolog of Aspergillus Nidulans PALB
    palB homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376086.1NP_001363015.1  calpain-7 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC087590
      UniProtKB/TrEMBL
      B2RAM2
      Conserved Domains (3) summary
      smart00720
      Location:643766
      calpain_III; calpain_III domain
      cd00044
      Location:170494
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cl00299
      Location:41115
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    2. NM_001376087.1NP_001363016.1  calpain-7 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC087590
      UniProtKB/TrEMBL
      B2RAM2, Q7Z479
      Conserved Domains (4) summary
      smart00720
      Location:620743
      calpain_III; calpain_III domain
      cd00044
      Location:147471
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd02681
      Location:576
      MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
      cl00299
      Location:85149
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    3. NM_001376089.1NP_001363018.1  calpain-7 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC087590
      UniProtKB/TrEMBL
      B2RAM2
      Conserved Domains (4) summary
      smart00720
      Location:593716
      calpain_III; calpain_III domain
      cd00044
      Location:214538
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd02681
      Location:576
      MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
      cl00299
      Location:85159
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    4. NM_001376090.1NP_001363019.1  calpain-7 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC087590
      UniProtKB/TrEMBL
      B2RAM2
      Conserved Domains (4) summary
      smart00720
      Location:574695
      calpain_III; calpain_III domain
      cd00044
      Location:214538
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd02681
      Location:576
      MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
      cl00299
      Location:85159
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    5. NM_001376091.1NP_001363020.1  calpain-7 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC087590
      UniProtKB/TrEMBL
      B2RAM2
      Conserved Domains (3) summary
      smart00720
      Location:549672
      calpain_III; calpain_III domain
      cd00044
      Location:170494
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cl00299
      Location:41115
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    6. NM_001376093.1NP_001363022.1  calpain-7 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC087590
      Conserved Domains (4) summary
      smart00720
      Location:502625
      calpain_III; calpain_III domain
      cd00044
      Location:123447
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd02681
      Location:576
      MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
      cl00299
      Location:85125
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    7. NM_014296.3NP_055111.1  calpain-7 isoform 1

      See identical proteins and their annotated locations for NP_055111.1

      Status: REVIEWED

      Source sequence(s)
      AB028639, BC056202, BI464220, BM974327, BX502535
      Consensus CDS
      CCDS2624.1
      UniProtKB/Swiss-Prot
      Q9Y6W3
      UniProtKB/TrEMBL
      B2RAM2
      Related
      ENSP00000253693.2, ENST00000253693.7
      Conserved Domains (4) summary
      smart00720
      Location:687810
      calpain_III; calpain_III domain
      cd00044
      Location:214538
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd02681
      Location:576
      MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
      cl00299
      Location:85159
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

    RNA

    1. NR_164761.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087590
    2. NR_164762.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087590
    3. NR_164763.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087590
    4. NR_164764.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087590
    5. NR_164765.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087590
    6. NR_164766.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087590
    7. NR_164767.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087590

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      15206246..15252916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447831.1XP_047303787.1  calpain-7 isoform X1

    2. XM_047447832.1XP_047303788.1  calpain-7 isoform X2

    3. XM_047447833.1XP_047303789.1  calpain-7 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      15208655..15255322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345907.1XP_054201882.1  calpain-7 isoform X1

    2. XM_054345908.1XP_054201883.1  calpain-7 isoform X2

    3. XM_054345909.1XP_054201884.1  calpain-7 isoform X3