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    ZNF655 zinc finger protein 655 [ Homo sapiens (human) ]

    Gene ID: 79027, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ZNF655provided by HGNC
    Official Full Name
    zinc finger protein 655provided by HGNC
    Primary source
    HGNC:HGNC:30899
    See related
    Ensembl:ENSG00000197343 MIM:617891; AllianceGenome:HGNC:30899
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VIK; VIK-1
    Summary
    This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in skin (RPKM 10.9), lymph node (RPKM 10.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Try the new Transcript table

    Genomic context

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    See ZNF655 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99558642..99576453)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (100797976..100815787)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99156265..99174076)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 3 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26324 Neighboring gene uncharacterized LOC105375422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26326 Neighboring gene family with sequence similarity 200 member A Neighboring gene transmembrane protein 225B Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:99213715-99214694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99227460-99228106 Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99236540-99236705 Neighboring gene ARF GTPase 6 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF655 is involved in development and progression of non-small-cell lung cancer. Teng Z, et al. Life Sci, 2021 Sep 1. PMID 34144060
    2. USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle. Song N, et al. Mol Carcinog, 2023 Oct. PMID 37314216
    3. ZNF655 promotes the progression of hepatocellular carcinoma through PSMB8. Fan S, et al. Cell Biol Int, 2023 Sep. PMID 37272200
    4. Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. Houlard M, et al. Oncogene, 2005 Jan 6. PMID 15558030
    5. Sequence diversity and haplotype structure at the human CYP3A cluster. Thompson EE, et al. Pharmacogenomics J, 2006 Mar-Apr. PMID 16314882

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF655 promotes the progression of hepatocellular carcinoma through PSMB8.
      Title: ZNF655 promotes the progression of hepatocellular carcinoma through PSMB8.
    2. ZNF655 is involved in development and progression of non-small-cell lung cancer.
      Title: ZNF655 is involved in development and progression of non-small-cell lung cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC5521, FLJ23461, MGC10859, MGC16203, DKFZp686M1631

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 655
    Names
    vav-1 interacting Kruppel-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029962.1 RefSeqGene

      Range
      5221..23032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001009958.1 → NP_001009958.1  zinc finger protein 655 isoform c

      See identical proteins and their annotated locations for NP_001009958.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has a distinct 5' UTR and an alternate 3' exon, compared to variant 7. Both variants 4 and 9 encode the same isoform (c), which has a shorter and distinct C-terminus compared to isoform f.
      Source sequence(s)
      AK027114, BC063478, BE293580
      Consensus CDS
      CCDS34695.1
      UniProtKB/TrEMBL
      C9J9R2
      Related
      ENSP00000396396.1, ENST00000440391.5

    2. NM_001009960.1 → NP_001009960.1  zinc finger protein 655 isoform a

      See identical proteins and their annotated locations for NP_001009960.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has a distinct 5' UTR and lacks an alternate in-frame exon, compared to variant 7. Both variants 1 and 3 encode the same isoform (a), which is shorter than isoform f.
      Source sequence(s)
      AY099353, BC024770, BC037407, BE293580, CR749270
      Consensus CDS
      CCDS5669.1
      UniProtKB/Swiss-Prot
      A4D291, A6NGD3, B4E3M4, B7Z9Q9, D6W5T4, Q8IV00, Q8N720, Q8TA89, Q96EZ3, Q9BQ85
      Related
      ENSP00000377718.2, ENST00000394163.2
      Conserved Domains (3) summary
      COG5048
      Location:185 → 290
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:332 → 352
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:394 → 419
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001083956.2 → NP_001077425.1  zinc finger protein 655 isoform f

      See identical proteins and their annotated locations for NP_001077425.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) represents the longest transcript. Variants 7 and 8 encode the longest isoform (f).
      Source sequence(s)
      AK128057, BC024770, BC063478, CR749270, DN993232
      Consensus CDS
      CCDS47655.1
      UniProtKB/Swiss-Prot
      Q8N720
      UniProtKB/TrEMBL
      Q68DU4
      Related
      ENSP00000419135.1, ENST00000493277.5
      Conserved Domains (3) summary
      COG5048
      Location:220 → 325
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:367 → 387
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:429 → 454
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001085366.2 → NP_001078835.1  zinc finger protein 655 isoform c

      See identical proteins and their annotated locations for NP_001078835.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) has an alternate 3' coding exon, compared to variant 7. Both variants 4 and 9 encode the same isoform (c), which has a shorter and distinct C-terminus compared to isoform f.
      Source sequence(s)
      BC000823, BM829333
      Consensus CDS
      CCDS34695.1
      UniProtKB/TrEMBL
      C9J9R2
      Related
      ENSP00000350530.2, ENST00000357864.6

    5. NM_001085367.1 → NP_001078836.1  zinc finger protein 655 isoform b

      See identical proteins and their annotated locations for NP_001078836.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) has a distinct 5' UTR and includes alternate exons in the 3' coding region and 3' UTR, compared to variant 7. Both variants 2 and 10 encode the same isoform (b), which has a shorter and distinct C-terminus compared to isoform f.
      Source sequence(s)
      BC000823, BE293580, BI912391
      Consensus CDS
      CCDS5670.1
      UniProtKB/Swiss-Prot
      Q8N720
      Conserved Domains (2) summary
      smart00349
      Location:77 → 123
      KRAB; krueppel associated box
      pfam01352
      Location:77 → 116
      KRAB; KRAB box

    6. NM_001085368.1 → NP_001078837.1  zinc finger protein 655 isoform f

      See identical proteins and their annotated locations for NP_001078837.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 7. Variants 7 and 8 encode the longest isoform (f).
      Source sequence(s)
      AK128057, BC024770, BE293580, BI548533, CR749270
      Consensus CDS
      CCDS47655.1
      UniProtKB/Swiss-Prot
      Q8N720
      UniProtKB/TrEMBL
      Q68DU4
      Related
      ENSP00000393876.1, ENST00000424881.5
      Conserved Domains (3) summary
      COG5048
      Location:220 → 325
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:367 → 387
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:429 → 454
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001363332.1 → NP_001350261.1  zinc finger protein 655 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC005020, AK128057, BC024770, BI548533, CR749270, DC418016
      Consensus CDS
      CCDS47655.1
      Conserved Domains (3) summary
      COG5048
      Location:220 → 325
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:367 → 387
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:429 → 454
      zf-H2C2_2; Zinc-finger double domain

    8. NM_001363333.1 → NP_001350262.1  zinc finger protein 655 isoform f

      Status: REVIEWED

      Source sequence(s)
      AK128057, BC024770, BI548533, CR749270, DA314253
      Consensus CDS
      CCDS47655.1
      Conserved Domains (3) summary
      COG5048
      Location:220 → 325
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:367 → 387
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:429 → 454
      zf-H2C2_2; Zinc-finger double domain

    9. NM_001363334.1 → NP_001350263.1  zinc finger protein 655 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC005020, AK128057, BC024770, BI548533, CR749270, CV030898, DC418016
      Consensus CDS
      CCDS5669.1
      UniProtKB/Swiss-Prot
      A4D291, A6NGD3, B4E3M4, B7Z9Q9, D6W5T4, Q8IV00, Q8N720, Q8TA89, Q96EZ3, Q9BQ85
      Conserved Domains (3) summary
      COG5048
      Location:185 → 290
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:332 → 352
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:394 → 419
      zf-H2C2_2; Zinc-finger double domain

    10. NM_024061.4 → NP_076966.1  zinc finger protein 655 isoform b

      See identical proteins and their annotated locations for NP_076966.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes alternate exons in the 3' coding region and 3' UTR, compared to variant 7. Both variants 2 and 10 encode the same isoform (b), which has a shorter and distinct C-terminus compared to isoform f.
      Source sequence(s)
      BC000823, BC063478
      Consensus CDS
      CCDS5670.1
      UniProtKB/Swiss-Prot
      Q8N720
      Related
      ENSP00000322363.5, ENST00000320583.9
      Conserved Domains (2) summary
      smart00349
      Location:77 → 123
      KRAB; krueppel associated box
      pfam01352
      Location:77 → 116
      KRAB; KRAB box

    11. NM_138494.3 → NP_612503.1  zinc finger protein 655 isoform a

      See identical proteins and their annotated locations for NP_612503.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 7. Both variants 1 and 3 encode the same isoform (a), which is shorter than isoform f.
      Source sequence(s)
      AK128057, BC024770, BC037407, BC063478, CR749270
      Consensus CDS
      CCDS5669.1
      UniProtKB/Swiss-Prot
      A4D291, A6NGD3, B4E3M4, B7Z9Q9, D6W5T4, Q8IV00, Q8N720, Q8TA89, Q96EZ3, Q9BQ85
      Related
      ENSP00000252713.4, ENST00000252713.9
      Conserved Domains (3) summary
      COG5048
      Location:185 → 290
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:332 → 352
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:394 → 419
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      99558642..99576453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420832.1 → XP_047276788.1  zinc finger protein 655 isoform X4

    2. XM_047420831.1 → XP_047276787.1  zinc finger protein 655 isoform X4

    3. XM_047420828.1 → XP_047276784.1  zinc finger protein 655 isoform X1

    4. XM_047420829.1 → XP_047276785.1  zinc finger protein 655 isoform X2

    5. XM_047420830.1 → XP_047276786.1  zinc finger protein 655 isoform X3

      UniProtKB/TrEMBL
      Q68DU4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      100797976..100815787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358994.1 → XP_054214969.1  zinc finger protein 655 isoform X4

    2. XM_054358993.1 → XP_054214968.1  zinc finger protein 655 isoform X4

    3. XM_054358990.1 → XP_054214965.1  zinc finger protein 655 isoform X1

    4. XM_054358991.1 → XP_054214966.1  zinc finger protein 655 isoform X2

    5. XM_054358992.1 → XP_054214967.1  zinc finger protein 655 isoform X3

      UniProtKB/TrEMBL
      Q68DU4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001009956.1: Suppressed sequence

      Description
      NM_001009956.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_001009957.1: Suppressed sequence

      Description
      NM_001009957.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N720.3 GenPept UniProtKB/Swiss-Prot:Q8N720

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