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    CTNNAL1 catenin alpha like 1 [ Homo sapiens (human) ]

    Gene ID: 8727, updated on 28-Oct-2024

    Summary

    Official Symbol
    CTNNAL1provided by HGNC
    Official Full Name
    catenin alpha like 1provided by HGNC
    Primary source
    HGNC:HGNC:2512
    See related
    Ensembl:ENSG00000119326 MIM:604785; AllianceGenome:HGNC:2512
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACRP; CLLP; alpha-CATU
    Summary
    Predicted to enable actin filament binding activity and cadherin binding activity. Acts upstream of or within Rho protein signal transduction. Located in cytosol. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in adrenal (RPKM 101.6), ovary (RPKM 57.7) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CTNNAL1 in Genome Data Viewer
    Location:
    9q31.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (108942577..109013499, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (121111650..121182574, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (111704857..111775779, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene actin like 7A Neighboring gene elongator acetyltransferase complex subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20160 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:111713956-111715155 Neighboring gene actin binding transcription modulator Neighboring gene uncharacterized LOC105376216 Neighboring gene RNA, 5.8S ribosomal pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:111774967-111775470 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:111798078-111799277 Neighboring gene transmembrane protein 245 Neighboring gene microRNA 32 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20164 Neighboring gene ferric chelate reductase 1 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ08121

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    alpha-catulin
    Names
    alpha-catenin-related protein
    alpha2-catulin
    catenin (cadherin-associated protein), alpha-like 1
    catenin alpha-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286974.2NP_001273903.1  alpha-catulin isoform b

      See identical proteins and their annotated locations for NP_001273903.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, which results in an alternate 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AF135021, AI148526, AK022926
      Consensus CDS
      CCDS69638.1
      UniProtKB/TrEMBL
      B3KMX6
      Related
      ENSP00000363723.4, ENST00000374595.8
      Conserved Domains (1) summary
      pfam01044
      Location:92675
      Vinculin; Vinculin family
    2. NM_003798.4NP_003789.1  alpha-catulin isoform a

      See identical proteins and their annotated locations for NP_003789.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
      Source sequence(s)
      AF030233, AK022926
      Consensus CDS
      CCDS6775.1
      UniProtKB/Swiss-Prot
      B5BU47, O76084, Q53FQ2, Q5JTQ7, Q5JTQ8, Q9UBT7, Q9Y401
      UniProtKB/TrEMBL
      B3KMX6
      Related
      ENSP00000320434.4, ENST00000325551.9
      Conserved Domains (1) summary
      pfam01044
      Location:92675
      Vinculin; Vinculin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      108942577..109013499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015250.3XP_016870739.1  alpha-catulin isoform X2

    2. XM_005252291.5XP_005252348.1  alpha-catulin isoform X1

      UniProtKB/TrEMBL
      B3KMX6
      Conserved Domains (1) summary
      pfam01044
      Location:92675
      Vinculin; Vinculin family

    RNA

    1. XR_007061368.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      121111650..121182574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364092.1XP_054220067.1  alpha-catulin isoform X1

    2. XM_054364093.1XP_054220068.1  alpha-catulin isoform X2

    RNA

    1. XR_008488100.1 RNA Sequence