IL36A interleukin 36 alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL36Aprovided by HGNC
Official Full Name: interleukin 36 alphaprovided by HGNC
Primary source: HGNC:HGNC:15562
See related: Ensembl:ENSG00000136694 MIM:605509; AllianceGenome:HGNC:15562
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON)
Summary: The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]
Expression: Restricted expression toward esophagus (RPKM 90.8) See more
Orthologs: all
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Genomic context

Location:: 2q14.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (113005459..113011072)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (113431988..113437599)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (113763036..113765621)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases.
Title: Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases.
Altered Gene Expression of IL-35 and IL-36alpha in the Skin of Patients with Atopic Dermatitis.
Title: Altered Gene Expression of IL-35 and IL-36α in the Skin of Patients with Atopic Dermatitis.
The Emerging Roles of IL-36, IL-37, and IL-38 in Diabetes Mellitus and its Complications.
Title: The Emerging Roles of IL-36, IL-37, and IL-38 in Diabetes Mellitus and its Complications.
IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic.
Title: IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic.
IL-36 is Closely Related to Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease.
Title: IL-36 is Closely Related to Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease.
Interleukin-36alpha is elevated in diffuse systemic sclerosis and may potentiate fibrosis.
Title: Interleukin-36α is elevated in diffuse systemic sclerosis and may potentiate fibrosis.
IL-36alpha and IL-36gamma expressions in the differential diagnosis of palmoplantar psoriasis and palmoplantar eczema: A retrospective histopathologic and immunohistochemical study.
Title: IL-36α and IL-36γ expressions in the differential diagnosis of palmoplantar psoriasis and palmoplantar eczema: A retrospective histopathologic and immunohistochemical study.
Interleukin-36alpha inhibits colorectal cancer metastasis by enhancing the infiltration and activity of CD8(+) T lymphocytes.
Title: Interleukin-36α inhibits colorectal cancer metastasis by enhancing the infiltration and activity of CD8(+) T lymphocytes.
Interleukin-36alpha suppresses growth of non-small cell lung cancer in vitro by reducing angiogenesis.
Title: Interleukin-36α suppresses growth of non-small cell lung cancer in vitro by reducing angiogenesis.
Decreased serum profile of the interleukin-36alpha in polycystic ovary syndrome.
Title: Decreased serum profile of the interleukin-36α in polycystic ovary syndrome.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-1 receptor binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in inflammatory response to antigenic stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-36 alpha

Names: FIL1 epsilon; IL-1 epsilon; IL-1F6 (FIL-1-epsilon); interleukin 1 family, member 6 (epsilon); interleukin-1 epsilon; interleukin-1 family member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014440.3 → NP_055255.1 interleukin-36 alpha

See identical proteins and their annotated locations for NP_055255.1

Status: REVIEWED

Source sequence(s)

AC016724, AF201831, AK314149

Consensus CDS

CCDS42734.1

UniProtKB/Swiss-Prot

B2RAD9, Q53SR7, Q5BLR4, Q7RTZ8, Q9UHA7

Related

ENSP00000259211.6, ENST00000259211.7

Conserved Domains (1) summary

cl00094
Location:15 → 152

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

113005459..113011072

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011510965.2 → XP_011509267.1 interleukin-36 alpha isoform X1

See identical proteins and their annotated locations for XP_011509267.1

UniProtKB/Swiss-Prot

B2RAD9, Q53SR7, Q5BLR4, Q7RTZ8, Q9UHA7

Conserved Domains (1) summary

cl00094
Location:15 → 152

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
XM_005263639.3 → XP_005263696.1 interleukin-36 alpha isoform X1

See identical proteins and their annotated locations for XP_005263696.1

UniProtKB/Swiss-Prot

B2RAD9, Q53SR7, Q5BLR4, Q7RTZ8, Q9UHA7

Conserved Domains (1) summary

cl00094
Location:15 → 152

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
XM_017003806.2 → XP_016859295.1 interleukin-36 alpha isoform X1

UniProtKB/Swiss-Prot

B2RAD9, Q53SR7, Q5BLR4, Q7RTZ8, Q9UHA7

Conserved Domains (1) summary

cl00094
Location:15 → 152

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).