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    HPA2 histone acetyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856323, updated on 29-Jun-2024

    Summary

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    Gene symbol
    HPA2
    Gene description
    histone acetyltransferase
    Primary source
    FungiDB:YPR193C
    Locus tag
    YPR193C
    See related
    SGD:S000006397; AllianceGenome:SGD:S000006397; VEuPathDB:YPR193C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KAT10
    Summary
    Enables N-acetyltransferase activity. Involved in protein acetylation. Located in cytoplasm. Orthologous to several human genes including SAT2 (spermidine/spermine N1-acetyltransferase family member 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See HPA2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (922909..923379, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ubiquinol--cytochrome-c reductase subunit 2 Neighboring gene Aqy1p Neighboring gene Opt2p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. D-amino acid N-acetyltransferase of Saccharomyces cerevisiae: a close homologue of histone acetyltransferase Hpa2p acting exclusively on free D-amino acids. Yow GY, et al. Arch Microbiol, 2004 Nov. PMID 15375647
    2. Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily. Angus-Hill ML, et al. J Mol Biol, 1999 Dec 17. PMID 10600387
    3. Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast. Islam A, et al. Cell Div, 2011 Jun 8. PMID 21651791, Free PMC Article
    4. Genome-wide relationships between TAF1 and histone acetyltransferases in Saccharomyces cerevisiae. Durant M, et al. Mol Cell Biol, 2006 Apr. PMID 16537921, Free PMC Article
    5. Common industrial sake yeast strains have three copies of the AQY1-ARR3 region of chromosome XVI in their genomes. Ogihara F, et al. Yeast, 2008 Jun. PMID 18509847

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    histone acetyltransferase
    NP_015519.1
    • Tetrameric histone acetyltransferase; has similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity; also acetylates polyamines

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      922909..923379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184290.1 → NP_015519.1  TPA: histone acetyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015519.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4J3, Q06592
      UniProtKB/TrEMBL
      A0A8H4BWF1, A6ZX67, B3LKF1, C7GP74, C8ZJM2, G2WQ04, N1NVM7
      Conserved Domains (1) summary
      pfam00583
      Location:22 → 144
      Acetyltransf_1; Acetyltransferase (GNAT) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06592.1

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