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    GPD2 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854095, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPD2
    Official Full Name
    glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2
    Primary source
    SGD:S000005420
    Locus tag
    YOL059W
    See related
    AllianceGenome:SGD:S000005420; FungiDB:YOL059W; VEuPathDB:YOL059W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GPD3
    Summary
    Enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity. Involved in NADH oxidation and glycerol metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1) and GPD1L (glycerol-3-phosphate dehydrogenase 1 like). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See GPD2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (217126..218448)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ribose phosphate diphosphokinase subunit PRS5 Neighboring gene Mam3p Neighboring gene argininosuccinate synthase Neighboring gene dipeptidyl-peptidase III

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Improving ethanol productivity by modification of glycolytic redox factor generation in glycerol-3-phosphate dehydrogenase mutants of an industrial ethanol yeast. Guo ZP, et al. J Ind Microbiol Biotechnol, 2011 Aug. PMID 20824484
    2. Elimination of glycerol production in anaerobic cultures of a Saccharomyces cerevisiae strain engineered to use acetic acid as an electron acceptor. Guadalupe Medina V, et al. Appl Environ Microbiol, 2010 Jan. PMID 19915031, Free PMC Article
    3. Enhanced glycerol production in Shochu yeast by heat-shock treatment is due to prolonged transcription of GPD1. Kajiwara Y, et al. J Biosci Bioeng, 2000. PMID 16232830
    4. Over-expressing GLT1 in a gpd2Delta mutant of Saccharomyces cerevisiae to improve ethanol production. Kong QX, et al. Appl Microbiol Biotechnol, 2007 Jul. PMID 17505823
    5. Cloning and characterization of a NAD+-dependent glycerol-3-phosphate dehydrogenase gene from Candida glycerinogenes, an industrial glycerol producer. Chen X, et al. FEMS Yeast Res, 2008 Aug. PMID 18452539

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of Gpd1 and Gpd2 by distinct kinases enables rapid adaptation to specific stress conditions in Saccharomyces cerevisiae.
      Title: Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADH oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADH oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NADH oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol-3-phosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2
    NP_014582.1
    • NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog, GPD1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      217126..218448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183314.1 → NP_014582.1  TPA: glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014582.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W208, P41911, P50905
      UniProtKB/TrEMBL
      A6ZNF1, B3LJ00, C7GK26, N1NVP2
      Conserved Domains (1) summary
      TIGR03376
      Location:85 → 432
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41911.2

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