SPE2 adenosylmethionine decarboxylase SPE2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SPE2
Official Full Name: adenosylmethionine decarboxylase SPE2
Primary source: SGD:S000005412
Locus tag: YOL052C
See related: AllianceGenome:SGD:S000005412; FungiDB:YOL052C; VEuPathDB:YOL052C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables adenosylmethionine decarboxylase activity. Involved in pantothenate biosynthetic process; spermidine biosynthetic process; and spermine biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SPE2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (232446..233636, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables adenosylmethionine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosylmethionine decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenosylmethionine decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in pantothenate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermidine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermidine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in spermidine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in spermine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: adenosylmethionine decarboxylase SPE2

NP_014590.1

EC 4.1.1.50

S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

232446..233636 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183306.1 → NP_014590.1 TPA: adenosylmethionine decarboxylase SPE2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014590.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W216, P21182

UniProtKB/TrEMBL

A6ZNF9, B3LJ08, B5VRK0, C7GK18, C8ZHR2, G2WMI3, N1NY29

Conserved Domains (1) summary

cl03253
Location:28 → 396

SAM_decarbox; Adenosylmethionine decarboxylase