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    Mmd monocyte to macrophage differentiation-associated [ Mus musculus (house mouse) ]

    Gene ID: 67468, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mmdprovided by MGI
    Official Full Name
    monocyte to macrophage differentiation-associatedprovided by MGI
    Primary source
    MGI:MGI:1914718
    See related
    Ensembl:ENSMUSG00000003948 AllianceGenome:MGI:1914718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Paqr11; 1200017E07Rik; 1810073C06Rik
    Summary
    Predicted to enable protein kinase activity. Predicted to be involved in positive regulation of neuron differentiation; positive regulation of protein kinase activity; and regulation of protein localization. Predicted to be located in Golgi apparatus. Is expressed in several structures, including alimentary system; cerebral cortex; cranial ganglion; musculoskeletal system; and retina. Orthologous to human MMD (monocyte to macrophage differentiation associated). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 114.9), genital fat pad adult (RPKM 66.5) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mmd in Genome Data Viewer
    Location:
    11 C; 11 54.89 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (90078513..90169399)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (90249276..90278573)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34726 Neighboring gene predicted gene 11494 Neighboring gene STARR-seq mESC enhancer starr_30411 Neighboring gene small integral membrane protein 36 Neighboring gene predicted gene, 42089 Neighboring gene STARR-positive B cell enhancer ABC_E5266 Neighboring gene hepatic leukemia factor Neighboring gene STARR-seq mESC enhancer starr_30412 Neighboring gene predicted gene, 34850

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PAQR11 modulates monocyte-to-macrophage differentiation and pathogenesis of rheumatoid arthritis. Lin Y, et al. Immunology, 2021 May. PMID 33421113, Free PMC Article
    2. Genome-Wide Off-Target Analysis in CRISPR-Cas9 Modified Mice and Their Offspring. Dong Y, et al. G3 (Bethesda), 2019 Nov 5. PMID 31492696, Free PMC Article
    3. Monocyte to macrophage differentiation-associated (MMD) positively regulates ERK and Akt activation and TNF-α and NO production in macrophages. Liu Q, et al. Mol Biol Rep, 2012 May. PMID 22203480
    4. Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D. Huang M, et al. Mol Metab, 2021 May. PMID 33549845, Free PMC Article
    5. Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10. Góñez LJ, et al. Mol Med, 2008 Nov-Dec. PMID 18769639, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D.
      Title: Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D.
    2. PAQR11 modulates monocyte-to-macrophage differentiation and pathogenesis of rheumatoid arthritis.
      Title: PAQR11 modulates monocyte-to-macrophage differentiation and pathogenesis of rheumatoid arthritis.
    3. These results suggested that MMD modulates TNF-alpha and NO production in macrophages, and this process might involves Erk or Akt.
      Title: Monocyte to macrophage differentiation-associated (MMD) positively regulates ERK and Akt activation and TNF-α and NO production in macrophages.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables pore-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    monocyte to macrophage differentiation factor
    Names
    monocyte to macrophage differentiation protein
    progestin and adipoQ receptor family member 11
    progestin and adipoQ receptor family member XI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395423.1 → NP_001382352.1  monocyte to macrophage differentiation factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL626785, AL645990
      UniProtKB/TrEMBL
      Q3UE73
      Conserved Domains (1) summary
      TIGR01065
      Location:28 → 228
      hlyIII; channel protein, hemolysin III family

    2. NM_026178.2 → NP_080454.1  monocyte to macrophage differentiation factor isoform 1

      See identical proteins and their annotated locations for NP_080454.1

      Status: VALIDATED

      Source sequence(s)
      BC021914
      Consensus CDS
      CCDS25240.1
      UniProtKB/Swiss-Prot
      Q3TAU1, Q5SVU7, Q9CQY7
      UniProtKB/TrEMBL
      Q3UE73
      Related
      ENSMUSP00000004050.7, ENSMUST00000004050.7
      Conserved Domains (1) summary
      TIGR01065
      Location:27 → 227
      hlyIII; channel protein, hemolysin III family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      90078513..90169399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQY7.1 GenPept UniProtKB/Swiss-Prot:Q9CQY7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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