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    NTG2 bifunctional N-glycosylase/AP lyase NTG2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854114, updated on 2-Nov-2024

    Summary

    Official Symbol
    NTG2
    Official Full Name
    bifunctional N-glycosylase/AP lyase NTG2
    Primary source
    SGD:S000005403
    Locus tag
    YOL043C
    See related
    AllianceGenome:SGD:S000005403; FungiDB:YOL043C; VEuPathDB:YOL043C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SCR2
    Summary
    Enables DNA-(apurinic or apyrimidinic site) endonuclease activity and oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity. Involved in base-excision repair, AP site formation. Located in nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis 3. Orthologous to human NTHL1 (nth like DNA glycosylase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See NTG2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (248392..249534, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase PSK2 Neighboring gene Pex15p Neighboring gene RNA exonuclease Neighboring gene Nop12p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidized base lesion DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in base-excision repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in base-excision repair, AP site formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in base-excision repair, AP site formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in base-excision repair, AP site formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    bifunctional N-glycosylase/AP lyase NTG2
    NP_014599.1
    • DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      248392..249534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183297.1NP_014599.1  TPA: bifunctional N-glycosylase/AP lyase NTG2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014599.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W223, Q08214
      UniProtKB/TrEMBL
      A6ZNG6, B3LJ15, B5VRL0, C7GK12, C8ZHS1, G2WMJ0, N1P2S0
      Conserved Domains (1) summary
      COG0177
      Location:96343
      Nth; Endonuclease III [Replication, recombination and repair]