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    Kazn kazrin, periplakin interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 71529, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kaznprovided by MGI
    Official Full Name
    kazrin, periplakin interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1918779
    See related
    Ensembl:ENSMUSG00000040606 AllianceGenome:MGI:1918779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kaz; Kazrin; 2310007B04Rik; 9030409G11Rik
    Summary
    Predicted to be involved in keratinization. Predicted to be located in several cellular components, including cornified envelope; desmosome; and nuclear speck. Is expressed in several structures, including blastocyst; early embryo; embryo ectoderm; extraembryonic component; and genitourinary system. Orthologous to human KAZN (kazrin, periplakin interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 9.1), cerebellum adult (RPKM 6.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kazn in Genome Data Viewer
    Location:
    4 D3- E1; 4 75.46 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141829701..142801231, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (142102390..142239401, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930455G09 gene Neighboring gene STARR-seq mESC enhancer starr_11942 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:141636026-141636227 Neighboring gene transmembrane protein 51 Neighboring gene Tmem51 opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_11946 Neighboring gene STARR-seq mESC enhancer starr_11949 Neighboring gene STARR-seq mESC enhancer starr_11950 Neighboring gene predicted gene, 35581 Neighboring gene STARR-seq mESC enhancer starr_11954 Neighboring gene STARR-seq mESC enhancer starr_11955 Neighboring gene predicted gene, 35531 Neighboring gene predicted gene, 54267 Neighboring gene STARR-seq mESC enhancer starr_11956 Neighboring gene STARR-seq mESC enhancer starr_11957 Neighboring gene predicted gene, 42339 Neighboring gene predicted gene, 35752 Neighboring gene STARR-seq mESC enhancer starr_11958 Neighboring gene predicted gene, 42342 Neighboring gene predicted gene, 42340 Neighboring gene predicted gene, 42341 Neighboring gene STARR-seq mESC enhancer starr_11959 Neighboring gene STARR-seq mESC enhancer starr_11960 Neighboring gene STARR-positive B cell enhancer ABC_E2723 Neighboring gene microRNA 7021 Neighboring gene PR domain containing 2, with ZNF domain Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Kazrin promotes dynein/dynactin-dependent traffic from early to recycling endosomes. Hernandez-Perez I, et al. Elife, 2023 Apr 25. PMID 37096882, Free PMC Article
    2. Dynamics and unexpected localization of the plakin binding protein, kazrin, in mouse eggs and early embryos. Gallicano GI, et al. Dev Dyn, 2005 Sep. PMID 16086310
    3. Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane. Groot KR, et al. J Cell Biol, 2004 Aug 30. PMID 15337775, Free PMC Article
    4. Exons 5-15 of kazrin are dispensable for murine epidermal morphogenesis and homeostasis. Chhatriwala MK, et al. J Invest Dermatol, 2012 Aug. PMID 22513779, Free PMC Article
    5. Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease. Youlten SE, et al. Nat Commun, 2021 May 5. PMID 33953184, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kazrin promotes dynein/dynactin-dependent traffic from early to recycling endosomes.
      Title: Kazrin promotes dynein/dynactin-dependent traffic from early to recycling endosomes.
    2. exons 5-15 of kazrin, encoding the nuclear localization signal and C-terminal domain, are not required for epidermal development and function
      Title: Exons 5-15 of kazrin are dispensable for murine epidermal morphogenesis and homeostasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in keratinization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in desmosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kazrin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109684.2 → NP_001103154.1  kazrin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL663037, MF597748
      UniProtKB/TrEMBL
      G3UY74, G3UZT9
      Related
      ENSMUSP00000133972.3, ENSMUST00000172864.9
      Conserved Domains (1) summary
      pfam13863
      Location:129 → 242
      DUF4200; Domain of unknown function (DUF4200)

    2. NM_001109685.2 → NP_001103155.1  kazrin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL663037, BX537122
      Consensus CDS
      CCDS51350.1
      UniProtKB/TrEMBL
      G3UZT9
      Related
      ENSMUSP00000038835.4, ENSMUST00000036476.10
      Conserved Domains (1) summary
      TIGR02168
      Location:71 → 248
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. NM_144531.4 → NP_653114.3  kazrin isoform 1

      See identical proteins and their annotated locations for NP_653114.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL663037, MF597748
      UniProtKB/Swiss-Prot
      A2AC34, B1B0N1, Q69ZS8, Q8BIY2, Q8R1X4
      UniProtKB/TrEMBL
      F6RLJ7
      Related
      ENSMUSP00000116071.3, ENSMUST00000155023.9
      Conserved Domains (4) summary
      cd09564
      Location:447 → 516
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:526 → 590
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:612 → 683
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:2 → 245
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      141829701..142801231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164437.1 → XP_036020330.1  kazrin isoform X2

      UniProtKB/TrEMBL
      F6RLJ7
      Conserved Domains (4) summary
      cd09564
      Location:535 → 604
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:614 → 678
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:700 → 771
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:69 → 333
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_036164436.1 → XP_036020329.1  kazrin isoform X1

      UniProtKB/TrEMBL
      F6RLJ7
      Conserved Domains (4) summary
      cd09564
      Location:536 → 605
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:615 → 679
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:701 → 772
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:69 → 333
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_036164443.1 → XP_036020336.1  kazrin isoform X6

      UniProtKB/Swiss-Prot
      A2AC34, B1B0N1, Q69ZS8, Q8BIY2, Q8R1X4
      UniProtKB/TrEMBL
      F6RLJ7
      Conserved Domains (4) summary
      cd09564
      Location:447 → 516
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:526 → 590
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:612 → 683
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:2 → 245
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_036164441.1 → XP_036020334.1  kazrin isoform X5

      UniProtKB/TrEMBL
      F6RLJ7
      Conserved Domains (4) summary
      cd09564
      Location:448 → 517
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:527 → 591
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:613 → 684
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:2 → 245
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_036164438.1 → XP_036020331.1  kazrin isoform X3

      UniProtKB/TrEMBL
      F6RLJ7
      Conserved Domains (4) summary
      cd09564
      Location:454 → 523
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:533 → 597
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:619 → 690
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:8 → 251
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_036164439.1 → XP_036020332.1  kazrin isoform X4

      UniProtKB/TrEMBL
      F6RLJ7
      Conserved Domains (4) summary
      cd09564
      Location:453 → 522
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:532 → 596
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:618 → 689
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:8 → 251
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_036164442.1 → XP_036020335.1  kazrin isoform X6

      UniProtKB/Swiss-Prot
      A2AC34, B1B0N1, Q69ZS8, Q8BIY2, Q8R1X4
      UniProtKB/TrEMBL
      F6RLJ7
      Conserved Domains (4) summary
      cd09564
      Location:447 → 516
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:526 → 590
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:612 → 683
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:2 → 245
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. XM_036164440.1 → XP_036020333.1  kazrin isoform X5

      UniProtKB/TrEMBL
      F6RLJ7
      Conserved Domains (4) summary
      cd09564
      Location:448 → 517
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:527 → 591
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:613 → 684
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:2 → 245
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    9. XM_036164445.1 → XP_036020338.1  kazrin isoform X8

      UniProtKB/TrEMBL
      F6RLJ7
      Conserved Domains (4) summary
      cd09564
      Location:436 → 505
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:515 → 579
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:601 → 672
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:72 → 246
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    10. XM_036164444.1 → XP_036020337.1  kazrin isoform X7

      UniProtKB/TrEMBL
      F6RLJ7
      Conserved Domains (4) summary
      cd09564
      Location:437 → 506
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:516 → 580
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:602 → 673
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:72 → 246
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    11. XM_036164449.1 → XP_036020342.1  kazrin isoform X12

      UniProtKB/TrEMBL
      Q8BJ43
      Conserved Domains (3) summary
      cd09564
      Location:120 → 189
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:199 → 263
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:285 → 356
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3

    12. XM_036164448.1 → XP_036020341.1  kazrin isoform X11

      Conserved Domains (1) summary
      COG1196
      Location:69 → 333
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    13. XM_036164447.1 → XP_036020340.1  kazrin isoform X10

      Conserved Domains (1) summary
      COG1196
      Location:69 → 333
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    14. XM_036164446.1 → XP_036020339.1  kazrin isoform X9

      Conserved Domains (1) summary
      COG1196
      Location:69 → 333
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_004941964.1 RNA Sequence

    2. XR_004941963.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZS8.2 GenPept UniProtKB/Swiss-Prot:Q69ZS8

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