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    HXT6 hexose transporter HXT6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851944, updated on 2-Nov-2024

    Summary

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    Official Symbol
    HXT6
    Official Full Name
    hexose transporter HXT6
    Primary source
    SGD:S000002751
    Locus tag
    YDR343C
    See related
    AllianceGenome:SGD:S000002751; FungiDB:YDR343C; VEuPathDB:YDR343C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables D-glucose transmembrane transporter activity. Predicted to be involved in carbohydrate transport. Located in mitochondrial membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See HXT6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1159608..1161320, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene arginine--tRNA ligase Neighboring gene hexose transporter HXT7 Neighboring gene uncharacterized protein Neighboring gene hexose transporter HXT3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Engineering of an endogenous hexose transporter into a specific D-xylose transporter facilitates glucose-xylose co-consumption in Saccharomyces cerevisiae. Nijland JG, et al. Biotechnol Biofuels, 2014. PMID 25505932, Free PMC Article
    2. Multiple duplications of yeast hexose transport genes in response to selection in a glucose-limited environment. Brown CJ, et al. Mol Biol Evol, 1998 Aug. PMID 9718721
    3. Starvation-induced degradation of yeast hexose transporter Hxt7p is dependent on endocytosis, autophagy and the terminal sequences of the permease. Krampe S, et al. FEBS Lett, 2002 Feb 27. PMID 11904149
    4. Replicative aging is associated with loss of genetic heterogeneity from extrachromosomal circular DNA in Saccharomyces cerevisiae. Prada-Luengo I, et al. Nucleic Acids Res, 2020 Aug 20. PMID 32609810, Free PMC Article
    5. The Valley-of-Death: reciprocal sign epistasis constrains adaptive trajectories in a constant, nutrient limiting environment. Chiotti KE, et al. Genomics, 2014 Dec. PMID 25449178, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two glucose signaling pathways converge onto Csr2 to regulate hexose transporter Hxt6 endocytosis by glucose availability.
      Title: Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis.
    2. demonstrated the interaction of Rod1 with Hxt6 and showed that the localization of the Rod1-Hxt6 complex at the plasma membrane is affected by carbon source and is reduced upon overexpression of SNF1 and BMH2
      Title: Regulation of the Yeast Hxt6 Hexose Transporter by the Rod1 α-Arrestin, the Snf1 Protein Kinase, and the Bmh2 14-3-3 Protein.
    3. Variation in the copy number of HXT6/HTX7 locus was observed in a survey of ~70 yeast strains.
      Title: Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape.
    4. Three members of the VID and GID gene families, VID30/GID1, GID2, and VID28/GID5 are needed for the rapamycin or nitrogen starvation-induced degradation of the high-affinity hexose transporter Hxt7p is shown here.
      Title: Components of the Vid30c are needed for the rapamycin-induced degradation of the high-affinity hexose transporter Hxt7p in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-glucose transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mannose transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose transmembrane transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mannose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hexose transporter HXT6
    NP_010630.1
    • High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1159608..1161320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180651.1 → NP_010630.1  TPA: hexose transporter HXT6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010630.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSX4, P39003
      UniProtKB/TrEMBL
      E9P9G7
      Conserved Domains (2) summary
      cd06174
      Location:69 → 514
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:68 → 528
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39003.2

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