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    ZNF791 zinc finger protein 791 [ Homo sapiens (human) ]

    Gene ID: 163049, updated on 28-Oct-2024

    Summary

    Official Symbol
    ZNF791provided by HGNC
    Official Full Name
    zinc finger protein 791provided by HGNC
    Primary source
    HGNC:HGNC:26895
    See related
    Ensembl:ENSG00000173875 AllianceGenome:HGNC:26895
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 9.3), ovary (RPKM 5.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF791 in Genome Data Viewer
    Location:
    19p13.13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12610920..12633834)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12735260..12758349)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12721734..12744648)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene phosphoglycerate kinase 1, pseudogene 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:12690738-12691937 Neighboring gene zinc finger protein 490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12724145-12724645 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10154 Neighboring gene vomeronasal 2 receptor 16 pseudogene Neighboring gene uncharacterized LOC105372279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12750843-12751363 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:12754106-12755305 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14063 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10155 Neighboring gene ribosomal protein L10 pseudogene 16 Neighboring gene mannosidase alpha class 2B member 1 Neighboring gene MPRA-validated peak3365 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12775226-12776174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12776175-12777122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10156

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 791 (ZNF791) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90396, MGC126179, MGC126180

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153358.3NP_699189.2  zinc finger protein 791

      See identical proteins and their annotated locations for NP_699189.2

      Status: VALIDATED

      Source sequence(s)
      AC010422, AK074877, AK307775, BC106937, BP319293, DC329382
      Consensus CDS
      CCDS12273.1
      UniProtKB/Swiss-Prot
      B7Z586, Q3KP31, Q8NC99
      Related
      ENSP00000342974.4, ENST00000343325.9
      Conserved Domains (3) summary
      COG5048
      Location:98573
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442462
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:344
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      12610920..12633834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      12735260..12758349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)