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    GPAT3 glycerol-3-phosphate acyltransferase 3 [ Homo sapiens (human) ]

    Gene ID: 84803, updated on 3-Nov-2024

    Summary

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    Official Symbol
    GPAT3provided by HGNC
    Official Full Name
    glycerol-3-phosphate acyltransferase 3provided by HGNC
    Primary source
    HGNC:HGNC:28157
    See related
    Ensembl:ENSG00000138678 MIM:610958; AllianceGenome:HGNC:28157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAG1; AGPAT8; AGPAT9; AGPAT10; AGPAT 10; HMFN0839; LPAAT-theta
    Summary
    This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
    Expression
    Broad expression in kidney (RPKM 23.1), duodenum (RPKM 10.2) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPAT3 in Genome Data Viewer
    Location:
    4q21.23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (83535587..83605875)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (86865686..86935953)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (84457067..84527028)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15542 Neighboring gene solute carrier family 25 member 14 pseudogene 1 Neighboring gene abraxas 1, BRCA1 A complex subunit Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:84469077-84470276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15543 Neighboring gene ribosomal protein L30 pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 7334 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:84539256-84540455 Neighboring gene Sharpr-MPRA regulatory region 4612 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:84557857-84558358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21689 Neighboring gene VISTA enhancer hs712 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:84702313-84703031 Neighboring gene uncharacterized LOC105377315 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:84771005-84771616 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:84771617-84772228 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:84775825-84777024 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:84843248-84843790 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:84843791-84844331 Neighboring gene NANOG hESC enhancer GRCh37_chr4:84917176-84917884 Neighboring gene long intergenic non-protein coding RNA 2994 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:85048206-85048769 Neighboring gene RNA, U6 small nuclear 774, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Metastasis-associated gene, mag-1 improves tumour microenvironmental adaptation and potentiates tumour metastasis. Wang Y, et al. J Cell Mol Med, 2012 Dec. PMID 22985252, Free PMC Article
    2. GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway. Fan G, et al. Cell Death Dis, 2023 Mar 24. PMID 36964139, Free PMC Article
    3. Mycobacterium leprae promotes triacylglycerol de novo synthesis through induction of GPAT3 expression in human premonocytic THP-1 cells. Tanigawa K, et al. PLoS One, 2021. PMID 33770127, Free PMC Article
    4. [Identification of novel metastasis associated genes MAG-1 and MAG-2]. Zhang J, et al. Zhongguo Fei Ai Za Zhi, 2003 Dec 20. PMID 21310131
    5. GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis. Shan D, et al. J Lipid Res, 2010 Jul. PMID 20181984, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mycobacterium leprae promotes triacylglycerol de novo synthesis through induction of GPAT3 expression in human premonocytic THP-1 cells.
      Title: Mycobacterium leprae promotes triacylglycerol de novo synthesis through induction of GPAT3 expression in human premonocytic THP-1 cells.
    2. GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway.
      Title: GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway.
    3. Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.
      Title: Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.
    4. Data show that 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) inhibit cell growth by regulating expression of KLF4/LASS2/V-ATPase proteins in breast cancer.
      Title: AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer.
    5. findings identified a direct role that mag-1 played in metastasis and implicated its function in cellular adaptation to tumour microenvironment
      Title: Metastasis-associated gene, mag-1 improves tumour microenvironmental adaptation and potentiates tumour metastasis.
    6. Results reveal a link between the lipogenic effects of insulin and microsomal GPAT3 and GPAT4, implying their importance in glycerolipid biosynthesis.
      Title: GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis.
    7. LPAAT-theta gene consisted of 12 exons and 11 introns, and mapped to chromosome 4q21.23, was ubiquitously expressed in 18 human tissues and overexpression of LPAAT-theta can induce mTOR-dependent p70S6K and 4EBP1 phosphorylation in HEK293T cells.
      Title: Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11324

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    NOT enables glycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in regulation of TOR signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    glycerol-3-phosphate acyltransferase 3
    Names
    1-AGP acyltransferase 9
    1-AGPAT 9
    1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10
    1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9
    1-acylglycerol-3-phosphate O-acyltransferase 8
    1-acylglycerol-3-phosphate O-acyltransferase 9
    GPAT-3
    MAG-1
    acyl-CoA:glycerol-3-phosphate acyltransferase 3
    endoplasmic reticulum associated GPAT
    hGPAT3
    lung cancer metastasis-associated protein 1
    lysophosphatidic acid acyltransferase theta
    testis secretory sperm-binding protein Li 213e
    NP_001243350.1
    NP_001243351.1
    NP_116106.2
    XP_011530686.1
    XP_016864269.1
    XP_016864270.1
    XP_054207093.1
    XP_054207094.1
    XP_054207095.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256421.1 → NP_001243350.1  glycerol-3-phosphate acyltransferase 3

      See identical proteins and their annotated locations for NP_001243350.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC021192, AC096768, AK055749, BM841009
      Consensus CDS
      CCDS3606.1
      UniProtKB/Swiss-Prot
      Q53EU6, Q68CJ4, Q6GPI6, Q96NA3
      UniProtKB/TrEMBL
      A0A024RDG5, A0A140VK86
      Related
      ENSP00000378651.2, ENST00000395226.6
      Conserved Domains (1) summary
      cd07991
      Location:199 → 408
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    2. NM_001256422.1 → NP_001243351.1  glycerol-3-phosphate acyltransferase 3

      See identical proteins and their annotated locations for NP_001243351.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC021192, BM841009, DA393801
      Consensus CDS
      CCDS3606.1
      UniProtKB/Swiss-Prot
      Q53EU6, Q68CJ4, Q6GPI6, Q96NA3
      UniProtKB/TrEMBL
      A0A024RDG5, A0A140VK86
      Related
      ENSP00000482571.1, ENST00000611707.4
      Conserved Domains (1) summary
      cd07991
      Location:199 → 408
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    3. NM_032717.5 → NP_116106.2  glycerol-3-phosphate acyltransferase 3

      See identical proteins and their annotated locations for NP_116106.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC096768, AY358100, BM841009, DA673378
      Consensus CDS
      CCDS3606.1
      UniProtKB/Swiss-Prot
      Q53EU6, Q68CJ4, Q6GPI6, Q96NA3
      UniProtKB/TrEMBL
      A0A024RDG5, A0A140VK86
      Related
      ENSP00000264409.4, ENST00000264409.5
      Conserved Domains (1) summary
      cd07991
      Location:199 → 408
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      83535587..83605875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008780.2 → XP_016864269.1  glycerol-3-phosphate acyltransferase 3 isoform X1

    2. XM_017008781.2 → XP_016864270.1  glycerol-3-phosphate acyltransferase 3 isoform X2

      UniProtKB/Swiss-Prot
      Q53EU6, Q68CJ4, Q6GPI6, Q96NA3
      UniProtKB/TrEMBL
      A0A024RDG5, A0A140VK86
      Conserved Domains (1) summary
      cd07991
      Location:199 → 408
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    3. XM_011532384.3 → XP_011530686.1  glycerol-3-phosphate acyltransferase 3 isoform X3

      See identical proteins and their annotated locations for XP_011530686.1

      Conserved Domains (1) summary
      cd07991
      Location:121 → 330
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      86865686..86935953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351118.1 → XP_054207093.1  glycerol-3-phosphate acyltransferase 3 isoform X1

    2. XM_054351119.1 → XP_054207094.1  glycerol-3-phosphate acyltransferase 3 isoform X2

      UniProtKB/Swiss-Prot
      Q53EU6, Q68CJ4, Q6GPI6, Q96NA3
      UniProtKB/TrEMBL
      A0A024RDG5, A0A140VK86

    3. XM_054351120.1 → XP_054207095.1  glycerol-3-phosphate acyltransferase 3 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53EU6.2 GenPept UniProtKB/Swiss-Prot:Q53EU6

    Gene LinkOut

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