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    Serpinb9c serine (or cysteine) peptidase inhibitor, clade B, member 9c [ Mus musculus (house mouse) ]

    Gene ID: 20707, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Serpinb9cprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B, member 9cprovided by MGI
    Primary source
    MGI:MGI:894669
    See related
    Ensembl:ENSMUSG00000021404 AllianceGenome:MGI:894669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nk9; Spi11; 3830421J05Rik
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protease binding activity; and serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of endopeptidase activity; and protection from natural killer cell mediated cytotoxicity. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in cytoplasm and extracellular space. Orthologous to human SERPINB9 (serpin family B member 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 27.0) See more
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    Genomic context

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    See Serpinb9c in Genome Data Viewer
    Location:
    13 A3.3; 13 13.82 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (33333258..33343737, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (33149275..33159754, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prohibitin pseudogene Neighboring gene craniofacial development protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34117 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9d Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9e

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). Sun J, et al. J Biol Chem, 1997 Jun 13. PMID 9182575
    2. Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse. Kaiserman D, et al. Genomics, 2002 Mar. PMID 11863365
    3. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
    4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protection from natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine (or cysteine) proteinase inhibitor, clade B, member 9c
    Names
    ovalbumin
    serine protease inhibitor 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164524.1 → NP_001157996.1  serine (or cysteine) proteinase inhibitor, clade B, member 9c isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK014448, BU757932, CN704519
      Consensus CDS
      CCDS49226.1
      UniProtKB/TrEMBL
      I7HJI5, Q80WW4
      Related
      ENSMUSP00000021837.4, ENSMUST00000021837.10
      Conserved Domains (1) summary
      cl00137
      Location:17 → 387
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    2. NM_011453.6 → NP_035583.1  serine (or cysteine) proteinase inhibitor, clade B, member 9c isoform 2

      See identical proteins and their annotated locations for NP_035583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      BC051664, BU757932
      Consensus CDS
      CCDS36629.1
      UniProtKB/TrEMBL
      Q80WW4, Q9D6A7
      Related
      ENSMUSP00000105913.2, ENSMUST00000110284.8
      Conserved Domains (1) summary
      cd19956
      Location:2 → 356
      serpinB; serpin B family, ov-serpins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      33333258..33343737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516619.2 → XP_006516682.1  serine (or cysteine) proteinase inhibitor, clade B, member 9c isoform X2

      See identical proteins and their annotated locations for XP_006516682.1

      UniProtKB/TrEMBL
      Q80WW4, Q9D6A7
      Conserved Domains (1) summary
      cd19956
      Location:2 → 356
      serpinB; serpin B family, ov-serpins

    2. XM_006516620.1 → XP_006516683.1  serine (or cysteine) proteinase inhibitor, clade B, member 9c isoform X2

      See identical proteins and their annotated locations for XP_006516683.1

      UniProtKB/TrEMBL
      Q80WW4, Q9D6A7
      Conserved Domains (1) summary
      cd19956
      Location:2 → 356
      serpinB; serpin B family, ov-serpins

    3. XM_006516618.4 → XP_006516681.1  serine (or cysteine) proteinase inhibitor, clade B, member 9c isoform X1

      UniProtKB/TrEMBL
      Q80WW4
      Conserved Domains (1) summary
      cl38926
      Location:28 → 403
      serpin; SERine Proteinase INhibitors (serpin) family
    Nucleotide Protein Strain
    Heading Accession and Version

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