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    Ssr4 signal sequence receptor subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29435, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ssr4provided by RGD
    Official Full Name
    signal sequence receptor subunit 4provided by RGD
    Primary source
    RGD:62034
    See related
    Ensembl:ENSRNOG00000053172 AllianceGenome:RGD:62034
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Part of Sec61 translocon complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iy. Orthologous to human SSR4 (signal sequence receptor subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 529.1), Spleen (RPKM 460.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ssr4 in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156675658..156679545)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151524191..151528218)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156995763..156999702, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene SRSF protein kinase 3 Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene PDZ domain containing 4 Neighboring gene L1 cell adhesion molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A tetrameric complex of membrane proteins in the endoplasmic reticulum. Hartmann E, et al. Eur J Biochem, 1993 Jun 1. PMID 7916687
    2. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article
    3. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of Sec61 translocon complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    translocon-associated protein subunit delta
    Names
    SSR-delta
    TRAP-delta
    signal sequence receptor 4
    signal sequence receptor subunit delta
    signal sequence receptor, delta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017199.1 → NP_058895.1  translocon-associated protein subunit delta precursor

      See identical proteins and their annotated locations for NP_058895.1

      Status: PROVISIONAL

      Source sequence(s)
      Z19087
      UniProtKB/Swiss-Prot
      Q07984
      UniProtKB/TrEMBL
      A6KRU9, A6KRV0
      Conserved Domains (1) summary
      pfam05404
      Location:22 → 172
      TRAP-delta; Translocon-associated protein, delta subunit precursor (TRAP-delta)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      156675658..156679545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279850.1 → XP_063135920.1  translocon-associated protein subunit delta isoform X2

    2. XM_063279851.1 → XP_063135921.1  translocon-associated protein subunit delta isoform X3

    3. XM_006229571.5 → XP_006229633.1  translocon-associated protein subunit delta isoform X1

      UniProtKB/TrEMBL
      A0A8L2R221, A6KRU9
      Related
      ENSRNOP00000070206.2
      Conserved Domains (1) summary
      pfam05404
      Location:22 → 171
      TRAP-delta; Translocon-associated protein, delta subunit precursor (TRAP-delta)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07984.1 GenPept UniProtKB/Swiss-Prot:Q07984

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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