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    Timm8b translocase of inner mitochondrial membrane 8 homolog B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64372, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Timm8bprovided by RGD
    Official Full Name
    translocase of inner mitochondrial membrane 8 homolog Bprovided by RGD
    Primary source
    RGD:619840
    See related
    AllianceGenome:RGD:619840
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ddp2
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in protein transport. Predicted to be located in mitochondrion. Orthologous to human TIMM8B (translocase of inner mitochondrial membrane 8 homolog B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 1740.5), Muscle (RPKM 1543.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Timm8b in Genome Data Viewer
    Location:
    8q23
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (59850737..59852117)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (50954350..50955730)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55037750..55039130)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene interleukin 18 Neighboring gene testis expressed 12 Neighboring gene succinate dehydrogenase complex subunit D Neighboring gene NKAP domain containing 1 Neighboring gene PIH1 domain containing 2 Neighboring gene dihydrolipoamide S-acetyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Assembly of β-barrel proteins in the mitochondrial outer membrane. Höhr AI, et al. Biochim Biophys Acta, 2015 Jan. PMID 25305573
    2. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. Bauer MF, et al. FEBS Lett, 1999 Dec 24. PMID 10611480
    3. Gene expression profiling of purified rat retinal ganglion cells. Farkas RH, et al. Invest Ophthalmol Vis Sci, 2004 Aug. PMID 15277470
    4. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Pieragostino D, et al. Mol Biosyst, 2013 Jun. PMID 23580065
    5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim8 B
    Names
    deafness dystonia protein 2 homolog
    small zinc finger-like protein DDP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022541.2 → NP_071986.1  mitochondrial import inner membrane translocase subunit Tim8 B

      See identical proteins and their annotated locations for NP_071986.1

      Status: VALIDATED

      Source sequence(s)
      AF196315, CF977529
      UniProtKB/Swiss-Prot
      P62078
      UniProtKB/TrEMBL
      A6J4E1
      Conserved Domains (1) summary
      pfam02953
      Location:16 → 74
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      59850737..59852117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62078.1 GenPept UniProtKB/Swiss-Prot:P62078

    Gene LinkOut

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