Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Pcsk1nprovided by RGD
Full Name: proprotein convertase subtilisin/kexin type 1 inhibitorprovided by RGD
Primary source: RGD:3617
See related: EnsemblRapid:ENSRNOG00000046021 AllianceGenome:RGD:3617
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Saas
Summary: Enables endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity and neuropeptide signaling pathway. Predicted to act upstream of or within peptide hormone processing; response to cold; and response to dietary excess. Located in extracellular space. Used to study obesity. Orthologous to human PCSK1N (proprotein convertase subtilisin/kexin type 1 inhibitor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 444.0), Adrenal (RPKM 280.3) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (17251963..17255405, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (14580036..14583478, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (15324263..15327705, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pcsk1n (e-PCR), detects polymorphism
- UniSTS:532490

AI848336 (e-PCR)
- UniSTS:186167

BI283701 (e-PCR)
- UniSTS:243617

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in peptide hormone processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptide hormone processing	ISO Inferred from Sequence Orthology more info
involved_in response to cold	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cold	ISO Inferred from Sequence Orthology more info
involved_in response to dietary excess	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to dietary excess	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IEA Inferred from Electronic Annotation more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proSAAS

Names: granin-like neuroendocrine peptide; pro-SAAS; proSAAS-like; proprotein convertase 1 inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.