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    Acadvl acyl-CoA dehydrogenase, very long chain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25363, updated on 2-Nov-2024

    Summary

    Official Symbol
    Acadvlprovided by RGD
    Official Full Name
    acyl-CoA dehydrogenase, very long chainprovided by RGD
    Primary source
    RGD:2014
    See related
    EnsemblRapid:ENSRNOG00000018114 AllianceGenome:RGD:2014
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    VLCAD
    Summary
    Enables acyl-CoA dehydrogenase activity and nucleoside phosphate binding activity. Involved in fatty acid beta-oxidation. Located in mitochondrial inner membrane. Biomarker of metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 1922.6), Liver (RPKM 1150.6) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Acadvl in Genome Data Viewer
    Location:
    10q24
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55231558..55236786, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54732875..54738102, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56619321..56624468, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene PHD finger protein 23 Neighboring gene dishevelled segment polarity protein 2 Neighboring gene microRNA 324 Neighboring gene discs large MAGUK scaffold protein 4 Neighboring gene asialoglycoprotein receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC93660

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty-acyl-CoA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables long-chain fatty acyl-CoA dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables long-chain fatty acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables very-long-chain fatty acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables very-long-chain fatty acyl-CoA dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables very-long-chain fatty acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables very-long-chain fatty acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid beta-oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within fatty acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fatty acid oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cold IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to cold ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in temperature homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in temperature homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    very long-chain specific acyl-CoA dehydrogenase, mitochondrial
    Names
    VLCAD very-long-chain acyl-CoA dehydrogenase
    Very long chain Acyl-Coa dehydrogenase
    acyl-Coenzyme A dehydrogenase, very long chain
    NP_037023.1
    XP_063124528.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012891.2NP_037023.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_037023.1

      Status: PROVISIONAL

      Source sequence(s)
      D30647
      UniProtKB/Swiss-Prot
      P45953
      UniProtKB/TrEMBL
      F7FEX1, Q5M9H2
      Related
      ENSRNOP00000024973.4, ENSRNOT00000024973.8
      Conserved Domains (2) summary
      cd01161
      Location:72481
      VLCAD; Very long chain acyl-CoA dehydrogenase
      COG1960
      Location:100473
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55231558..55236786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268458.1XP_063124528.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1