Aldh3a1 aldehyde dehydrogenase 3 family, member A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aldh3a1provided by RGD
Official Full Name: aldehyde dehydrogenase 3 family, member A1provided by RGD
Primary source: RGD:2088
See related: EnsemblRapid:ENSRNOG00000002331 AllianceGenome:RGD:2088
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AHDC; Aldh; Ahd-c; Aldh3
Summary: Enables 3-chloroallyl aldehyde dehydrogenase activity. Involved in several processes, including response to cAMP; response to glucocorticoid; and response to hypoxia. Located in cytosol. Human ortholog(s) of this gene implicated in arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 46.8), Heart (RPKM 25.7) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (46392464..46402151)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (45892993..45902680)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (47490168..47499855)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Different doxorubicin formulations decreased liver expression of ALDH3A1.
Title: Different doxorubicin formulations affect plasma 4-hydroxy-2-nonenal and gene expression of aldehyde dehydrogenase 3A1 and thioredoxin reductase 2 in rat.
Decreased function of dopamine mediated through DA D(2) receptor in the cerebral cortex and brain stem enhanced the brain, plasma and liver ALDH activity in ethanol treated rats.
Title: Decreased dopamine D(2) receptor function in cerebral cortex and brain stem: their role in hepatic ALDH regulation in ethanol treated rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-chloroallyl aldehyde dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-chloroallyl aldehyde dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables alcohol dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables alcohol dehydrogenase (NADP+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables aldehyde dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables benzaldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular aldehyde metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular aldehyde metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular aldehyde metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular aldehyde metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to glucocorticoid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aldehyde dehydrogenase, dimeric NADP-preferring

Names: Aldehyde dehydrogenase (Ahd-c); HTC-ALDH; aldehyde dehydrogenase 3A1; aldehyde dehydrogenase class 3; aldehyde dehydrogenase family 3 member A1; aldehyde dehydrogenase family 3 subfamily A1; tumor-associated aldehyde dehydrogenase tumor ALDH

NP_114178.1

EC 1.2.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031972.2 → NP_114178.1 aldehyde dehydrogenase, dimeric NADP-preferring

See identical proteins and their annotated locations for NP_114178.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P11883

UniProtKB/TrEMBL

A0A8L2Q0S9, A6HF73

Related

ENSRNOP00000003182.6, ENSRNOT00000003182.7

Conserved Domains (1) summary

cd07132
Location:5 → 447

ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins