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    Srsf11 serine and arginine rich splicing factor 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502603, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Srsf11provided by RGD
    Official Full Name
    serine and arginine rich splicing factor 11provided by RGD
    Primary source
    RGD:1559953
    See related
    EnsemblRapid:ENSRNOG00000029592 AllianceGenome:RGD:1559953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sfrs11
    Summary
    Predicted to enable RNA binding activity and identical protein binding activity. Predicted to be involved in RNA splicing. Predicted to be located in nuclear speck. Predicted to be active in nucleoplasm. Orthologous to human SRSF11 (serine and arginine rich splicing factor 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 166.0), Spleen (RPKM 136.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srsf11 in Genome Data Viewer
    Location:
    2q45
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (249733464..249760296, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (247074623..247101460, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (264837463..264864296, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A, pseudogene 19 Neighboring gene cystathionine gamma-lyase Neighboring gene ankyrin repeat domain 13C Neighboring gene leucine rich repeat containing 40 Neighboring gene leucine rich repeat containing 7 Neighboring gene transfer RNA alanine (anticodon AGC) 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Discovering transcription and splicing networks in myelodysplastic syndromes. Wang H, et al. PLoS One, 2013. PMID 24244432, Free PMC Article
    2. Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders. Stamova BS, et al. Mol Autism, 2013 Sep 4. PMID 24007566, Free PMC Article
    3. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, et al. Nucleic Acids Res, 2007. PMID 17537823, Free PMC Article
    4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116323

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 11
    Names
    splicing factor, arginine/serine-rich 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399822.1 → NP_001386751.1  serine/arginine-rich splicing factor 11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HWT5, D3ZBT0, Q4KLK1
      Related
      ENSRNOP00000101625.1, ENSRNOT00000127924.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      249733464..249760296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233542.5 → XP_006233604.1  serine/arginine-rich splicing factor 11 isoform X3

      UniProtKB/TrEMBL
      D3ZBT0, Q4KLK1
      Conserved Domains (1) summary
      cd12518
      Location:62 → 141
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    2. XM_008761567.4 → XP_008759789.1  serine/arginine-rich splicing factor 11 isoform X2

      UniProtKB/TrEMBL
      D3ZBT0, Q4KLK1
      Conserved Domains (1) summary
      cd12518
      Location:62 → 141
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    3. XM_006233540.5 → XP_006233602.1  serine/arginine-rich splicing factor 11 isoform X1

      UniProtKB/TrEMBL
      A0A0G2QC38, D3ZBT0, Q4KLK1
      Conserved Domains (1) summary
      cd12518
      Location:62 → 141
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    4. XM_008761569.4 → XP_008759791.1  serine/arginine-rich splicing factor 11 isoform X5

      UniProtKB/TrEMBL
      D3ZBT0, Q4KLK1
      Conserved Domains (1) summary
      cd12518
      Location:27 → 106
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    5. XM_006233543.5 → XP_006233605.1  serine/arginine-rich splicing factor 11 isoform X4

      See identical proteins and their annotated locations for XP_006233605.1

      UniProtKB/TrEMBL
      D3ZBT0, Q4KLK1
      Related
      ENSRNOP00000043202.7, ENSRNOT00000044236.7
      Conserved Domains (1) summary
      cd12518
      Location:41 → 120
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    6. XM_039102967.2 → XP_038958895.1  serine/arginine-rich splicing factor 11 isoform X7

      UniProtKB/TrEMBL
      A6HWT7

    7. XM_063282413.1 → XP_063138483.1  serine/arginine-rich splicing factor 11 isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001035255.1: Suppressed sequence

      Description
      NM_001035255.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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