U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    As3mt arsenite methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140925, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    As3mtprovided by RGD
    Official Full Name
    arsenite methyltransferaseprovided by RGD
    Primary source
    RGD:621325
    See related
    EnsemblRapid:ENSRNOG00000020081 AllianceGenome:RGD:621325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyt19
    Summary
    Enables arsenite methyltransferase activity. Involved in arsonoacetate metabolic process and toxin metabolic process. Acts upstream of or within response to arsenic-containing substance. Located in cytosol. Orthologous to human AS3MT (arsenite methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 936.0), Adrenal (RPKM 211.8) and 6 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See As3mt in Genome Data Viewer
    Location:
    1q54
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255536879..255569245)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245595939..245628921)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266482787..266514570)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484084 Neighboring gene BLOC-1 related complex subunit 7 Neighboring gene uncharacterized LOC134484081 Neighboring gene uncharacterized LOC134484091 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Glutathione modulates recombinant rat arsenic (+3 oxidation state) methyltransferase-catalyzed formation of trimethylarsine oxide and trimethylarsine. Waters SB, et al. Chem Res Toxicol, 2004 Dec. PMID 15606138
    2. Elucidating the pathway for arsenic methylation. Thomas DJ, et al. Toxicol Appl Pharmacol, 2004 Aug 1. PMID 15276411
    3. A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol. Lin S, et al. J Biol Chem, 2002 Mar 29. PMID 11790780
    4. Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype. Li J, et al. Toxicol Appl Pharmacol, 2005 Apr 15. PMID 15808521
    5. Interactive Effects of N6AMT1 and As3MT in Arsenic Biomethylation. Zhang H, et al. Toxicol Sci, 2015 Aug. PMID 25997655, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In rat AS3MT, Cys156 located in a well-defined cavity structure may be situated to participate in the binding of substrates which contain A(III).
      Title: Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype.
    2. Enzyme catalyzing the conversion of inorganic arsenic to volatile arsenicals.
      Title: Glutathione modulates recombinant rat arsenic (+3 oxidation state) methyltransferase-catalyzed formation of trimethylarsine oxide and trimethylarsine.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables arsenite methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arsenite methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arsenite methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arsenite methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein methyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arsonoacetate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arsonoacetate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in arsonoacetate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arsonoacetate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to arsenic-containing substance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in toxin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in toxin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in toxin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in toxin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    arsenite methyltransferase
    Names
    S-adenosyl-L-methionine:arsenic(III) methyltransferase
    S-adenosylmethionine:arsenic (III) methyltransferase
    arsenic (+3 oxidation state) methyltransferase
    methylarsonite methyltransferase
    methyltransferase Cyt19
    NP_543166.2
    XP_038938593.2
    XP_038938624.1
    XP_063127220.1
    XP_063127291.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080890.2 → NP_543166.2  arsenite methyltransferase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q8VHT6
      UniProtKB/TrEMBL
      A6JHN7, G3V8P2
      Related
      ENSRNOP00000027223.5, ENSRNOT00000027223.8
      Conserved Domains (1) summary
      PRK11873
      Location:60 → 265
      arsM; arsenite methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      255536879..255569245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082696.2 → XP_038938624.1  arsenite methyltransferase isoform X3

      UniProtKB/Swiss-Prot
      Q8VHT6
      Conserved Domains (1) summary
      PRK11873
      Location:60 → 206
      arsM; arsenite methyltransferase

    2. XM_063271150.1 → XP_063127220.1  arsenite methyltransferase isoform X2

    3. XM_039082665.2 → XP_038938593.2  arsenite methyltransferase isoform X1

    4. XM_063271221.1 → XP_063127291.1  arsenite methyltransferase isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHT6.1 GenPept UniProtKB/Swiss-Prot:Q8VHT6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous