Ptpro protein tyrosine phosphatase, receptor type, O [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptproprovided by RGD
Official Full Name: protein tyrosine phosphatase, receptor type, Oprovided by RGD
Primary source: RGD:62068
See related: EnsemblRapid:ENSRNOG00000006231 AllianceGenome:RGD:62068
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GLEPP1; RPTP-BK
Summary: Enables protein tyrosine phosphatase activity. Involved in negative regulation of glomerular filtration. Predicted to be located in apical plasma membrane; dendritic spine; and lateral plasma membrane. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 130.6), Brain (RPKM 85.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q43-q44

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (171895104..172105911)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (170164071..170374790)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (171250766..171461571)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTPRO inhibition ameliorates spinal cord injury through shifting microglial M1/M2 polarization via the NF-kappaB/STAT6 signaling pathway.
Title: PTPRO inhibition ameliorates spinal cord injury through shifting microglial M1/M2 polarization via the NF-κB/STAT6 signaling pathway.
PTPRO knockdown protects against inflammation in hemorrhage shock-induced lung injury involving the NF-kappaB signaling pathway.
Title: PTPRO knockdown protects against inflammation in hemorrhage shock-induced lung injury involving the NF-κB signaling pathway.
PTPro interaction with specific antibodies acutely increases albumin permeability in glomerular podocytes.
Title: Antibodies to protein tyrosine phosphatase receptor type O (PTPro) increase glomerular albumin permeability (P(alb)).
Upregulation of B7.1 with the downregulation of GLEPP1, Wilms' tumor gene (WT1), megalin, and vascular endothelial growth factor started early and persisted through the course of primary glomerular disease
Title: Early changes in gene expression that influence the course of primary glomerular disease.
Results suggest that GLEPP1 (Ptrpo) expression reflects podocyte injury induced by puromycin aminonucleoside.
Title: GLEPP1 receptor tyrosine phosphatase (Ptpro) in rat PAN nephrosis. A marker of acute podocyte injury.

Submit: New GeneRIF Correction

General gene information

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Markers

Ptpro (e-PCR), detects polymorphism
- UniSTS:186529

RH141958 (e-PCR)
- UniSTS:223949

RH127867 (e-PCR)
- UniSTS:211177

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info
enables Wnt-protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in glomerulus development	ISO Inferred from Sequence Orthology more info
involved_in glomerulus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in monocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	NAS Non-traceable Author Statement more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in podocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in podocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in podocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glomerular filtration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in regulation of glomerular filtration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in slit diaphragm assembly	ISO Inferred from Sequence Orthology more info
involved_in slit diaphragm assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase O

Names: Glomerular epithelial protein 1; receptor-type protein tyrosine phosphatase D30

NP_059032.1

EC 3.1.3.48

XP_006237633.1

EC 3.1.3.48

XP_017448340.1

EC 3.1.3.48

XP_038964206.1

EC 3.1.3.48

XP_038964207.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017336.2 → NP_059032.1 receptor-type tyrosine-protein phosphatase O precursor

See identical proteins and their annotated locations for NP_059032.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I6AS38, F7F9Z5, Q62797

Related

ENSRNOP00000044055.3, ENSRNOT00000040576.5

Conserved Domains (4) summary

smart00194
Location:937 → 1192

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:965 → 1193

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:434 → 526

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:725 → 805

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

171895104..172105911

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017592851.3 → XP_017448340.1 receptor-type tyrosine-protein phosphatase O isoform X1

UniProtKB/TrEMBL

A0A8I5YC57, F7F9Z5

Related

ENSRNOP00000077071.1, ENSRNOT00000097203.2
XM_039108278.2 → XP_038964206.1 receptor-type tyrosine-protein phosphatase O isoform X2

Conserved Domains (2) summary

cd00063
Location:434 → 526

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:725 → 805

fn3; Fibronectin type III domain
XM_039108279.2 → XP_038964207.1 receptor-type tyrosine-protein phosphatase O isoform X3

UniProtKB/TrEMBL

A6IMK3

Conserved Domains (2) summary

cd00063
Location:434 → 526

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:725 → 805

fn3; Fibronectin type III domain
XM_006237571.5 → XP_006237633.1 receptor-type tyrosine-protein phosphatase O isoform X4

Conserved Domains (2) summary

smart00194
Location:126 → 381

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:154 → 382

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...