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    Aspa aspartoacylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79251, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Aspaprovided by RGD
    Official Full Name
    aspartoacylaseprovided by RGD
    Primary source
    RGD:621693
    See related
    EnsemblRapid:ENSRNOG00000019659 AllianceGenome:RGD:621693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables identical protein binding activity. Involved in central nervous system myelination and positive regulation of oligodendrocyte differentiation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Used to study Canavan disease and essential tremor. Human ortholog(s) of this gene implicated in Canavan disease. Orthologous to human ASPA (aspartoacylase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 460.7), Brain (RPKM 63.0) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aspa in Genome Data Viewer
    Location:
    10q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (58390204..58443790, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57891704..57945267, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59839693..59888244, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene sedoheptulokinase Neighboring gene transient receptor potential cation channel, subfamily V, member 1 Neighboring gene transient receptor potential cation channel, subfamily V, member 3 Neighboring gene spermatogenesis associated 22 Neighboring gene olfactory receptor family 1 subfamily E member 1 Neighboring gene olfactory receptor family 1 subfamily E member 1C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of aspartoacylase in tremor expression in rats. Nishitani A, et al. Exp Anim, 2016 Jul 29. PMID 27026062, Free PMC Article
    2. Developmental increase of aspartoacylase in oligodendrocytes parallels CNS myelination. Kirmani BF, et al. Brain Res Dev Brain Res, 2003 Jan 10. PMID 12524181
    3. Immunohistochemical localization of aspartoacylase in the rat central nervous system. Madhavarao CN, et al. J Comp Neurol, 2004 May 3. PMID 15065127
    4. Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease. McPhee SW, et al. Brain Res Mol Brain Res, 2005 Apr 27. PMID 15857674
    5. Extensive aspartoacylase expression in the rat central nervous system. Moffett JR, et al. Glia, 2011 Oct. PMID 21598311, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myelin lesion in the aspartoacylase (Aspa) knockout rat, an animal model for Canavan disease.
      Title: Myelin lesion in the aspartoacylase (Aspa) knockout rat, an animal model for Canavan disease.
    2. Interaction of N-acetyl-L-aspartate accumulation due to ASPA deficiency with an unstable neuronal membrane potential caused by HCN1 deficiency was involved in tremor development.
      Title: Involvement of aspartoacylase in tremor expression in rats.
    3. The decrease in N-acetylaspartate following severe traumatic brain injury was characterized by profound mitochondrial malfunctioning, dramatic repression of Nat8l gene and concomitant increase in the ASPA gene and protein levels.
      Title: The molecular mechanisms affecting N-acetylaspartate homeostasis following experimental graded traumatic brain injury.
    4. This study demonistrated that aspartoacylase expression in the rat white matter central nervous system.
      Title: Extensive aspartoacylase expression in the rat central nervous system.
    5. The develomental increase of this enzyme in oligodendrocytes parallels CNS myelination.
      Title: Developmental increase of aspartoacylase in oligodendrocytes parallels CNS myelination.
    6. the N-terminal domain of aspartoacylase adopts a protein fold similar to that of zinc-dependent hydrolases related to carboxypeptidases A
      Title: Structure of aspartoacylase, the brain enzyme impaired in Canavan disease.
    7. ASPA colocalized throughout the brain with CC1, a marker for oligodendrocytes, with 92-98% of CC1-positive cells also reactive with the ASPA antibody.
      Title: Immunohistochemical localization of aspartoacylase in the rat central nervous system.
    8. describe the occurrence of ASPA within nuclei of rat brain and kidney, and in cultured rodent oligodendrocytes.
      Title: Aspartoacylase is a regulated nuclear-cytoplasmic enzyme.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93407, MGC93408

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aspartoacylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aspartoacylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables aspartoacylase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aspartate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system myelination IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aspartoacylase
    Names
    ACY-2
    aminoacylase-2
    NP_077375.2
    XP_006246880.1
    XP_017453032.1
    XP_038942843.1
    XP_038942844.1
    XP_038942846.1
    XP_038942847.1
    XP_063125987.1
    XP_063125988.1
    XP_063125989.1
    XP_063125990.1
    XP_063125991.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024399.2 → NP_077375.2  aspartoacylase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q6AZ03, Q9R1T5
      UniProtKB/TrEMBL
      A0A8L2RC31, A6HGJ6
      Conserved Domains (1) summary
      cl11393
      Location:10 → 299
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      58390204..58443790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269919.1 → XP_063125989.1  aspartoacylase isoform X4

      UniProtKB/TrEMBL
      A0A1W2Q5Z4, A6HGJ4
      Related
      ENSRNOP00000076074.3, ENSRNOT00000093579.3

    2. XM_063269918.1 → XP_063125988.1  aspartoacylase isoform X4

      UniProtKB/TrEMBL
      A0A1W2Q5Z4, A6HGJ4

    3. XM_039086919.2 → XP_038942847.1  aspartoacylase isoform X6

      UniProtKB/TrEMBL
      A0A8I6ATJ0
      Conserved Domains (1) summary
      cd06909
      Location:11 → 192
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

    4. XM_063269921.1 → XP_063125991.1  aspartoacylase isoform X7

    5. XM_006246818.5 → XP_006246880.1  aspartoacylase isoform X3

      UniProtKB/TrEMBL
      A0A1W2Q6K0, A0A8I6ATJ0
      Conserved Domains (2) summary
      cd06909
      Location:11 → 248
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
      pfam04952
      Location:9 → 247
      AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family

    6. XM_039086915.2 → XP_038942843.1  aspartoacylase isoform X1

      UniProtKB/Swiss-Prot
      Q6AZ03, Q9R1T5
      UniProtKB/TrEMBL
      A0A8L2RC31, A6HGJ6
      Related
      ENSRNOP00000072876.2, ENSRNOT00000084432.4
      Conserved Domains (1) summary
      cl11393
      Location:10 → 299
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    7. XM_063269917.1 → XP_063125987.1  aspartoacylase isoform X2

    8. XM_039086916.2 → XP_038942844.1  aspartoacylase isoform X1

      UniProtKB/Swiss-Prot
      Q6AZ03, Q9R1T5
      UniProtKB/TrEMBL
      A0A8L2RC31, A6HGJ6
      Conserved Domains (1) summary
      cl11393
      Location:10 → 299
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    9. XM_017597543.3 → XP_017453032.1  aspartoacylase isoform X2

      UniProtKB/TrEMBL
      A0A8L2RC31

    10. XM_063269920.1 → XP_063125990.1  aspartoacylase isoform X5

      UniProtKB/TrEMBL
      A0A0H2UHY8
      Related
      ENSRNOP00000050760.5, ENSRNOT00000049311.6

    11. XM_039086918.2 → XP_038942846.1  aspartoacylase isoform X5

      UniProtKB/TrEMBL
      A0A0H2UHY8, A0A8I6ATJ0
      Conserved Domains (1) summary
      cd06909
      Location:11 → 205
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

    RNA

    1. XR_010055268.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1T5.2 GenPept UniProtKB/Swiss-Prot:Q9R1T5

    Gene LinkOut

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